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Zilretta Injection

Name of the Generic: Triamcinolone acetonide (injection) (injection) TRYE-amSIN-oh’lone [ TRYE-am-SIN-oh-lone
Drug Class: Glucocorticoids

What is Zilretta injection?

Zilretta can be described as an extended-release corticosteroid injection that is used to treat knee osteoarthritis pain.Zilretta is a direct injection into the knee. It should not be administered via any other method of injection.Zilretta injections are not appropriate for use on joints with small sizes, like the hand.The potential risks and benefits of repeat injections haven't been proven.

Side effects of Zilretta

Get immediate medical attention. If you show symptoms of an allergy reaction, such as difficulty breathing, hives, and swelling of your lips, face, and tongue,

Zilretta may cause serious side effects. Consult your physician immediately. If you suffer from:

  • After injection into the joint) an increase in pain or swelling, joint stiffness, fever, and a general feeling of ill-feeling;
  • Blurred vision blurred vision, pain in the eyes, or seeing halos of light sources;
  • Unexpected changes in behavior or mood;
  • Swelling and weight gain; rapid sensation of being short of breath;
  • Stomach pains, nausea, diarrhea, bloody or tarry stools, constipation,
  • Suddenly numbness or weakening (especially in an individual side);
  • A seizure (convulsions);
  • Extreme headache severe headache, blurred vision the pounding in your neck or in your ears;
  • Increased pressure within the skull; severe headaches the ear-ringing dizziness nausea and vision issues eye pain
  • Indicators of hormones in the adrenal glands that are not functioning properly. The signs of adrenal gland hormones being deficient are symptoms of low adrenal gland hormones, like headaches, depression, fatigue, weakness, diarrhea, vomiting, stomach discomfort, craving salty food, and feeling lightheaded.

Certain adverse reactions are more likely to happen with long-term usage or frequent treatments of Zilretta injection.

Steroids can affect growth in children. Inform your doctor if your child isn't growing normally when taking this medication.

Common Zilretta side effects may include:

  • Skin changes (acne dryness) skin changes (bruising, redness, discoloration);
  • The growth of hair is increased, or thinning hair
  • Nausea, bloating, and appetite changes;
  • Side or stomach pains;
  • Cough, nasal stuffiness, or a runny nose;
  • Headache, sleep problems (insomnia);
  • A wound that is slow to heal
  • Is sweating greater than the norm
  • Changes in your menstrual cycle.

This is not a comprehensive list of possible side effects, and others could happen. Contact your doctor for advice regarding medical adverse effects. You can report any symptoms to the FDA at 1-800-FDA-1088.

Similar/related drugs

aspirin, prednisone, ibuprofen, meloxicam, naproxen, and Cymbalta


There is a chance that you won't be able to get Zilretta when you suffer from a fungal illness or have an illness known as idiopathic purpura (ITP).

Before you take this drug

It is not recommended to treat with Zilretta if you have an allergy to triamcinolone.

There is a chance that you won't be able to get Zilretta injections if you suffer from a fungal infection or have an illness known as idiopathic purpura (ITP).

Inform your doctor if you have ever suffered from:

  • An ongoing or chronic disease an ongoing or chronic infection, which includes tuberculosis;
  • Idiopathic thrombocytopenic purpura (itp);
  • Hypertension and heart problems
  • Cataracts, glaucoma, and herpes infections of the eyes.
  • An infection caused by a parasite that causes the condition of diarrhea (such as with threadworms);
  • An illness of the nerves and muscles, like myasthenia gravis;
  • A stomach ulcer, diverticulitis, or ulcerative colitis;
  • A colonostomy or ileostomy, the stomach operation;
  • Low bone mineral density,
  • A thyroid issue or the adrenal gland.

Talk to your physician if are nursing or expecting.

How to take a Zilretta injection?

Zilretta injections are given by a healthcare expert as a single injection of triamcinolone acetonide directly into the knee joint.

Triamcinolone is known to reduce (suppress) the immune system, and you could contract an infection faster. Consult your physician if you are experiencing unusual bleeding or bruising or any indications of an infection (fever weakening, cold or flu symptoms, skin sores, diarrhea, frequent or repeated disease).

Your physician may advise you to reduce your intake of salt when you are receiving Zilretta injections. It is also possible to supplement your potassium intake with potassium supplements. Follow all directions.

Triamcinolone could alter the results of certain medical tests. Inform any physician who treats patients that you're using Zilretta.

Details on dosage

Usual Adult Dose of Zilretta for Osteoarthritis:
Extended-release: 32 mg/5 mL:
For osteoarthritic knee pain, just 32 mg is the recommended dose in a single intra-articular injection.
The efficacy and safety of repeated administration have not been determined.
If a large quantity of synovial fluid is present within the joint, you can aspirate it in a small amount (not completely) to relieve pain and prevent excessive dilution of the steroids.
Zilretta is not recommended for use in joints with small sizes, like the hand. It is recommended for osteoarthritis of the knee.

What happens if I miss a dose?

Contact your physician for advice. If you don't make an appointment to receive a Zilretta injection,

Since Zilretta is one dose, you won't be following a regular dose schedule.

What happens if I overdose?

Because Zilretta is prescribed by a medical professional in a medical environment, it is highly unlikely for an overdose to be a problem.

Utilizing excessive amounts of Zilretta is unlikely to cause any serious issues. However, prolonged consumption of high doses may cause thin skin, easily bruising, modifications in the body's fat (especially around your neck, face, back, waist, and face), increased facial hair or acne, menstrual disorders, impotence, or a loss of interest in sexual activity.

Avoid this

Following the injection of Zilretta into the joint in your knees, be careful not to use the joint too much during strenuous activities or sports with high impact. It is possible to cause injury to the joint.

Beware of those with illnesses or who suffer from infections. Contact your doctor to receive preventive care in the event that you have been affected by chickenpox or measles. These illnesses can be very serious and even fatal for those who use triamcinolone.

Don't receive the "live" vaccine or a toxoid vaccine when you are using Zilretta, as you may contract a severe illness. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and the nasal flu (influenza) vaccine. Toxoid vaccinations include diphtheria as well as toxoid tetanus (DT, also known as Td).

Interaction with other drugs

It is sometimes not recommended to take certain medicines together. Certain medications can alter the blood levels of other medications you are taking, which could create side effects or render the medication less effective.

Inform your doctor about the medicines you are currently taking. Certain drugs can interact with triamcinolone. This includes:

  • As an antimicrobial or antifungal medication.
  • Birth pills for control and hormone therapy
  • The blood thinners (warfarin, coumadin, and many more);
  • Diuretic or "water pill";
  • Insulin or oral diabetes medicine;
  • Treatment for tuberculosis with medicine;
  • An anti-inflammatory nonsteroidal drug, or nsaid (aspirin, ibuprofen, naproxen, diclofenac, indomethacin, advil, aleve, celebrex, and many others), as well as
  • Seizure medication.

This is not a complete list, and other drugs could influence Zilretta. This includes prescription and over-the-counter medications, vitamins, and herbal products. There are many possible interactions between drugs that are listed here.