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Amikacin liposome

Generical name: amikacin liposome [AM-i-KAY-sin]
The brand name is: Arikayce.
Form of dosage: inhalation suspension (590 mg/8.4 ML)
Drug class: aminoglycosides

What is the Amikacin liposome?

Amikacin liposome is an antibiotic used to manage Mycobacterium avium complex (MAC) lung diseases in adult patients with little or no options for treatment. Amikacin liposomes can be used in conjunction with various medications.Amikacin liposomes are given only to a select group of adults when other antibiotics fail to eliminate MAC infections after six months of treatment.Amikacin liposome has been approved by the FDA. US Food and Drug Administration (FDA) in the "accelerated" basis. In clinical trials, a few individuals responded to the amikacin liposome. However, more studies are required.Amikacin liposomes may also be used to treat conditions that are not mentioned in this guideline.

Side effects of Amikacin liposome

Amikacin liposomes may cause an allergic reaction severe enough to cause death. Take this medicine off your list and seek emergency medical assistance when you notice symptoms or warnings of an allergic reaction.

  • Wheezing, loud breathing, cough sensation of short breath;
  • Itching, hives, swelling of your lips or tongue;
  • High heart rate feeling lightheaded;
  • The loss of bladder control;
  • Nausea, vomiting, diarrhea, and  stomach cramps;
  • Flushing (sudden heat, redness, or tingly sensation).

Amikacin liposomes can cause severe adverse reactions. Consult your doctor immediately if you suffer from:

  • Ringing in your ears, changes in your hearing
  • Cough (especially in the first few months of the amikacin-based liposome);
  • Difficulties speaking;
  • Dizziness, spinning sensation;
  • A feeling of lightheadedness, as if you're about to pass out.
  • Breathing problems: chest tightness, wheezing breathing problems, shortness, and bleeding from the chest;
  • Kidney issues: little or no urine output; swelling of your ankles or feet; fatigue or sluggishness.

Common adverse effects of amikacin liposomes could include:

  • Fever and coughing, increased the amount of mucus and sore throat;
  • Hoarse voice;
  • Headache, muscle pain, chest discomfort;
  • Nausea, vomiting, diarrhoea;
  • Rash;
  • Weight loss;
  • Feeling exhausted.

There isn't an exhaustive listing of all possible adverse consequences, but other effects may occur. Consult your physician to seek medical advice on the effects. You can report symptoms to the FDA at 1-800-FDA-1088.


Amikacin liposomes can trigger a dangerous allergic reaction. Stop taking amikacin liposomes and seek medical assistance immediately in the event of symptoms like coughing, difficulty breathing, itching or hives, diarrhoea, vomiting, rapid heartbeats, feeling lightheaded, or swelling on your throat or face.Amikacin liposomes can cause breathing difficulties. Contact your doctor if you are experiencing chest tightness, wheezing, coughing, difficulty breathing, fever, or a cough that is accompanied by blood.Certain breathing problems may get more severe when you use amikacin liposomes.

Prior to use this drug

It is not recommended to use this medication if you have an allergy to amikacin liposome or related antibiotics (gentamicin, paromomycin, or neomycin), kanamycin, streptomycin, tobramycin, or paromomycin.

Inform your doctor if you were ever diagnosed with:

  • Asthma, chronic obstructive respiratory illness (COPD), wheezing, asthma, or any other breathing issues;
  • Hearing loss;
  • Vertigo (a spinning sensation);
  • Kidney disease kidney disease
  • An illness of the nerves and muscles, like myasthenia gravis.

Consuming amikacin in its oral form during pregnancy can result in the baby being born deaf. It isn't known if amikacin, as an inhaled medication, could harm a newborn baby. Consult your physician if you are pregnant or planning to be pregnant.It might not be safe to breastfeed while taking this medication. Consult your physician about any potential risks.

How to take Amikacin liposomes?

Follow the directions on the label of your prescription and read the medication guide or instructions sheets. Make sure you use the medicine precisely as directed.Make use of amikacin liposomes only in conjunction with the Lamira Nebulizer. Be sure to read and follow the instructions for use that come with your medication and nebulizer. Consult your physician or pharmacist if you have any questions about these directions.Amikacin liposomes must be stored at room temperature before you use them.It is shaken in the vial (bottle) for 10–15 seconds prior to taking it open and pouring the drug into the nebulizer reservoir.Each vial is intended for only one use. Dispose of it after one use, even if there's some medicine in the bottle.There are different medications if you suffer from asthma, COPD, or other lung conditions. You should continue to use these medications for the duration your doctor prescribes.Amikacin liposome vials should be stored in the refrigerator, and make use of them prior to the end of the date. Do not freeze amikacin's liposome.It is also possible to keep amikacin liposomes in a refrigerator at room temperature for up to four weeks. Get rid of any empty vial that has been stored in a room at a temperature of more than 4 weeks.

Details on dosage

Usual Adult Dose for Mycobacterium avium-intracellulare: Treatment:

590 mg is inhaled through Lamira (TM) nebulizers every day.
Patients using bronchodilators must use the bronchodilator before using this drug.
Pretreatment with beta-2 agonists of short-acting is recommended for patients who have a specific group of patients (e.g., asthma and bronchospasm; chronic obstructive asthma; hyperactive airway diseases).
Use: Patients with only a few or no other treatments for the treatment of Mycobacterium Avium Complex (MAC) lung diseases in a combination antibacterial treatment regimen in patients who do not obtain positive sputum culture results after a minimum of six weeks of multidrug-based background treatment

What happens if I miss the dose?

Do not miss the missed dose, and take your next dose at the normal time. Do not take two doses simultaneously.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Amikacin liposomes can cause dizziness or breathing issues and can affect your reaction. Avoid driving and other hazardous activities until you are aware of the effects this medicine can have on you.

Interaction with other drugs

Amikacin may cause kidney damage, particularly when you are also taking specific medications for cancer, infections, osteoporosis, rejection of organ transplants, intestinal issues, high blood pressure, or arthritis pain (including Advil, Motrin, and Aleve).This list isn't exhaustive. Other drugs can interact with amikacin's liposome. This includes prescription and non-prescription medicines, vitamins, and herbal products. There are many possible interactions between drugs. are listed here.




Prescription only

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