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Generical name: phendimetrazine [fen di-MEH-tra-zeen] [ fen-di-MEH-tra-zeen
The brand names are: Bontril, Melfiat
Classes of drugs: anorexiants, CNS stimulants

What is Phenendimetrazine?

Phendimetrazine can be described as an amine with a sympathomimetic structure, which is similar to amphetamine. Phendimetrazine increases the activity of your central nervous system (nerves and brain), which increases your heart rate and blood pressure. It also reduces your appetite. Phendimetrazine is a prescription medication that is taken in conjunction with exercise and diet to combat overweight.


Phendimetrazine is not recommended when you suffer from glaucoma, thyroid hyperactivity, heart issues that are severe, uncontrolled blood pressure, severe coronary artery disease, severe anxiety, or a history of use. Do not take this medicine. If you've taken an MAO inhibitor in the last 14 days, including isocarboxazid linezolid, methylene blue injection, or phenelzine selegiline, rasagiline, or tranylcypromine, A potentially dangerous interaction between drugs can occur, causing severe side effects.

Loss of weight during pregnancy may affect the unborn baby, even if you're overweight. Don't use phendimetrazine if you are nursing or pregnant.

Don't stop taking this medication abruptly after the duration of use, or you may experience unpleasant withdrawal symptoms. Discuss with your physician how you can prevent withdrawal symptoms after you stop taking this medicine. Do not chew, crush, break, open, or crack your extended-release capsule. Take it in whole. Opening or breaking the pill could cause too much of the drug to be released in a single dose.

Prior to use this drug

Phendimetrazine should not be used if you have an allergy to the substance or suffer from:

  • Serious heart issues;
  • Advanced coronary arterial pathology (clogged the arteries);
  • Extreme or uncontrolled blood pressure
  • Hyperactive thyroid
  • Glaucoma;
  • Extreme agitation, nervousness, or
  • An addiction history to drugs.

Do not take phendimetrazine if you've taken an MAO inhibitor within the last 14 days. A risky drug interaction may occur. MAO inhibitors are isocarboxazid linezolid Methylene blue injection rasagiline and phenelzine, as well as tranylcypromine and others.

Loss of weight during pregnancy may cause harm to the unborn baby, regardless of whether you're overweight. Do not take phendimetrazine when you are breastfeeding or pregnant. breastfeeding. Tell your doctor immediately if you find yourself pregnant while receiving treatment.

Inform your doctor if you were ever diagnosed with:

  • The heart or the coronary artery
  • High blood pressure
  • Diabetes (your dosage of diabetes medication might require adjustment) as well as
  • An allergy to food dye and an allergy to aspirin

Phendimetrazine is not a drug that has been approved to be used by anyone less than 17 years of age.

How to take Phendimetrazine?

Follow the exact dosage as recommended by your physician. Follow the instructions on your prescription label, and go through all medication guides and instructions. Your doctor may alter your dosage.

The usual dosage is 30 minutes to an hour before eating. Follow the dosing guidelines of your physician extremely carefully. Do not take phendimetrazine in more quantities or for a longer duration than what is prescribed. Taking more of the medication will not improve its effectiveness and could result in severe, life-threatening side effects. Phendimetrazine can be used for a short time only. The effects of the appetite suppressant may fade within a couple of weeks. Phendimetrazine can be a habit-forming drug. Intoxication can lead to dependence, overdose, or even death. Selling or giving the medicine away is a violation of the law.

Get in touch with your doctor right away. If you suspect that this medication isn't working for you or if you have not lost more than 4 pounds in the span of 4 weeks, Don't abruptly stop taking this medication, or you may experience painful withdrawal signs. Consult your doctor about how to be sure to stop taking this medication. Keep the bottle at room temperature, far from heat and moisture. Make sure the bottle is tightly sealed when not being used.

Details on dosage

Usual Adult Dose for Obesity:

105 mg taken orally every day for 30 to 60 minutes before breakfast

35 mg taken in a single dose orally 3 or 2 times per day, 1 hour prior to eating
Maximum dose of 70 mg orally three times a day. One hour prior to meals.

Use as monotherapy only.
Extended-release: The active ingredient contained in each extended-release capsule mimics the effect of three 35-mg doses of immediate-release that are administered at intervals of 4 hours.
Immediate-release: The dosage needs to be tailored to ensure an appropriate response at the smallest dose that is effective. 17.5 mg per dose could suffice in certain situations.

Use: Treatment of exogenous obesity as a short-term addition to the treatment of weight loss that is based on caloric restriction for patients suffering from
A BMI that is 30 kg/m2 or higher
A BMI that is 27 kg/m2 or more in the presence of any other danger factors (e.g., hypertension or diabetes hyperlipidemia) that have not had a response to the appropriate weight reduction regimen (diet or exercise) on their own

What happens if I miss the dose?

Take the medication as quickly as you can; however, take a break from any missed doses later in the daytime. Don't take two doses at once.

What happens if I overdose?

For medical emergencies, seek emergency treatment or contact the Poison Help Line at 1-800-222-1222. A high dose of phendimetrazine could be fatal.

Overdose symptoms can include anxiety, confusion, hallucinations, severe insanity, nausea, vomiting, diarrhea, stomach cramps, being tired or depressed, irregular heartbeats, seizures, a weak pulse, or slow breathing (breathing could cease).

What should be avoided?

Avoid driving and other hazardous activities until you are aware of the effects of phendimetrazine on you. Your reaction could be affected. Consuming alcohol while taking this medication could cause adverse effects.

Side effects of Phendimetrazine

See a doctor immediately. If you are experiencing symptoms of an allergy reaction to the drug phendimetrazine: hives or difficulty breathing and swelling of your lips, face, tongue, throat, or face

Contact your doctor immediately. If you suffer from:

  • Beats of your heart or the sound of fluttering your chest
  • Tremors, severe agitation, feeling restless, trouble sleeping;
  • Strange changes in behavior or mood;
  • Very little or no urine; or
  • Raised blood pressure: The result is an extreme headache, blurred vision, and the pounding of your neck or ears. Stress nasal bleeding.

Common side effects of phendimetrazine include:

  • Flushing (warmth, redness, or a tingly sensation);
  • More sweating or urination;
  • Dizziness, headache;
  • Blurred vision
  • Dry mouth, nausea
  • Diarrhea, constipation, stomach pain, or
  • Increased or decreased the interest in sex.

This isn't a complete list of all the side effects. Others could happen. Consult your physician to seek medical advice on the effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Other medications can affect the effects of phendimetrazine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Discuss with your physician all your medications currently in use and any medication you begin or stop taking.




Prescription only

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