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Generic name: Bupivacaine and meloxicam [byoo-PIV-a-kane-and-mel-OKS-i-kam]
Drug class: Analgesic combinations

What is Zynrelef?

Zynrelef is a medication used by adults to alleviate discomfort for up to 72 hours following certain surgical procedures.Zynrelef can also be used for other purposes not covered in this guideline for medication.

Side effects of Zynrelef

Seek medical attention immediately when you are experiencing symptoms that indicate an allergic reaction (hives or breathing difficulties and swelling of your throat or face) or a severe reaction to your skin (fever and sore throat, eye burning, irritation, red or purple itching, blistering, and peeling).

Get medical attention when you experience a severe drug reaction that could affect various parts of your body. Symptoms may include the appearance of a skin rash or fever, swollen glands, muscle aches, abnormal bruising, severe weakness, or a discoloration of your eyes or skin.

Zynrelef could cause serious adverse reactions. Contact your physician immediately. If you suffer from:

  • Low red blood cells (anemia)--pale skin and fatigue, feeling lightheaded or tired, cold hands and feet;
  • Issues with the liver: loss of appetite, stomach discomfort (upper right side), fatigue, itching, the dark color of urine, stools with clay, jaundice (yellowing of the eyes or skin);
  • Stomach bleeding—bloody or tarry stools and coughing up blood—or vomit that appears like coffee grounds
  • Chest discomfort, shortness of breath, weakening of the chest, chest pain, or slurring of speech or
  • Pale, gray, or blue-colored complexion; fatigue; fast heartbeat; breath shortness; lightheadedness; or fatigue

Common negative side effects of Zynrelef could be:

  • Constipation, vomiting,

This isn't an exhaustive list of all the side effects. Others could happen. Contact your doctor to seek medical advice on adverse effects. You can report any symptoms to the FDA at 1-800-FDA-1088.

Similar/related drugs

Fentanyl, ketorolac, Toradol, Bupivacaine, Sublimaze, and Toradol IV/IM


Zynrelef may increase the chance of suffering a fatal cardiac attack as well as a stroke. Avoid using Zynrelef prior to or following the heart bypass surgery (coronary bypass grafts for artery CABG, also known as This medicine can cause stomach or intestinal bleeding, which could be fatal.

Before you take this drug

You shouldn't make use of Zynrelef in the event that you are allergic to it or have previously experienced one asthma attack or a severe allergic reaction following using aspirin or an NSAID.

Zynrelef increases the chance of having a fatal heart attack or stroke, even if you do not have any risk factors. Avoid using this medicine prior to or following the procedure to bypass your heart (coronary bypass grafts for the artery CABG, or CABG).

Zynrelef can also trigger diarrhea or stomach bleeding, which could be fatal. These problems can develop in a matter of minutes while taking this medication and are more common among older adults.Zynrelef is not utilized as an anesthetic for tissues surrounding the cervix.

Speak to your doctor if you were ever diagnosed with:

  • The kidneys or liver illness;
  • Heart diseases, high blood pressure, smoking
  • A stroke, a heart attack, or a blood clot
  • Anemia (low levels of red blood cells);
  • The bleeding or ulcers in your stomach;
  • Asthma
  • Fluid retention.

Consult your physician if you are expecting or planning to be pregnant. Zynrelef can harm an unborn child if taken after 20 weeks or later during the pregnancy. If you're between 20 and 30 weeks of pregnancy, you must apply this medication if your doctor has advised you to. Beware of using this medication when you are over thirty weeks pregnant.

Check with your doctor for advice on whether it is safe to breastfeed while taking this medication.

How to take Zynrelef?

Zynrelef will be administered by a medical professional. You'll receive Zynrelef in a medical setting.

Zynrelef causes a temporary loss of sensation at the surgical area.Your heart rate, blood pressure, or any other vital sign will be closely monitored.

Do I be concerned if I miss a dose?

In a medical environment, you will not be prone to miss the dose.

What will happen if I take excessively?

Because Zynrelef is administered in a medical environment, it is monitored carefully to ensure that you don't receive excessive amounts of Zynrelef. The healthcare professional will promptly take care of you if you exhibit symptoms of an overdose.

What should be avoided?

Beware of drinking alcohol. Consumption of alcohol that is too high could increase the risk of stomach bleeding.Beware of taking aspirin when you're using Zynrelef at all times, except when your physician recommends it.

Talk to your doctor or pharmacist prior to using any other medications to treat swelling, fever, pain, or cold or influenza symptoms. They could contain ingredients that are similar to Zynrelef (such as aspirin, ibuprofen, ketoprofen, and naproxen).

Interaction with other drugs

Discuss with your doctor any other medications you take, including:

  • A blood thinner—Warfarin, Coumadin, Jantoven;
  • An antidepressant
  • Blood pressure medication or heart medication, such as diuretics or "water pills";
  • Lithium;
  • Methotrexate;
  • Cyclosporine
  • Pemetrexed.

This list isn't complete, and other drugs could influence Zynrelef. These include prescription as well as over-the counter supplements, drugs, vitamins and herbs. The interactions of all drugs are listed here.