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Generic name: l-methylfolate [L-METH-il-FOE-late]
The brand names are: Denovo, Deplin, Elfolate L-Methylfolate Forte, XaQuil XR, and L-Methylfolate Formula.
Drug class: vitamins

What is Denovo?

Folate is a type of B vitamin that is found naturally in a variety of foods. Folic acid is a man-made version of folate that is added to food items or supplements to increase mineral and vitamin intake. Folate is required by the human body to aid in the production of red blood cells.

A deficiency in folate within the human body could be caused by certain illnesses, medications, or simply insufficient folate in your diet. Folate deficiency may cause reduced red blood cells as well as anemia. Folate deficiency can also cause high levels of a certain amino acid in the blood, a condition called hyperhomocysteinemia (HYE-per-HOE-moe-sis-tin-EE-mee-a).

Denovo can be described as an agro-nutrient that can be used in patients suffering from ailments that are related to folate deficiency. The medicine is also used for people suffering from major depression with folate deficiency or those suffering from schizophrenia who suffer from hyperhomocysteinemia that is related to folate deficiency. Denovo does not function as an antidepressant or antipsychotic medication. However, it could increase the effectiveness of antidepressant medication. Denovo could also be used to treat conditions that are not mentioned in this guideline for medication.

Side effects of Denovo

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergy, such as symptoms of hives, breathing difficulties, or swelling of your lips, face, and tongue, The less severe side effects might be experienced, and you could not experience any at all.

This isn't an exhaustive list of all side effects. Other side effects could occur. Contact your physician to seek medical advice on the effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Similar or related drugs

Folic acid, Deplin, l-methylfolate, Folacin-800, and Elfolate


Follow the directions on the label of your medication and on the label of your package. Inform your health care providers about your allergies, medical conditions, and any other medications you take.

Before taking this medication

You shouldn't take Denovo if you are allergic to it.

To ensure that Denovo is appropriate for you, consult your doctor if you suffer from:

  • Seizures or epilepsy;
  • An underlying past history of an underlying vitamin b12 deficiency (or the pernicious form of anemia or
  • A past that suggests an underlying bipolar disorder (manic depression)

Speak to your physician if you are nursing or pregnant. The dosage requirements for you could differ in the course of pregnancy or when you are breastfeeding.

How to take Denovo?

Follow the instructions on the prescription label. Don't consume Denovo in smaller or larger quantities or for longer than prescribed. Only use the amount of L-methylfolate the doctor prescribed. Don't change brands without consulting your doctor.

You can consume Denovo either with or without meals. Follow your doctor's prescriptions. Do not chew, crush, or break an extended-release tablet. Suck it up whole. Don't give this medication to another person, even if they suffer from similar symptoms to yours.

Denovo is only a small part of a comprehensive program of treatment, which may also include other medicines and psychological counseling for people suffering from depressive disorders and schizophrenia. Be sure to follow your treatment and counseling regimen extremely closely.

Do I be concerned if I miss a dose?

Do the dose you missed as quickly as you remember. Avoid your missed dosage if it's nearing the time for your next dose. Don't take any extra medication to make up for the missed dose.

What will happen if I take excessively?

A dose too high of Denovo is unlikely to cause any life-threatening effects.

What should be avoided?

Follow the instructions of your physician regarding any restrictions on your food, drink, or any activity.

Interaction with other drugs

Discuss with your physician your current medications as well as those you are about to stop or start taking, including:

  • Capecitabine;
  • Fluoxetine (prozac);
  • Isotretinoin;
  • Methotrexate;
  • Methylprednisolone;
  • Pancrelipase;
  • Pyrimethamine;
  • Triamterene;
  • Trimethoprim;
  • Warfarin (coumadin, jantoven);
  • Birth control pills;
  • Oral diabetes medicine that has metformin (glucophage, avandamet, metaglip, and more);
  • These are nsaids (nonsteroidal anti-inflammatory drugs): aspirin, ibuprofen, aspirin (advil, motrin), naproxen (aleve), as well as celecoxib, diclofenac (also known as indomethacin), diclofe, and others.
  • Seizure medicine: carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, and valproic acid.

This list isn't complete. Other medications can interact with l-methylfolate. This includes prescription and over-the-counter medicines, vitamins, and herbal products. The interactions of all potential drugs are included in this guideline for medication.