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Generic name: pseudoephedrine and triprolidine [soo-doe-e-FED-rin-and-try-PROE-li-deen]
Brand names: Aphedrid, A-Phedrin, Aprodine, Vi-Sudo, Wal-Act, Histafed
Classification of drugs: upper respiratory combinations

What is Aprodine?

Aprodine is an antihistamine and decongestant medication that treats nasal congestion as well as sneezing, itching, eye watering, and sinus congestion due to allergies or the common cold.Aprodine is also used for reasons not mentioned in this guideline for medication.

Side effects of Aprodine

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms or warning signs of an allergic response, like hives, trouble breathing, and swelling of your lips, face, and tongue.

Aprodine can cause severe adverse effects. Stop using Aprodine immediately and consult your physician immediately in the event that you experience:

  • Severe dizziness;
  • Nervousness;
  • Sleep problems sleep problems;
  • High blood pressure (severe headache and pounding in your neck or ear)

Common aprodine-related side effects could be:

  • Dizziness, drowsiness;
  • Dry mouth, nose, dry mouth, or throat
  • Constipation;
  • Blurred vision
  • Experiencing a sense of anxiety or excitement (especially when it comes to children).

This list does not comprise all potential side effects; additional ones could surface. Contact your doctor for advice regarding medical adverse effects.Report all adverse reactions directly to the FDA by calling their toll free number: 1-800-FDA-1088.


Do not use this medicine to make your child restless. Misuse of this medicine could result in death for young children.

Before you take this drug

You shouldn't take aprodine if you are sensitive to pseudoephedrine or triprolidine.Do not take aprodine in the event that you've used an MAO inhibitor within the last 14 days. A risky drug interaction may occur. MAO inhibitors include isocarboxazid linezolid, methylene blue injection, phenelzine, and tranylcypromine, as well as other MAO inhibitors.

Ask your doctor or pharmacist for a recommendation on whether this medication is suitable for you if you have ever used:

  • Asthma or another breathing disorder such as emphysema, as well as chronic bronchitis;
  • Hypertension, cardiovascular disease;
  • Glaucoma;
  • Diabetes
  • Thyroid disorders are a common problem.

Consult a physician before taking this medication if you are nursing or pregnant.

How to take Aprodine?

Take exactly as indicated on the label or as recommended by your physician. The cold and cough medication is intended for short-term use until your symptoms improve.Use the syringe supplied or a device for measuring doses (not an ordinary spoon).Follow the instructions on the label of the medicine about the administration of cold or cough medicine to children. Don't use the medicine solely to induce sleepiness in a child. Death can occur through the use of cold or cough medicine in children who are very young.Consult your physician if symptoms don't improve after seven weeks of therapy or if you suffer from a fever, headache, cough, or an itchy skin eruption.If you require surgical intervention or tests for medical reasons, inform your doctor or surgeon prior to the time of your appointment if you have taken this medicine in the last few days.Place it in a cool, dry place far from heat and moisture.

What happens if I miss the dose?

Because aprodine can be used as needed, you may not be following a dose schedule. Do not miss any doses when it's time to take the next dose. Be careful to not take two doses at the same time.

What happens if I overdose?

For medical emergencies, seek emergency care immediately or reach out for help at the Poison Help Line (1-800-222-4122).

What should be avoided?

Avoid driving or engaging in hazardous activities until you understand the effects of aprodine. The way you react could be impaired.Consult a physician or pharmacist prior to using any other cold or cough medications that contain similar components.Drinking alcohol can trigger certain adverse effects of triprolidine.

Interaction with other drug

Talk to your doctor or pharmacist prior to using any other medications that could result in sleepiness (such as opioids, sleep medication, a muscle relaxer, or medications to treat anxiety as well as seizures). There are many possible interactions that are not described here.




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