The Web Health


Adapalene Topical

Generic name: Adapalene topical [a-DAP-a-leen-TOP-i-kal]
The Brand Names are Differin and Plixda.
Forms of dosing: topical cream (0.1 percent), topical gel (0.1 percent; 0.3%), topical lotion (0.1 percent).
Drug class: Topical acne agents.

What is Adapalene Topical?

Adapalene is a medication that is similar to vitamin A. It assists the skin in renewing itself.

Adapalene topical (for application on the face) is a treatment for severe acne in people who are twelve years of age.

Adapalene topical is also used for reasons not mentioned in this guideline.

Side Effects of Adapalene Topical

See a doctor immediately. If you are experiencing symptoms that indicate an allergic reaction, such as itching, hives, chest pain, difficulty breathing, and swelling of your lips, face, and tongue,

Adapalene topical could cause serious adverse side effects. Stop using the topical and consult your physician immediately if you suffer from:

  • Skin burns, redness, stinging, or peeling following exposure to the sun.

Certain side effects can be observed during the initial four weeks after taking this medication. These side effects will become less prominent with the use of more medication.

Common side effects of topical adapalene could include:

  • Dry, red, or scaly skin.
  • Sensation of warmth and a mild burning or stinging;
  • Peeling skin.
  • Skin discomfort.

This isn't a complete list of all the side effects. Other side effects could be present. Consult your physician for advice regarding medical adverse effects. You can report any side effects to the FDA at 1-800-FDA-1088.


Follow all the instructions on the label of your medication and on the label of your package. Be sure to inform your healthcare professionals about your medical ailments, allergies, and any medications you take.

Do not apply the topical application of adapalene if you are sensitive to the chemical adapalene.

Consult a pharmacist or doctor to determine whether it is safe to take this medication in the event of any other medical conditions.

It is unclear if adapalene is absorbed into breast milk or whether it can harm breastfeeding babies. Do not take this medication without seeking a doctor's advice if you are breastfeeding.

It isn't known if adapalene could cause harm to an unborn baby. Do not take this medication without seeking a physician's recommendation if you are expecting.

Adapalene is not a drug that is approved for use by anyone less than 12 years of age.

How to Take Adapalene Topically?

Follow the directions on the label or as directed by your physician. Avoid using in larger quantities or for a longer time than suggested. Applying adapalene topical in greater amounts than recommended won't help it work faster and can cause unwanted adverse effects.

Do not consume by mouth. Adapalene is intended for use only on the skin.

Adapalene topical application is generally done every night, at least once.

Cleanse your hands prior to applying this medication.

Cleanse your face with an unmedicated, mild cleanser before applying the cream. Apply a dry towel to the skin. an untidy towel.

Spread a small amount of the cream over the entire face or any other skin areas affected. Be careful not to apply the medication to the wrinkles of your nose as well as on your lips.

Avoid applying to open wounds or on sunburned, windburned, chapped, or irritated skin. Don't apply any other skin care products unless your doctor has advised you to.

Do not get this medicine into your nose, eyes, or mouth.

You can apply an oil-based moisturizer to your skin if it gets dry when using adapalene. Avoid lotions and creams that contain alpha-hydroxy glycolic acids.

It could take a few weeks before you see improvement in your acne, or it could get marginally worse for a brief duration when you first begin using Adapalene. Use the medication exactly according to the directions, even if it's not working.

Consult your physician if the skin problems do not start to improve after 8–12 weeks after taking this medication.

Don't use adapalene for topical application to treat any health issue that hasn't been examined by your physician.

Storage at room temperature, free of heat and moisture. Avoid freezing.

Details on Dosage

Usual Adult Dose for Acne:

Usual dosage Apply a light layer of cream to the affected area every morning before going to bed.

The area affected should be thoroughly cleaned and dried prior to application.
Patients may experience a brief feeling of warmth after applying the cream formula.
A visible exacerbation of acne could occur during the first few weeks of treatment, but that shouldn't be the reason to stop treatment.

Treatment: Topical treatment for acne vulgaris

Usual Pediatric Dose for Acne:

Ages 12 and over:
Dosage for use Apply a thin layer to the affected area every night before going to bed.

The area affected should be thoroughly cleaned and dried prior to application.
Patients might experience a temporary feeling of warmth or stinging following the application of the formulation.
A visible exacerbation of acne can occur in the initial weeks of treatment but shouldn't be the reason to stop treatment.

What Happens If I Miss a Dose?

Take the medication as soon as you can remember. If it's almost time to take your next dose, avoid your missed dose and hold off until the next scheduled dose. Do not take extra medication to replace the missed dose.

What Happens If I Overdose?

Contact emergency medical assistance. If you suspect you've consumed too much of the Adapalene topical, Skin swelling, redness, or irritability

What Should be Avoided?

Avoid exposure to the sun as well as tanning beds. Adapalene may cause the skin to burn more quickly. Be sure to wear protective attire and sunblock (SPF 30 or greater) when outdoors.

Do not use other skin care products that comprise sulfur, resorcinol, and salicylic acid (common in products for acne on the skin or cleansers).

Beware of products for the skin that may cause irritation, like harsh shampoos, soaps, or skin cleanser, hair coloring, permanent chemicals, hair removers, and waxes, as well as skin products made of alcohol, spices, lime, or astringents.

Interaction with Other Drugs

It is unlikely that other medications you take by mouth or inject will affect the adapalene you apply topically. However, many drugs interfere with one another. Be sure to inform your health care professionals about any medications you take, including prescription and non-prescription medications, vitamins, and herbal remedies.