What is Votrient?
Votrient is a medicine for cancer that blocks the spread and growth of cancerous cells in the body. Pazopanib is a treatment for cancer that blocks the spread and growth of cancerous cells within the body. Votrient is a treatment for advanced renal cell cancer (kidney cancer).
Votrient is also used to help treat soft tissue sarcoma (a tumour that may grow within or around muscles, joints, tendons, and blood vessels).
Votrient is generally prescribed after other cancer treatments have been tried but with no success. treatment of sarcomas of the soft tissue
Warnings
You shouldn't make use of Votrient in the case of serious liver disease. Pazopanib could cause serious or life-threatening liver conditions. You will need frequent blood tests to assess the liver's function.
Contact your doctor immediately if you experience: nausea, vomiting, lower stomach discomfort, loss of appetite, fatigue, bruising that is easy to heal, dark urine, or jaundice (yellowing of the eyes or skin).
Votrient may decrease blood cells, which help fight illnesses and aid in blood clotting. It is possible to contract an infection or bleed more quickly. Consult your physician if you notice unusual bleeding or bruising or symptoms of an infection (fever, chills, fever, and body discomforts).
Before you start taking this medicine.
To ensure Votrient is safe for you, ask your doctor if you've previously had:
- Liver disease;
- Heart disease, heart rhythm disorder, Long QT syndrome,
- High blood pressure;
- A stroke or blood clot;
- A thyroid disorder
- Headaches, seizures, or vision problems;
- Perforations (a tear or hole) in the stomach or intestines of your
- A fistula (an abnormal passageway) in the stomach or intestines of your body;
- The bleeding of the stomach or the intestinal tract; or
- An operation within the last seven days.
You might need to undergo a pregnancy test that is negative prior to commencing this treatment.
Do not take Vitamin D when you are pregnant. It could harm the unborn baby. Make sure you use effective birth control methods to stop pregnancy while taking this medication and for at least two weeks following your last dose.
If you're male and your partner is pregnant or may be pregnant, use condoms while taking Votrient and for at least two weeks following the last dose. It is recommended to use condoms after having undergone a vasectomy.
It is not recommended to breastfeed while you take Votrient or for a minimum of two weeks following the last dose.
Similar/related drugs
- Keytruda,
- Avastin,
- Pembrolizumab,
- Nivolumab,
- Bevacizumab,
- Doxorubicin, and
- Afinitor
How to take Votrient?
You should take the Votrient exactly as prescribed. Follow the instructions on the prescription label and make sure you read all the directions or guides to your medication. Your doctor may modify your dosage.
Use Votrient in the absence of a stomach at least one hour prior to or two hours following an eating event.
Suck the tablet completely and don't crush, chew, or break it.
Votrient could cause severe or life-threatening liver infections, issues, or hypertension. It is recommended to have regular medical tests.
If you are going to undergo surgery, inform your surgeon in advance that you're taking pazopanib. You might have to stop taking the medication for at least 7 days prior to the surgery.
Keep the nutrient in a cool, dry place far from heat and moisture.
Details on dosage
Usual Adult Dose for Renal Cell Carcinoma:
800 mg taken orally every day, without food. At least 1 hour prior to or 2 hours after the meal.
Comments:
Limitation Effects: The effectiveness of the drug to treat adipocytic soft tissue sarcoma or intestinal stromal tumours has not been proven.
The dosage must not exceed 800 mg.
Swallow the tablets whole, accompanied by water. Don't crush or break due to the possibility of increased absorption, which could affect systemic exposure.
Do not miss a dose if less than 12 hours have passed until the next dose comes in.
Do not consume grapefruit or grapefruit juice since it could increase the concentration of this drug in the plasma.
There is no particular remedy to prevent overdosage with the medication. The treatment should include general measures of support.
Uses: The most common uses are advanced renal cell cancer (RCC) and advanced soft tissue sarcoma (STS) in combination with chemotherapy prior to the diagnosis.
Usual Adult Dose for Soft Tissue Sarcoma:
800 mg taken orally every day, without food. At least 1 hour prior to or 2 hours following a meal
Limitation of Use: The effectiveness of the drug to treat adipocytic soft tissue tumours or intestinal stromal tumours has not been established.
The dose shouldn't be over 800 mg.
Swallow the tablets whole, accompanied by water. Don't crush or break them due to the possibility of increased absorption, which could impact your systemic exposure. Do not take missed doses that are less than 12 hours before your next dose.
Avoid grapefruit or grapefruit juice because it can increase the levels of the drug in your blood.
There isn't a specific remedy for an overdose of the medication. The treatment should include general measures of support.
Uses The most common uses are: Advanced renal cell cancer (RCC) Advanced soft tissue sarcoma (STS) along with previous chemotherapy
What happens If I miss a dose?
Utilise the medication as soon as you are able, but take a break from your missed dosage if the scheduled dose is due to be taken in under 12 hours. Don't use two doses at once.
What happens if I overdose?
For medical emergencies, seek emergency medical attention or contact the Poison Help line toll-free at 1-800-222-1222.
What should be avoided?
Grapefruit can interact with pazopanib and cause adverse side effects. Do not use products made from grapefruit.
Consult your physician prior to using an anti-inflammatory. Don't use an antacid within a couple of hours before or following the use of Votrient. Do not take the stomach acid-reducing drugs (Axid, Nexium, Pepcid, Prevacid, Prilosec, Protonix, Tagamet, Zantac, and Zegerid) while taking Votrient.
Side effects of Votrient
See a doctor immediately. If you are experiencing indications for an allergic reaction, such as hives, breathing problems, and swelling of your lips, face, and tongue,
Contact your physician or seek medical assistance in an emergency. If you are experiencing warning signs of potentially high blood pressure. These include extreme chest pain, a severe headache, blurred vision, an aching in your ears or neck, anxiety, breathing problems, or feeling as if you're going to faint.
See your doctor right away. If you are suffering from:
- Headache, confusion, change in mental status, vision changes, seizure;
- A sudden chest pain with wheezing and a dry cough;
- Unusual bleeding or bruising
- Any surgical or other wound that is not healing;
- Heartbeats that are fast or rapid, the chest fluttering, and a sudden feeling of dizziness (like you're about to faint);
- Heart-related problems - swelling and weight gain rapid Feeling short of breath and swelling;
- Liver issues nausea, vomiting, stomach discomfort, and loss of appetite. Nausea, dark urine, and jaundice (yellowing of the eyes or skin).
- Symptoms of infection include fever, nasal congestion, sore throat, and muscle aches. Skin sores, burning, or pain during urination;
- Symptoms for stomach bleeding: stomach pain or swelling, bloody or tarry stool bleeding blood, coughing up blood, or vomit that resembles coffee grounds.
- Warning signs of heart attacks symptoms include chest pain or pressure, a pain that spreads into your shoulder or jaw nausea, sweating, and vomiting
- Indications of a stroke or a blood clot: sudden numbness, weakness, intense headache, slow or slurred speech, chest pain, vision problems, sudden breath shortening, a numbness or cold sensation in the arm or leg,
- Symptoms of a tumour cell's breakdown: fatigue, weakness, muscle cramps, nausea, vomiting, diarrhoea, and a fast, as well as a moderate heartbeat and tingling sensations on your feet, hands, and around the mouth.
Liver issues are more common in people over 65.
Common nutrient adverse effects could be:
- Nausea, vomiting, diarrhea, and stomach pain;
- Loss in appetite; reduction in weight;
- Trouble breathing
- Tumour pain, bone pain, muscle pain;
- Fatigue, headache;
- Variations in hair or skin colour change in hair or skin colour
- Shifts in your sense of taste
This isn't a complete list of all the side effects. Others could happen. Consult your physician for advice regarding medical adverse effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.
Interaction with other drugs
Inform your doctor about any other medications you take, including:
- As an antibiotic;
- An antidepressant
- Cholesterol medication that has simvastatin (zocor, vytorin, juvisync, and simcor);
- Heart rhythm medication
- Hiv and aids medicines or
- Stomach acid reducers like nexium, prilosec, tagamet, and many others.
