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Generic name: canagliflozin [KAN-a-gli-FLOE-zin]
The brand name is Invokana.
Dosage format: oral tablet (100 mg, 300 mg)
Drug class: SGLT-2 inhibitors

What is Canagliflozin?

Canagliflozin can be used in conjunction with exercise and diet in order to help improve the control of blood sugar levels in people suffering from type 2 diabetes mellitus.

Canagliflozin is also used in order to decrease the risk of death due to stroke, heart attack, or heart failure in people with type 2 diabetes and heart disease.

Canagliflozin can be utilized in order to lower the risk of end-stage kidney disease and the death or hospitalization caused by heart disease in people who have kidney disease due to diabetes type 2. diabetics..Canagliflozin is not a treatment for type 1 diabetes.Canagliflozin can also be utilized for other purposes that aren't listed in this guideline.

Side effects of Canagliflozin

See a doctor immediately. Get medical attention immediately if you notice indications that indicate an allergic reaction, such as difficulty breathing, hives, or swelling of your lips, face, tongue, or throat.

Get medical attention promptly if you are experiencing symptoms of a genital illness (penis or vagina): burning, itching, or stinging; smell of bleeding; pain or discharge; redness; tenderness or swelling of the rectal or genital region; fever; or having trouble sleeping. The symptoms could worsen rapidly.

Canagliflozin may cause serious side effects. Contact your physician immediately if you experience:

  • A feeling of lightheadedness, as if it's possible to pass out.
  • Very little or none;
  • Burning or pain during urination;
  • New pain, tenderness, ulcers, sores, or infections that affect the feet or your legs;
  • Excessive potassium, high potassium, nausea, and irregular heartbeats. weakening, slowing down;
  • Ketoacidosis (too much acid present in the blood): nausea, vomiting, stomach pain, agitation, strange tiredness, or difficulty breathing, as well as
  • ehydration symptoms include weakness, dizziness, and a sensation of lightheadedness (like you're about to faint).

There is a higher chance of suffering a fractured bone when you take canagliflozin. Discuss with your physician what you can do to minimize the possibility of developing fractures.

Some side effects could be more common when older people are present.

The most common side effects from canagliflozin could be:

  • Genital infections
  • Urinating more frequently than normal

This isn't an exhaustive listing of all side effects. There are other possible side effects. Consult your physician for advice regarding medical adverse consequences. It is possible to report any side effects to the FDA by calling 1-800-FDA-1088.


It is not recommended to take canagliflozin when you suffer from an extreme kidney condition or are on dialysis.

Canagliflozin may cause severe infections of the penis or vagina. Get medical help immediately if you notice irritation, burning, odor, or discharge, as well as pain, redness, tenderness, or swelling in the rectal or genital region, or if you're not feeling well.

Before you Take this Drug

It is not recommended to take canagliflozin if you have an allergy to it or are suffering from

  • Chronic kidney illness (or those who are taking dialysis).

Canagliflozin can increase the risk of lower leg amputations, particularly if you've previously had an amputation, a leg ulcer, a heart condition, circulatory problems, or an injury to your nerve.

Inform your physician if you experienced:

  • Heart problems
  • A diabetic foot ulcer or amputation
  • Issues with circulation or nerves within your feet or legs;
  • Kidney disease
  • Liver disease;
  • Urinary tract infections and other issues;
  • A pancreas disorder;
  • If you are a frequent drinker or consume large quantities of alcohol,
  • If you're taking fewer calories than normal and you are not feeling well,
  • If you're on a diet low in salt.

Take your medical professional's advice on taking canagliflozin if you're expecting. Blood sugar control is vital when you are pregnant, and your dosage requirements may differ throughout every trimester.Do not take canagliflozin in your 2nd or 3rd trimester of pregnancy.It is not recommended to breastfeed when you are taking this medication.Canagliflozin is not a drug that has been approved for use by people less than 18 years of age.

How to Take Canagliflozin?

Be sure to follow the directions printed on your prescription label. You should also go through all the drug guides and instructions. The doctor might change the dosage. Follow the medication exactly as prescribed.

Canagliflozin is typically taken once each day, prior to breakfast, which is the most important meal of the day.There is a possibility that you will have high blood pressure during the course of this medication. Contact your physician if you feel sick, have vomiting or diarrhea, or find yourself sweating more than normal. Take plenty of fluids when you take canagliflozin.

There is a possibility that you are suffering from lower levels of blood sugar (hypoglycemia) and experiencing extreme hunger or dizziness. It can also make you feel angry and anxious. You may also feel confused, anxious, or even shaky. For quick treatment of hypoglycemia, consume or drink a rapid-acting food source that contains sugar (fruit juice crackers, hard candy raisins, or any other non-diet drinks).

The doctor might prescribe a glucose injection kit in the event that there is extreme hypoglycemia. Make sure that your family members or friends are aware of what to do with the injection in case of a crisis.Additionally, look out for indications of excessive glucose levels (hyperglycemia), like an increase in thirst or increased urination.

The levels of blood sugar may be impacted due to illness, stress, surgery, exercising, alcohol consumption, or avoiding meals. Consult your physician prior to making changes to your medication or dosage plan.

Canagliflozin is a small part of a full treatment regimen that may include exercises, diet, and weight management, as well as blood sugar tests and medical attention that is specific to you. Always follow the instructions of your doctor carefully.This medication can alter the outcome of certain tests. Inform any physician who is treating patients that you're taking canagliflozin.Place it in a cool, dry place free of heat and moisture.

What Happens If I Miss a Dose?

Do not take the medication as fast as you are able, but avoid the dose you missed in the event that it's time for the next dose. Don't take more than two doses simultaneously.

What Happens If I Overdose?

For medical emergencies, seek emergency treatment or dial for help at the Poison Help line at 1-800-222-1222.

What Should be Avoided?

Do not get up too quickly from a lying position, as you could be dizzy.

Interaction with Other Drugs

Inform your physician about any other medications you take, including:

  • Insulin and other diabetes oral medications;
  • A diuretic "water pill";
  • Digoxin, digitalis;
  • Rifampin;
  • Ritonavir
  • Seizure medication (phenobarbital, phenytoin).

The list below isn't complete. Certain other drugs can affect canagliflozin as well, such as medicine that is prescribed or over-the-counter, vitamins, and natural products. There are many possible interactions between drugs that are included here.