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Generic name: epoprostenol [E-poe-PROST-en-ol]

Brand name: Flolan, Veletri
The class of drugs: agents for hypertension in the pulmonary system

What is Veletri?

Veletri is one of the prostaglandins (a hormone-like substance that occurs naturally in the human body). Prostaglandins assist in controlling certain functions of the body, including blood pressure and muscle contractions.

Veletri can be used for treating the symptoms of pulmonary arterial hypertension (PAH) and to improve your capacity to exercise.Veletri can also be used for other purposes not covered in this medication guide.

Side effects of Veletri

Contact a medical professional immediately in the event that you exhibit warning signs of an allergic reaction, such as symptoms of hives, breathing difficulties, or swelling of your lips, face, and tongue.

Veletri can cause severe adverse effects. Consult your physician right away. If you suffer from:

  • Breathlessness with weakness or dizziness;
  • A lightheaded sensation, similar to what you're passing out;
  • Easy bleeding unusual bleeding
  • Symptoms of pulmonary oedema: anxiety pale skin, sweating symptoms of pulmonary oedema include anxiety, pale skin, extreme shortness of breath, wheezing, gasping to breathe, a cough that is thick with foamy mucus, chest pains that are unsteady, or a fast heart rate.

Common negative side effects of Veletri could include:

  • Flushing (warmth or redness, or a tingly sensation);
  • Dizziness;
  • Nausea, vomiting, diarrhea, and  stomach pain;
  • Trouble breathing
  • Headache, jaw pain;
  • Heartbeats that are slow or fast
  • Muscle or joint muscle;
  • Flu-like symptoms;
  • Being anxious or nervous.

This is not a comprehensive list of possible side effects, and other side effects could be present. Contact your physician to seek medical advice on the effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.


You shouldn't take Veletri in the event of lung fluid or heart insufficiency due to a decline in the heart's capacity to pump blood back into your body.

Before you take this drug

It is not recommended to use Veletri if you have an allergy to the product or are suffering from

  • The lungs are filled with fluid (pulmonary oedema) (pulmonary oedema)
  • Congestive heart failure is caused by a decline in the heart's capacity to pump blood back into your body.

Inform your doctor if you experienced breathing difficulties during your use of Veletri.It is unclear if this medication could affect a newborn baby. Inform your doctor if you are expecting or planning to be pregnant.It is not recommended to breastfeed while taking this medication. Consult your physician regarding any risks.

How to take Veletri?

Follow all instructions on the prescription label and also read all medication guides or instructions sheets. Make sure you use the medication according to the directions. You might need to use Veletri for a long time.The dosage in the clinic or hospital setting will swiftly deal with any severe reactions. Your heart rate and blood pressure could also be checked every time your dose is altered.

Veletri is administered using an infusion pump. It is usually done through a permanent central (IV) catheter that is inserted in a large vein, such as the one in your chest. Your healthcare professional will administer the first dose and guide you on how to administer the medication on your own.Take note of and follow the instructions for use that come with your medication, which might differ between kinds of epoprostenol. Don't use Veletri in the event that you are unable to comprehend the proper usage instructions. Talk to your pharmacist or doctor for any questions.

Make sure to prepare your injection when you're ready to administer it. Don't use it when the medication has changed color or contains particles. Consult your pharmacist about new medications.It is not advisable to stop taking Veletri immediately, even though you feel good. The sudden stop could increase the severity of your condition.

Contact your physician if your symptoms don't improve or if they become worse.In order to ensure that there is no interruption to treatments, it is recommended that you might require a backup infusion pump, battery replacement, and additional IV sets. Make sure you refill your prescription before the expiration date of the medication.Keep Veletri powder within its original packaging in a cool, dry place and away from heat, moisture, and light.

After mixing the medication, you'll need to take it within the specified time frame or days. It will be contingent on the amount of mixture, the diluent you use, and whether you keep the mix at room temperature or inside a fridge. Be sure to follow the mixing and storage directions that are included with your prescription.Reach out to your pharmacist if you have any queries.Keep the mixed medicine safe from direct light at all times when it is stored or being used.

Use a needle or syringe just once, and then put them into the puncture proof "sharps" container. Make sure you follow local or state laws regarding how to dispose of the container. Make sure it is out of reach of pets and children.

What happens if I miss the dose?

Since Veletri is available round the clock, you must be sure to not skip a dose as long as you follow the instructions. Contact your doctor immediately when you experience any problems with your Veletri therapy being interrupted due to reasons of any kind.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Beware of using an infusion pump that hasn't been approved by your physician.

Interaction with other drug

Inform your doctor about your other medications, including:

  • Diuretic or "water pill";
  • Blood pressure medication
  • A blood thinner—Warfarin, Coumadin, Jantoven

This list isn't complete. Other medications could influence Veletri, such as medications that are prescribed and available over the counter, vitamins, and herbal products. There are many possible interactions between drugs that are listed here.