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Chlophedianol (phenylephrine) and pyrilamine

Brand Name: Pro-Chlo
Dosage form: oral liquid (12.5 mg–5 mg–5 ml)
Drug Class: Upper Respiratory Combinations

What is chlophedianol, phenylephrine, and pyrilamine?

Chlophedianol suppresses coughing. It works by affecting the signals that are sent to the brain and triggering the cough reflex.Phenylephrine shrinks the blood vessels of the nasal passages. Nasal congestion may be caused by dilapidated blood vessels.Pyrilamine, an antihistamine, reduces the effects that histamine has on the body. Histamine can cause symptoms such as sneezing and itching. It may also cause watery eyes and a runny or stuffy nose.Combination medicine containing phenylephrine and pyrilamine to treat allergies, flu, common cold, or runny nose.Chlophedianol, phenylephrine, and pyrilamine do not treat coughs caused by asthma, bronchitis, or emphysema.This medication guide does not list all possible uses for pyrilamine, phenylephrine, and chlophedianol.

Side effects of Chlophedianol (phenylephrine) and pyrilamine

If you experience symptoms indicative of an allergic reaction, such as hives, difficulty breathing or swelling of lips, face, tongue or throat - seek medical assistance immediately!

This medicine can cause serious side effects. If you experience:

  • Shortness of breath.
  • Severe drowsiness;
  • A feeling of lightheadedness, as if you could pass out.
  • Little or no urinating is acceptable.
  • Severe dizziness or anxiety;
  • Severe restlessness or inability to sleep.

Chlophedianol and phenylephrine may cause side effects such as:

  • Mild dizziness, drowsiness, or mild vertigo
  • Dry mouth, nose, or throat
  • Diarrhoea, constipation, upset stomach;
  • Feeling restless or excited, especially in children
  • Blurred vision
  • Sleep problems (insomnia).

There may be other side effects. Call your physician immediately if experiencing side effects; for reporting purposes contact 1-800-FDA-1088 to file reports of side effects.


If you've taken an MAO inhibitor within the last 14 days, do not take chlophedianol or phenylephrine. Harmful drug interactions may occur. MAO inhibitors are isocarboxazid linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, transylcypromine, and others.

Before you take this drug

If you've used an MAO inhibitor in the last 14 days, do not take this medication. It is possible that a dangerous drug interaction will occur. MAO inhibitors are isocarboxazid (linezolid), phenelzine (phenelzine injection), rasagiline (selegiline), tranylcypromine, and other drugs.This medicine should not be used if you have an allergy to phenylephrine or pyrilamine.If you have any other medical conditions or concerns, ask your doctor or pharmacist whether it's safe to take the medicine.

  • Any type of breathing disorder
  • Blockage of your intestines
  • Other urination issues or bladder obstruction
  • Cough with mucus
  • Glaucoma;
  • Diabetes;
  • Liver or kidney disease
  • Heart disease, high blood pressure
  • A thyroid disorder,
  • If you are taking potassium (Cytra Epiklor K-Lyte K-Phos Kaon Klor-Con Polycitra Urocit-K),

FDA pregnancy class C There is no information on whether chlophedianol, phenylephrine, or pyrilamine can harm a developing baby. If you are pregnant, do not take this medication without consulting your doctor.Chlophedianol and phenylephrine can pass through breast milk, which may be harmful to a nursing infant. Decongestants and antihistamines can also reduce breast milk production. If you are breastfeeding a child, do not take this medication without consulting your doctor.

How to take Chlophedianol (phenylephrine) and pyrilamine?

Do not exceed the recommended dosage or duration. Use the recommended dose or duration. Do not exceed it. Cold or cough medicine typically only need be taken for a limited amount of time until symptoms have subsided, before stopping use entirely.This medication should not be given to children younger than four years of age. Ask a doctor first before giving cough or cold medication to your child. Children as young as 4 years old can die from the misuse of cough and cold medicines.Use a medicine cup or spoon to measure liquid medicines. Consult with your pharmacist if you do not possess an instrument capable of accurately measuring doses.If your symptoms don't improve within 7 days or you experience a fever, headache, cough, or skin rash, call your doctor.Tell your doctor or surgeon if you've taken cough medicine or cold medication in the last few days.Store away from moisture or heat at room temperature. Store at room temperature, away from moisture and heat.

Details on dosage

Adult dose for nasal congestion and cough:

Chlophedianol/phenylephrine/pyrilamine 12.5 mg-5 mg-12.5 mg/5 ml oral liquid:
Do not exceed 40 ml per day.The usual paediatric dose for nasal congestion and cough:Chlophedianol/phenylephrine/pyrilamine 12.5 mg-5 mg-12.5 mg/5 ml oral liquid:
From 6 to 11 years old: 5 ml every 6 hours orally, not to exceed 20 ml/day.
10 ml every 6 hours orally, not exceeding 40 ml/day.

What happens if I miss the dose?

You may not have a schedule for taking cough and cold medicines. If you have a regular schedule, take the missed dose immediately after you remember. If your next scheduled dosage is approaching, skip the missed dose. You should not take extra medicine to compensate for a missed dose.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

Chlophedianol can cause blurred vision or affect your ability to think or react. If you are driving or doing anything else that requires alertness and the ability to see clearly, be careful.Before using any other cold or allergy medicine, cough, or sleep medication, consult your doctor or pharmacist. Many combination medicines contain antihistamines, antitussives, and decongestants. Combining certain products can lead to an overdose of certain drugs. You can check the label of a medication to see if it contains antihistamines, antitussives, or decongestants.Alcohol can enhance the side effects caused by chlophedianol.

Interaction with other drug

Before using this medication, ask your doctor or pharmacist if you also use any other medications, such as prescription and over-the-counter medicines, vitamins, and herbal products. When used together, some medicines can have unwanted or harmful effects. This medication guide does not list all possible interactions.This medicine can have adverse effects if taken with drugs that cause you to sleep or slow down your breathing. You should consult your doctor before combining chlophedianol with other drugs that make you sleepy or slow down breathing.