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Generical name: anifrolumab [An-i-FROL’ue-mab “AN-i-FRO
Name of the brand: Saphnelo
Form for dosage: intravenous solution (fnia 300 mg/2 mL)
Drug class: selective immunosuppressants

What is Anifrolumab?

Anifrolumab is used to treat severe to moderate systemic lupus and erythematosus (SLE) in adults who are receiving standard treatment for SLE.Anifrolumab can be used for other purposes not covered in this medication guide.

Side effects of Anifrolumab

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergic reaction, such as a sensation of lightheadedness, hives, or being agitated, difficulty breathing, and swelling of your lips, face, and tongue,It is possible to contract infections more frequently and even severe or fatal illnesses.
Call your doctor immediately if you notice indications of illness, like:

  • Fever, chills, sweats, and muscle pains;
  • Skin sores that hurt, with the sensation of warmth or redness.
  • More frequent urination, burning, or pain as you urinate.
  • Diarrhoea, stomach pain,
  • Cough, shortness of breath.

Anifrolumab can cause serious adverse effects. Contact your physician immediately in case of:

  • Colds, fever, cough with mucus, chest pains, feeling breathless, or
  • Signs of the herpes zoster virus (shingles): skin blisters or sores, itching, burning pain, tingling itching, burning pain, rash on your body or face.

Common adverse effects of anifrolumab could include:

  • Shingles;
  • Cough, difficulty breathing;
  • Symptoms of the cold, like congestion, sneezing, a sore throat,
  • Headache, dizziness, fatigue, and nausea after the medication is injectable.

This isn't a complete list of possible side effects, and other side effects could occur. Consult your physician to seek medical advice on the effects.Report any symptoms to the Food and Drug Administration by calling them on 800-FDA-1088.


Only use it according to the directions. Talk to your doctor if you are taking other medicines or have any other medical conditions or allergies.

Before you take this drug

It is not recommended to treat with anifrolumab in case you are allergic to it.

Speak to your doctor if you were ever diagnosed with:

  • An ongoing or chronic infection;
  • Cancer;
  • Treatment with a biologic medication or monoclonal antibody
  • If you're scheduled, get a vaccination.

Check to ensure that you are up to date on all vaccinations before you begin taking anifrolumab.Consult your physician. If you are pregnant, if you are pregnant, or if you're nursing.If you're pregnant and you are a registered mother, your name could be included on the registry for pregnancy to monitor how anifrolumab affects the infant.Anifrolumab could impact your baby's immune system. However, being diagnosed with SLE during pregnancy could lead to complications such as a worsening of lupus and the condition known as eclampsia (dangerously high blood pressure), preterm births, miscarriages, or growth issues for the baby who is not yet born. A mother's SLE can also trigger lupus or heart issues to manifest in the newborn. The advantages of treating SLE could outweigh the risks for the infant.Not permitted for use by anyone less than 18.

How to take Anifrolumab?

Anifrolumab is injectable into veins by a physician, typically every 4 weeks.Anifrolumab is best administered slowly over the course of 30 minutes.

Details on dosage

Usual Adult Dose for Systemic Lupus Erythematosus:

300 mg IV for 30 minutes each week for 4 weeks
The effectiveness of this drug is not yet evaluated for patients suffering from serious active lupus nephritis or severe central nervous system lupus. so the treatment of these patients is not advised.
For the treatment of adults who suffer from moderate to severe systemic lupus and erythematosus (SLE) and are receiving standard treatment

What happens if I miss the dose?

Consult your physician for the appropriate treatment in the event that you don't make an appointment to receive the injection of anifrolumab.

What happens if I overdose?

Get medical attention in an emergency or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Beware of receiving a "live" vaccine. The vaccine might not work in the same way if you are taking anifrolumab. Live vaccines comprise measles, Mumps, measles, rubella (MMR), the typhoid virus, rotavirus, yellow fever, varicella (chickenpox), and the zoster (shingles).

Interaction with other drugs

Other medications may interact with anifrolumab, such as prescription and non-prescription medications, vitamins, and herbal products. Inform your physician about any other medications you take.