What is Diprivan?
Diprivan reduces activity in your nervous system and brain. Diprivan helps you relax and prepare for surgery or any other medical procedure that requires general anesthesia. Diprivan can also be used to sedate patients who are in critical care and need a breathing machine (mechanical ventilator).
Warnings
Tell your doctor all of your allergies and medical conditions before you start taking Diprivan. Tell your doctor if you're pregnant or breastfeeding. Diprivan may not be available in some situations.
Before you take this drug
If you have an allergy to propofol, then diprivan should be avoided.
Tell your doctor about any of the following to ensure that Diprivan will be safe for you:
- Epilepsy or another seizure disorder
- High cholesterol or triglycerides in the blood (a type of fat).
Anesthesia medicines can affect the brain development of a child younger than 3 years old, or if the mother takes them during pregnancy. The effects are more likely to occur if the anesthesia treatment is prolonged or repeated. The effects on brain development can cause problems with learning and behavior later in life. In animal studies, anesthesia has been shown to have negative effects on the brain. Studies on human children who received a single, short anesthetic did not show any effect on learning or behavior. Further research is required. In some cases, your doctor may decide to delay a procedure or surgery based on the risks. In the event of a life-threatening condition, a medical emergency, or if surgery is needed to correct faulty birth defects, treatment cannot be delayed. You should also ask your doctor about the medicines that are going to be used in your surgery. Ask how long the surgery or procedure will take. Propofol may pass into breastmilk and harm a nursing infant. This medicine should not be taken while breastfeeding.
Similar/related drugs
Fentanyl, lidocaine, ketamine, hyoscyamine, propofol, and glypyrrolate
What happens if I miss the dose?
Diprivan will be administered by a health care professional in a medical environment, so you won't miss a single dose.
What happens if I overdose?
Overdoses are unlikely because this medication is administered by a health professional in a medical environment.
What should be avoided?
Diprivan may cause dizziness or severe drowsiness that can last several hours. After your surgery or procedure, you will need someone else to drive home. You should not drive or do anything else that requires alertness for at least 24 hours after receiving Diprivan.
Side effects of Diprivan
If you experience any of the following symptoms of an allergic reaction: hives, difficulty breathing, swelling of your lips, face, tongue, or throat,
If you:
- A feeling of lightheadedness (like you could pass out), even though you feel awake.
- Weak or shallow breathing
- There may be some discomfort or pain where the injection was given.
Diprivan may cause side effects such as:
- Itching and rash that is mild
- Fast or slow heart rate
- There may be a slight burning sensation or stinging at the site of the IV needle.
There may be other side effects. For medical advice on side effects, call your doctor.Contacting the FDA directly in regards to adverse side effects is simple - call them on their hotline number of 1-800-FDA-1088!
Details on dosage
Usual Adult Dose for Anesthesia:
Anesthetic Induction for Less Than 55 Years Old: 40 mg IV, every 10 seconds, until induction begins. The total dose is between 2 and 2.5 mg/kg, with a maximum dosage of 250 mg.
Infusion of 100–200 mcg/kg/min for maintenance anesthesia in patients under 55 years Maximum dose: 20,000 mcg/min. Maximum dose: 10,000 mcg/min.
As needed, an intermittent bolus of 20–50 mg
Cardiac Anesthesia Induction: 20mg every 10 seconds (0.5–1.5 mg/kg) until the induction begins.
Maintenance: Diprivan and opioids are usually combined to maintain anesthesia.
Propofol (primary): 100-150 mcg/kg/min
Secondary propofol: 50-100 mcg/kg/min
The maximum dose is 15,000 mcg/min.
Neurosurgery: Induction 20 mg every 10 seconds until induction begins (1 to 2 mg/kg).
Maintenance: 100–200 mcg/kg/min, with a maximum of 20,000 mcg/min.
For maintenance of anesthesia, intermittent IV bolus dosages of 0.3–0.7 mg/kg may be administered.
ICU Sedation Initial Continuous IV: 5 mcg/kg/min in mechanically ventilated intubated patients
Maintenance Continuous IV: Increase in increments of 5 to 10 mg/kg/min every 5 minutes, until the desired level is reached. The typical maintenance range is between 5 and 50 mcg/kg/min.
The 10–20 mg bolus dose should be administered only to increase the depth of sedation quickly in patients who are unlikely to experience hypotension.
Initial continuous IV: 100–150 mcg/kg/min, for 3–5 min.
Slow IV: 0.5 mg/kg for 3 to 5 min, followed by:
Maintenance IV infusion: 25–75 mcg/kg/min, preferred.
Bolus doses are 10–20 mg increments.
The usual dose of anesthesia for geriatric patients:
Patients who are elderly, debilitated, or have ASA III or IV
Induction: 20mg every 10 seconds (1–1.5 mg/kg) until induction begins. Maximum dose: 200 mg
Maintenance: 50–100 mcg/kg/min.
MAC sedation is 80% of what an adult would normally take.
The usual pediatric dose of anesthesia:
3 years to 16 years: Induction: 2.5–3.5 mg/kg in 20–30 seconds
Maintenance: 125–300 mcg/kg/min.
Interaction with other drug
Other medicines that slow breathing or make you sleepy can exacerbate these effects. Ask your doctor if you should take a sleeping pill, narcotic pain medication, prescription cough medicine, or muscle relaxant after taking Diprivan. Propofol may interact with other drugs, such as prescription and over-the-counter medicines, herbal products, and vitamins. Inform your healthcare providers of all medications you are taking and those you plan to take.
