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Name of the Generic: Bendamustine (BEN-da-MUS-teen) BEN-da-MUS teen“BEN-da-MUS”.
Brand Names: Belrapzo, Bendeka, Treanda.
Class of Drug: Alkylating agents.

What is Belrapzo?

Belrapzo is a treatment for chronic lymphocytic leukemia. It can also be used to treat B-cell indolent non-Hodgkin's lymphoma when other treatments have failed to provide treatment for this disease. Belrapzo is also used for reasons not mentioned in this guideline for medication.

Side effects of Belrapzo

Seek medical attention immediately when you are experiencing symptoms warning signs of an allergic response (hives, breathing difficulties, and swelling in your throat or face) or an extreme skin reaction (fever or sore throat, burning of your eyes, skin irritation, or red or purple itching that can cause peeling and blisters). Consult a doctor in the event of a serious drug reaction that affects various parts of your body. Symptoms may include an itch on your skin or fever, swollen glands, muscle pains, abnormal bruising, severe weakness, or yellowing of the eye or skin. Belrapzo could result in the development of a brain infection that could lead to the loss of a disability or even death. Consult your physician when you are experiencing issues with your speech, thoughts, or vision, as well as movements of your muscles. These signs can become more severe quickly.

Belrapzo may cause serious side effects. Contact your physician immediately. If you suffer from:

  • Chills, fever, and itching within or shortly after the injection.
  • Redness, pain, swelling, skin changes, or indications of infection in the area at the site of injection.
  • Severe ongoing nausea, vomiting, or diarrhea.
  • Liver disorders include right-sided upper stomach pain, vomiting, loss of appetite, yellowing of the skin or eyes, and general malaise.
  • Fatigue,low blood cell counts, fever, chills, fatigue, mouth sores, skin sores, bruising that is easy, abnormal bleeding or pale skin, coldhands, feet and hands and feeling lightheaded and short-tempered.
  • Confusion, weakness, muscle cramps, nausea, vomiting, high or slow heart rate, decreased urine, tingling in your hands and feet or around your mouth are all symptoms of tumor cell disintegration.

The course of your cancer treatment may be delayed if there are certain adverse consequences.

Common adverse effects of Belrapzo include:

  • The fever, itching, and mouth ulcers; difficulty breathing.
  • Low blood cell count.
  • Nausea, vomiting, diarrhea, and constipation.
  • Headache, tiredness.
  • It can be a rash.
  • Loss of appetite and appetite loss, weight gain.

This isn't a complete comprehensive list of all the possible side effects. Other side effects could occur. Contact your physician to seek medical advice on adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.


Contact your doctor immediately if you experience any kind of skin rash following treatment with Belrapzo.

Before you take this drug

You shouldn't be treated with Belrapzo if you are allergic to polyethylene glycol, Belrapzo propylene glycol, or mannitol (Osmitrol).

Speak to your doctor if you have ever suffered from:

  • An immune system that is weak.
  • Fever or other symptoms of infection.
  • Tuberculosis.
  • herpes zoster (also known as "shingles).
  • A metabolic disorder or an electrolyte imbalance.
  • The liver condition.
  • Kidney disease kidney disease.
  • If you smoke.

The use of Belrapzo can increase the chance of getting certain kinds of cancer. Talk to your doctor about this chance. Belrapzo may harm an unborn child as well as cause birth defects when the mother or father is taking this medication.

  • If you're female, do not use Belrapzo when you are expecting. You might need to undergo an unconfirmed pregnancy test prior to taking this medication. Utilize effective contraception to avoid pregnancy while taking this medication and for a minimum of 6 months following the last dose.
  • If you're a male, use effective birth control when your partner is capable of becoming pregnant. Continue using birth control for a minimum of 3 months following the last dose.
  • Contact your physician immediately when you notice a pregnancy when either the mother or the father is taking Belrapzo.

This medication can affect fertility (the ability to have kids) in men. But it is crucial to utilize birth control to avoid pregnancy since Belrapzo could cause harm to an unborn baby. Avoid breastfeeding during the course of this medication and for at least one week following the last dose.

How to take Belrapzo?

Belrapzo can be given as an injection into a vein. Your healthcare professional will offer the injection. Belrapzo is generally prescribed for two consecutive days every 21–28 days. Your physician will decide the duration of treatment with this medication.

There are other medications to reduce certain adverse side effects from bendamustine. Contact your physician if you are experiencing any pain, burning, or swelling in the area of your IV needle after the medication is administered. Belrapzo impacts the immune system. You could contract infections more frequently, even severe or fatal infections. Your doctor should check on you regularly. If you've experienced hepatitis B treatment, Belrapzo can trigger this virus to get active or worse. It's possible to have regular liver function tests when using this drug and for a period of time following its discontinuation.

What happens if I miss a dose?

Contact your doctor for advice. If you do not make an appointment to get your Belrapzo,

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Avoid driving or engaging in hazardous activities until you understand how the Belrapzo medication affects you. Your reaction could be affected.

Interaction with other drugs

It is sometimes not recommended to take certain medications simultaneously. Certain drugs may affect your blood levels and the other drugs you are taking, which could create side effects or render the medication less effective. Discuss with your doctor any other medications you are taking, especially:

  • Allopurinol.

This list isn't complete. Other medications can affect Belrapzo, such as medications that are prescribed and available over the counter, vitamins, and herbal products. There are many possible interactions between drugs, which are listed here.