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Brand names include:  Ambifed-G and Entex T. Other brands include Mucinex, Mucinex Max Strength, Mucinex, Mucinex-D, and Maxifed.
Class of drugs: Combinations for upper respiratory tracts

What is Despec-SR?

Despec-SR, an antihistamine combination, is used to treat symptoms of allergies in both adults and children, including runny and stuffy noses, itchy eyes and noses, mucusy coughs, and sinus pain. It also reduces chest congestion due to the cold or other allergies. This leaflet does not list all the brands of pseudoephedrine or guaifenesin. Despec-SR can also be used in other ways not mentioned in the medication guide.

Side effects of Despec-SR

If you experience any of the following symptoms of an allergy reaction, seek immediate medical attention: difficulty breathing or swelling in your lips, face, throat, or tongue. Despec-SR can cause severe side effects. Despec-SR should be stopped immediately, and you must call your doctor if:

  • Nervousness, dizziness, and sleep problems (insomnia).

There may be other side effects.Call your doctor immediately if experiencing side effects; to report side effects call the FDA directly at 1-800-FDA-1088.


Despec-SR should not be used if an MAO inhibitor has been taken in the last 14 days. There could be a dangerous drug interaction. The MAO inhibitors are isocarboxazid (linezolid), phenelzine, and tranylcypromine. Taking Despec-SR in excess of the recommended dosage will not increase its effectiveness and can cause severe side effects.

Before you take this drug

Despec-SR should not be used if MAO inhibitors have been taken in the last 14 days. It is possible that a dangerous drug interaction will occur. There are several MAO inhibitors, including isocarboxazid and linezolid.

If you or a family member have:

  • Heart disease
  • High blood pressure
  • Diabetes;
  • A thyroid condition;
  • Prostatic hypertrophy can cause urination issues.
  • Chronic coughs are caused by asthma, smoking, or another breathing disorder.

Informing your physician of any pregnancy or breastfeeding will allow for faster diagnosis. This medicine should not be given to children without consulting a doctor.

How to take Despec-SR?

Follow the instructions on the packaging or those prescribed by your physician. Cold and cough medicines are only to be used for a short time. Despec-SR should be administered to a young child according to the instructions. Never use this medication to put a young child to sleep. If you take more of this medication than recommended, it will not be as effective and can cause side effects. Use the measuring tool provided to measure liquid medicines (not your kitchen spoon). Do not chew or crush the Extended Release Tablet. Drink a glass of full water when taking the tablet. If you change the brand, strength, or form of a medicine, your dose requirements may be different. Use the medication exactly as instructed on the package or prescribed by your physician to avoid any mistakes.

If your symptoms don't improve after seven days or worsen, call your doctor. Also, you should contact your physician if there is a fever, rash, or headache. Keep away from heat and moisture. Store at room temperature.

What happens if I miss the dose?

Despec SR can be used as needed. You should not take any doses if you have a regular schedule. Never use more than one dose at a time.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

Before taking any other cold or cough medicines, ask your doctor or pharmacist if they contain the same ingredients.

Interaction with other drug

Before taking any other medications that may cause sleepiness, such as opioids, muscle relaxers, sleeping pills, anxiety medicines, or seizure medicine, consult your doctor or pharmacist. Inform your doctor of all the medicines that you take. Included are prescription, over-the-counter, vitamin, and herbal products. This list does not include all interactions.