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Generical name: duloxetine duloxetine du-LOX-e-teen du-LOX-e-teen
Drug class: Serotonin-norepinephrine reuptake inhibitors

What is Cymbalta?

Cymbalta is an SSNRI, which stands for selective serotonin norepinephrine- (SSNRI). Duloxetine influences the production of chemicals within the brain that could be out of balance in those suffering from depression. Cymbalta is a medication used for treating major depression disorder for adults. It can also be utilized for treating general anxiety disorders for children and adults that are at least 7 years old. Cymbalta can also be used by adults to relieve nerve pain that is caused due to the disease diabetes (diabetic neuropathy) or chronic joint discomfort (such such as low back joint pain or osteoarthritis pain). Cymbalta can also be used to treat the condition known as fibromyalgia (a persistent pain condition) in children and adults aged at least 13 years.


Do not use Cymbalta for 5 consecutive days prior or 14 days following the time you've used the MAO inhibitor, like linezolid, isocarboxazid and phenelzine rasagiline or selegiline or tranylcypromine or methylene blue injection. Cymbalta shouldn't be used in the case of narrow-angle glaucoma.

Many young people are prone to thoughts of suicide after they first start taking one of the antidepressant. Be aware of fluctuations in moods or the symptoms. Be sure to report any new or deteriorating symptoms to your physician for example changes in mood or behavior such as anxiety and panic attacks, problems sleeping, or if find yourself irritable, impulsive and agitated. active, restless, overly active (mentally and physically) and more depressed or are contemplating suicide or harming yourself.

Prior to use this drug

It is recommended not to take Cymbalta if you have an allergy to duloxetine. Do not use Cymbalta in the 5 days prior to or 14 days following the time you've taken the MAO inhibitors, like isocarboxazid and linezolid. Also, avoid methylene blue injections, phenelzine, or tranylcypromine. A drug interaction that is dangerous may occur.

Consult your doctor if you are taking any stimulant medicines, such as opioids and herbal products or medicines, to treat mental illness, depression, or Parkinson's disease. Also, you may have chronic infections or want to prevent vomiting and nausea. Duloxetine interactions could result in a serious illness known as serotonin syndrome. Cymbalta has not been approved for use by anyone less than 7 years old. To ensure that this medication is appropriate for you, consult your doctor if:

  • Heart issues, high blood pressure;
  • Kidney or liver disease;
  • Slow digestion;
  • A seizure;
  • Bleeding issues;
  • Sexual issues;
  • Narrow-angle glaucoma;
  • bipolar disorder (manic depression);
  • addiction to drugs or suicidal ideas; or
  • If you consume a lot of alcohol,

People suffering from mental illness or depression might contemplate suicide. Young people might experience more suicidal thoughts after beginning treatment for depression. Keep an eye on any changes to your mood or the symptoms. Family members or caregivers should be watching for any sudden changes in your behavior.

The use of an SNRI antidepressant at the end of your pregnancy can increase the risk of bleeding excessively after birth and can result in serious medical issues for the newborn. However, stopping the drug could be risky when you are experiencing a relapse of depression. Do not begin stopping this medication without consulting with your doctor.

If you're pregnant and you are a registered mother, your name could be included on an ob-gyn registry to monitor Duloxetine's effects on your baby.

If you're breastfeeding, consult your doctor if you experience fatigue, problems with feeding, or a slow weight gain for the baby who is nursing.

How to take Cymbalta?

Use Cymbalta exactly as directed by your physician. Follow the directions on your prescription label, and go through all the medication guides or instructions. Your doctor may modify your dose.

Utilizing Cymbalta in greater doses or for longer periods than recommended will not increase the effectiveness of the medication, as it may increase the risk of adverse negative effects. Take the capsule in its entirety and avoid crushing, chewing, breaking, cracking, or even cracking it. Eat with or without. Your blood pressure is likely to be checked regularly.

Talk to your doctor if there are any changes in your sexual function, such as loss of interest in sexual activity, difficulty having an orgasm, and (in males) issues with erections or ejaculation. There are some sexual issues that are treatable. Your symptoms might not get better for up to four weeks. Don't stop taking duloxetine at once, or you may experience unpleasant side effects (such as anxiety, confusion, tingling, or electric shock symptoms). Talk to your doctor prior to stopping the medication.

Place it in a cool, dry place far from heat and moisture.

Details on dosage

Usual Adult Dose for Depression:

Initial dosage: 20 mg–30 mg orally twice each day.
Maintenance dose: 60 mg a day, taken every day, or 30 mg orally two times each day.
Maximum dose: 120 mg/day.

Usual Adult Dose for Fibromyalgia:

Initial dosage: 30 mg orally daily for at most one week
Maintenance dosage: 30–60 mg once orally, every day.

Usual Adult Dose for Generalized Anxiety Disorder:

Initial dosage: 60 mg orally at least once per day.
Maintenance dosage: 60–120 mg taken orally every day.
Maximum dose: 120 mg/day.

Usual Adult Dose for Pain:

Initial dosage: 30 to 60 mg once orally every day.
Maintenance dosage: 60 mg every day.

Usual Adult Dose for Neuropathic Pain:

Initial dosage: 30–60 mg once orally every day.
Maintenance dosage: 60 mg taken orally every day.

Usual Adult Dose for Chronic Pain:


Initial dose: 30–60 mg taken orally, once a day.
Maintenance dosage: 60 mg taken orally at least once per day.

Usual Geriatric Dose for Generalized Anxiety Disorder:

Initial dose: 30 mg taken orally every day for a minimum of 2 weeks
Dosage for maintenance: 60 mg orally, twice per day.
Maximum dose: 120 mg/day.

Usual Pediatric Dose for Generalized Anxiety Disorder:

7–17 years old:
Initial dosage: 30 mg daily, orally for at least 2 weeks
Maintenance dose 30–60 mg taken orally, once per day
Maximum dose: 120 mg/day.

Usual Pediatric Dose for Fibromyalgia:

Age 13 and over:
Initial dose: 30 mg taken orally every day for a minimum of one week.
Maintenance dose: 30–60 mg once orally per day.

What happens if I miss the dose?

Do not take the medicine for as long as you can. However, avoid any missed doses if you are nearing the time to take the next dose. Don't have two doses at one time.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help Line at 1-800-222-1222.

Overdose symptoms may include vomiting, dizziness or drowsiness, seizures, fast heartbeats, fainting, or coma.

What should be avoided?

Talk to your physician prior to using a nonsteroidal anti-inflammatory medication (NSAID) like naproxen, aspirin, ibuprofen, Advil, Aleve, Motrin, and many more. Utilizing an NSAID that contains duloxetine could cause bleeding or bruises easily.

Avoid driving and other hazardous activities until you are aware of the effects of this medication on your body. Your reactions may be impaired. A fainting or dizziness could cause accidents, falls, or even severe injuries. Be careful not to get up too quickly from a lying or sitting position. You could get dizzy.

Drinking alcohol can increase the chance of suffering from liver problems, especially if you are taking Drizalma.

Side effects of Cymbalta

Get immediate medical attention. If you are experiencing symptoms warnings of an allergy reaction (hives or breathing problems or swelling of your throat or face) or an extreme skin reaction (fever and sore throat, burnt eyes, irritation, as well as a red or purple eruption with peeling and blisters),

Inform your physician right away if you notice any recent or sudden changes in your mood or behavior, which include more or less severe anxiety, depression, panic attacks, trouble sleeping, or being irritable, angry, or agitated. active, restless, or more talkative or active, or you are contemplating suicide or harming yourself.

Contact your doctor immediately in the event that you are suffering from:

  • Heartbeats that pound or flutter in your chest
  • A feeling of lightheadedness that makes you feel like you're passing out;
  • Easily bleeding, unusual bruises;
  • Vision change;
  • Uncomfortable or difficult to urinate;
  • Liver issues Upper stomach right-sided discomfort, itching, black blood, jaundice (yellowing of the eyes or skin);
  • Low blood sodium, headache and confusion, or problems with memory or thinking weakness, unsteadiness, or
  • Manic episodes of racing thoughts, higher energy levels, a decreased need for sleep, a risk-taking behavior, or being anxious or agitated

Get immediate medical attention. If you experience signs that suggest serotonin syndrome, for example, hallucinations, agitation, sweating chills, shivering, rapid heart rate, stiffness of muscles, twitching, loss of coordination, nausea, vomiting, or diarrhea,

Common cymbalta adverse effects could be:

  • Drowsiness;
  • Dizziness, constipation, and lack of appetite
  • Dry mouth or
  • More sweating.

This is not a comprehensive list of all side effects. Other side effects could be present. Consult your physician for advice regarding medical adverse effects. You can report any symptoms to the FDA at 1-800-FDA-1088.

Interaction with other drugs

There are times when it's not recommended to use certain medicines in combination. Certain medications can alter the blood levels of the other drugs that you are taking. This could cause more side effects or make the medication less effective.

Consult your physician before using a nonsteroidal anti-inflammatory medication (NSAID) like naproxen, ibuprofen, aspirin, Advil, Aleve, Motrin, and many more. When you take an NSAID together with Cymbalta, it can cause bleeding or bruises easily.

Numerous drugs may interact with duloxetine. This includes over-the-counter and prescription medicine, vitamins, and herbal supplements. Not all interactions are included in this article. Inform your doctor about any other medications you take.