What is Dexmedetomidine (buccal/sublingual)?
Adults are treated with dexmedetomidine buccal or sublingually to reduce agitation that is associated with schizophrenia, or bipolar I and II disorders. After 24 hours of initial use, safety and efficacy have not been proven. Dexmedetomidine, buccal or sublingual, may be used in other ways not mentioned in the medication guide.
Side effects of Dexmedetomidine (buccal/sublingual)
If you experience difficulty breathing, hives, swelling in your lips, face, throat or tongue - any of which are indicators that your allergies could be present - an allergy test might help determine what's going on and bring relief.
Dexmedetomidine can cause severe side effects. If you experience:
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Heartbeats that are fast, irregular, or slow
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Feeling lightheaded as though they could pass out.
Dexmedetomidine can cause a number of side effects.
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Drowsiness;
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Dizziness;
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Numbness, tingling, burning pain;
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Dry mouth, loss of feeling in the mouth
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Feeling like you might pass out.
There may be other side effects. For medical advice on side effects, call your doctor.Report side effects by calling the FDA at 1-800-FDA-1088.
Similar/related drugs
Trazadone, Hydroxyzine, Lorazepam, Olanzapine, Promethazine, Ativan, and Fentanyl
Warnings
Do not use it other than as prescribed. Inform your doctor of any other medications you are taking or if there is a medical condition or allergy.
Before you take this drug
If you've ever:
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Liver disease
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Diabetes;
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High blood pressure
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Low blood pressure or dehydration
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A serious condition of the heart, such as severe heart block.
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A heart rhythm disorder.
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Long qt syndrome.
Dexmedetomidine is not proven to harm unborn babies.Informing your physician of any pregnancy or plans to conceive will keep them fully aware of all potential dangers to both parties involved and will enable you to get timely medical assistance if there are complications during gestation or delivery.Tell your doctor about irritability if the baby is nursing.
How to take Dexmedetomidine (buccal/sublingual)?
Read all the instructions or guides that come with your medication and follow the directions. Sometimes, your doctor will change the dose. You must take the medication exactly as prescribed. Dexmedetomidine should only be taken under supervision by a health professional. Dexmedetomidine can be placed under the lower lip or beneath the tongue. Do not swallow or chew the buccal or sublingual dexmedetomidine. After sublingual or buccal application, do not consume any food or liquids for 15 minutes. After using sublingual or buccal dexmedetomidine, remain seated or lie down. As part of treatment, your vital signs will be closely monitored. After discontinuing dexmedetomidine use, withdrawal symptoms may arise, with nausea, vomiting and agitation typically being among them. Keep the dexmedetomidine foil pouch away from heat and moisture.
Details on dosage
Adult dose for sedation:
Intensive Care Unit sedation
Initial Dose: Infuse 1 mg/kg over 10 minutes.
Maintenance Dose: Infusion of 0.2–0.7 mcg/kg/hour; the rate should be adjusted to produce the desired effect.
Procedure Session:
Initial Dose: Infuse 1 mg/kg over 10 minutes.
Maintenance Dose: Start the IV infusion with 0.6 mg/kg/hour, and then titrate the dose to reach the desired clinical effects. The range of dosages can be from 0.2 mg/kg/hour to 1 mg/kg/hour.
Usages: sedation for mechanically ventilated and intubated patients in intensive care; sedation before and/or after surgical procedures; and sedation for non-intubated patients.
The usual dose for sedation in geriatric patients is:
After 65 years of age:
Intensive Care Unit Sedation: A dose reduction is possible, but no guidelines are provided.
Procedure Session:
Initial Dose: Can be reduced or omitted (e.g., 0.5 mg/kg intravenous infusion for 10 minutes).
Maintenance Dose: A dose reduction is possible, but no guidelines are provided.
Usages: sedation for mechanically ventilated and intubated patients in intensive care; sedation before and/or after surgical procedures and other treatments.
What happens if I miss the dose?
If you forget to take a dosage, call your doctor.
What happens if I overdose?
Call 1-800-222-1222 for poison help or seek immediate medical attention.
What should be avoided?
Dexmedetomidine can cause you to feel dizzy or drowsy. Be wary of taking part in dangerous activities until you understand their effects on you and their impact on any accidents that might result from engaging. Drowsiness or dizziness could result in accidents and severe injuries.
Interaction with other drug
Dexmedetomidine can lead to serious heart problems. You may also be at greater risk if you are taking other medications for asthma, HIV, mental illnesses, HIV, malaria, or HIV. Before taking an opioid, sleeping pills, muscle relaxers, or medicines for anxiety or seizures, ask your doctor. Dexmedetomidine may interact with other drugs, including prescription, over-the-counter, and herbal medicines. Inform your doctor of all the other medications you take.
