The Web Health



Generic Name: bupropion [byoo-PRO’pee-on byoo-PRO-pee-on]
Names of brands: Aplenzin, Forfivo XL, Wellbutrin SR, Wellbutrin XL, Zyban, and Budeprion XL
Classes of drugs: Miscellaneous antidepressants, Smoking cessation agents

What is Bupropion?

Bupropion is an FDA-approved antidepressant that was approved by the FDA in 1985. It treats depression and seasonal affective disorder and supports smoking cessation. This medication helps improve mood and reduces the desire for nicotine. It can be used to treat both addiction and mental health problems.Bupropion is thought to work by changing the way of levels of specific chemicals that are present in the brain.The Zyban Bupropion brand can be used to stop smoking. Other bupropion brands could be used to treat major depressive disorder and seasonal affective disorder.


It is not recommended to take bupropion in the event of seizures or a disorder of eating, or if you have recently stopped drinking medications for seizures, alcohol, or sedatives. If you are taking Wellbutrin for depression, you should not take Zyban to stop smoking.Do not take bupropion for 14 days prior to or 14 days after having taken an MAO inhibitors include isocarboxazid, rasagiline, linezolid, phenelzine, selegiline, and tranylcypromine. You shouldn't take this medicine for more than one disease at a time.Many young people are prone to thoughts of suicide after first starting an antidepressant. Keep an eye on any changes in your mood or signs. Notify your doctor if any of your symptoms worsen or become more severe.

Bupropion may trigger seizures, particularly in those with specific medical conditions or who are taking certain medications. Inform your doctor about your medical conditions and the medications you take.If you notice any new or more severe symptoms, tell your physician, for example, changes in your behavior, mood, panic attacks, anxiety, or trouble sleeping. Also, when you are feeling uncontrollably angry, irritable, or aggressive, anxious, hyperactive (mentally as well as physically), depressed, or contemplating suicide or harming yourself.

Before you Take this Drug

Do not take bupropion if you have taken an MAO inhibitor within the past 14 days. A potentially dangerous interaction between drugs could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, rasagiline, phenelzine, tranylcypromine, and many others.

Bupropion should not be taken if you are allergic to it or have previously had:

  • A seizure disorder
  • Eating disorder, like anorexia or bulimia.
  • If you recently stopped using alcohol, seizure medications, or a medication that is sedative (such as Xanax, Valium, Fiorinal, Klonopin, and others).

Do not take an MAO inhibitor for 14 days prior to or 14 days after taking bupropion. A dangerous drug interaction may occur. MAO inhibitors are isocarboxazid, rasagiline, linezolid, phenelzine, selegiline, tranylcypromine, and do not use this medication for more than one disease at a time. If you are taking bupropion to treat depression, do not take it with a plan to stop smoking. Bupropion can trigger seizures, in particular if you suffer from certain medical conditions or take certain medications. Discuss with your doctor the medical conditions you suffer from and the medications you take.

To ensure that this medication is appropriate for you, tell your doctor if you have any of the following:

  • A head injury, seizures, a head injury, or spinal cord tumors
  • Narrow-angle glaucoma
  • Heart disease, high blood pressure, or heart attack
  • Diabetes
  • Liver or kidney disease (especially cirrhosis)
  • Depression, bipolar disorder, or any other mental illness
  • If you drink alcohol.

Some young people who take an antidepressant might think about killing themselves. Your doctor should monitor your progress on a regular basis during appointments while you are taking this medication. Family members or other caregivers should be on the lookout for fluctuations in mood and symptoms. Talk to your doctor about this medication if you are expecting. It is not yet known if bupropion could affect a newborn baby. It is possible that you will experience the possibility of relapses in depression if you quit using your antidepressant. Inform your doctor immediately if you find yourself pregnant. Don't begin or stop taking bupropion without your doctor's guidance. If you're pregnant and you are a registered mother, your name could be added to the pregnancy registry to monitor what effects bupropion has on the baby. It might not be safe to breastfeed while taking this medication. Consult your physician about any potential risks.Bupropion is not a prescription drug for use by anyone less than 18 years old.

How to Take Bupropion?

Use bupropion as directed by your physician. Follow all the instructions on the prescription label. Do not take this medication in greater or lesser quantities or for a longer time than the recommended time. In excess of this medication, it could increase the risk of having a seizure. Don't crush, chew, or break an extended-release tablet. Suck the tablet completely. It is best not to change the dosage or stop taking bupropion at once in the event of seizures while taking this medication. The abrupt stoppage of bupropion can trigger unpleasant withdrawal symptoms.If you are taking Zyban to help you quit smoking, you will be able to smoke for about a week following the start of the medication. You should set a date for quitting smoking in your second week following treatment. Consult your physician if you're having difficulty quitting smoking after using Zyban for 7–12 weeks.

The doctor could prescribe a nicotine replacement (such as gum or patches) to assist you in quitting smoking. You should begin taking nicotine replacement products on the day that you stop smoking cigarettes or tobacco. Certain people who are taking bupropion (Wellbutrin or Zyban) have experienced extremely high blood pressure, particularly when they are also taking nicotine replacement products (patch or chewing gum). Your blood pressure could need to be monitored prior to and while you are taking bupropion. There is a possibility that you will experience withdrawal symptoms after quitting smoking, which include: an increase in appetite and weight gain; problems getting sleep; difficulty staying focused; a slow heart rate; experiencing the urge to smoke; and experiencing feelings of anxiety, restlessness, or depression. You may also feel angry, annoyed, angry, or even angry. These symptoms can occur regardless of whether you are taking medications such as Zyban.

Quitting smoking may cause an increase in or worsening of mental health issues, including depression. This medication can result in an untrue positive test for drug screening. If you give a urine sample for drug screening, be sure to inform the laboratory personnel that you're taking bupropion. Keep at room temperature, away from heat and moisture.

What Happens If I Miss a Dose?

You should take the dose as soon as you realize you forgot it.  Do not take your missed dose if you are close to the time of the next dose. Don't take more medicine than usual to make up for the one you missed.

What Happens If I Overdose?

For medical emergencies, seek immediate attention and dial for help at the Poison Help line at 1-800-222-1222. A bupropion overdose could be fatal. Overdose symptoms may include muscle stiffness, hallucinations, unsteady or fast heartbeats, deep breathing, or fainting.

What Should be Avoided?

Bupropion and alcohol can increase the risk of having seizures. If you are a regular drinker, discuss this with your doctor prior to adjusting the amount of alcohol you consume. The medication can cause seizures in those who consume a lot of alcohol, only to suddenly stop drinking after they begin taking the drug. Bupropion can affect your ability to think or react. Be aware when driving or doing things that require you to be vigilant.

Side Effects of Bupropion

Get immediate medical attention. If you experience any of the following symptoms warning of an allergic reaction with bupropion: hives, itching or swelling of the glands, trouble breathing, swelling of your throat or face, or a severe skin reaction (fever and burning eyes, sore throat or skin rash, pain, the skin may be red or purple with peeling and blistering),

Inform your physician of any symptoms that are becoming more severe or new, for example, a change in your mood or behavior such as depression, anxiety, or panic attacks, difficulty sleeping, or when you find yourself irritable, moody, or agitated. You may also feel hostile, angry, active, restless, excessively hyperactive (mentally and physically), or more depressed, or you may be thinking about suicide or harming yourself.

Contact your doctor immediately. If you suffer from:

  • A seizure (convulsions)
  • Unusual shifts in mood or behavior
  • Blurred vision blurred vision, swelling, or pain; having halos appear around lights
  • Irregular or fast heartbeats
  • A manic moment involves thoughts racing, excessive energy, feeling extremely joyful or annoyed, talking longer than normal, and severe issues with sleep.

Common side effects of bupropion include:

  • Dry lips; sore throat; congestion of the nose
  • Ears ringing
  • Blurred vision
  • Nausea, stomach pain, vomiting, constipation, and loss of appetite
  • Sleep problems (insomnia)
  • The sensation of sweating, tremors, or tremors; feeling nervous or anxious;
  • Fast heartbeats
  • Confusion, agitation, and hostility
  • Rash
  • Weight loss
  • More frequent urination
  • Headache, dizziness.
  • Joint or muscle pain or joint

This isn't a complete list of all the side effects. Other side effects could occur. Consult your physician to seek medical advice on adverse effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with Other Drugs

There is a higher risk of suffering seizures if you take certain other medications while taking bupropion. Numerous medications can interfere with bupropion. Discuss with your doctor the medicines you take as well as the medicines you are starting or stopping taking during your treatment. This includes over-the-counter and prescription supplements, vitamins, and herbal remedies. The interactions of all medications are included in this guide to medications.



Prescription only

Pregnancy & Lactation

CSA Schedule*
Related Drugs
Related Stories