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The generic name is rolapitant (oral tablets) (Roe-LA-pi-tant)

Class of drugs: NK1 receptor antagonists

What is Varubi?

Varubi stops the chemical reactions within the body that cause nausea and vomiting.Varubi is used in conjunction with other medications to stop vomiting and nausea caused by chemotherapy for cancer.

It isn't known whether Varubi is secure and efficient for children.


Varubi may trigger a swift and severe allergic reaction that can be severe and rapid. Consult your physician in the event that you have an allergy history to any medicine or food.

Follow all the instructions on the label of your medication and the package. Be sure to inform your health care providers about your medical ailments and allergies, as well as any medications you take.

Before you take this drug

Certain medications can trigger unintentional or hazardous adverse effects when taken in conjunction with Varubi. Your doctor could alter your treatment in the event that you use any of the following:

  • Pimozide;
  • Thioridazine.

Varubi is not permitted for use by anyone under 2 years old.

To ensure that this medication is appropriate for you, tell your doctor if you've previously had:

  • Liver disease
  • If you are using an anticoagulant (such as warfarin) and you've had regular "INR" or prothrombin time tests,

Consult a physician if you are breastfeeding or pregnant.This medication may alter fertility (your capacity to have kids) for a brief period.

How to take Varubi?

Consume Varubi tablets exactly as recommended by your physician. Follow the instructions on the prescription label and review all medication guides and instructions sheets.Varubi is typically administered on the first day of chemotherapy.Tablets can be taken either with or without food.

It is not recommended to use Varubi more than once in 14 days.You'll be provided with additional medicines to treat vomiting and nausea. Continue to take these medications for the duration of the time your doctor prescribes.Storage at room temperature is far from heat and moisture. Place each tablet in the foil-covered packaging until you're ready to use the medication.

Details on dosage

Usual Adult Dose for Nausea/Vomiting—Chemotherapy Induced:

Oral 180 mg, orally 2 hours prior to the beginning of chemotherapy on Day 1.
Parenteral 166.5 mg IV injection (over 30 minutes) at least 2 hours prior to the beginning of chemotherapy on Day 1.
Highly Emetogenic Cancer Chemotherapy (HEC):
Day 1: Dexamethasone 20 mg taken orally 30 min ahead of chemotherapy. 5-HT3 antagonist according to the treatment guidelines
Days 2 through 4 2 to 4: Dexamethasone 8 mg, taken orally, 2 times per day
Moderately Emetogenic Cancer Chemotherapy (MEC):
Day one: Dexamethasone 10 mg, taken orally for 30 minutes prior to starting chemotherapy. 5-HT3 antagonist according to the guidelines for treatment
Additional doses of 5-HT3 antagonists could be administered according to the manufacturer's guidelines and treatment.
The manufacturer's product information provides the correct dosage information for these medications.
This dose should be administered in the first week of chemotherapy and should be administered at not less than two-week intervals.
Use: In conjunction with other antiemetic drugs to prevent nausea and vomiting that is delayed with the first and repeat course of chemotherapy for cancer that is emetogenic, such as HEC

What happens if I miss the dose?

Consult your physician for guidance in case you fail to take your tablets at the right time prior to chemotherapy. Your dose timing is crucial to ensuring that this medication is efficient.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

At least one month after using Varubi, avoid taking any cold or cough medicine that contains the ingredient dextromethorphan. Consult your physician about the best way to cure a cough that is caused by an illness known as the commonly occurring cold.

Side effects of Varubi

See a doctor immediately. If you show symptoms that you are experiencing an allergic reaction, Varubi: hives, breathing problems, and swelling of your lips, face, or tongue.

Contact your doctor immediately. If you are suffering from:

  • Burning or pain during urination;
  • Red blood cell count is low (anemia); pale skin; unusual fatigue sensation of lightheadedness or sluggish or cold feet and hands;
  • Low white blood cells The gums are swollen, there are common sores in the mouth, painful skin sores, and flu or cold symptoms. Cough, trouble breathing.

Common Varubi side effects can include:

  • Low blood cell count;
  • Urination that is painful;
  • Mouth sores;
  • Hiccups;
  • Dizziness;
  • Stomach discomfort, indigestion, and lack of appetite.

This isn't a complete list of possible side effects, and other side effects could occur. Consult your physician for advice regarding medical adverse effects. Report any adverse reactions directly to the FDA at 1-800-FDA-1088.

Interaction with other drug

For a minimum of 28 days following the time you have used Varubi, it may affect other medications you're taking.It is sometimes not safe to take certain medications in combination. Certain drugs may affect the blood levels of other medications you are taking, which could cause more side effects or make the drugs less effective.

A variety of drugs may be incompatible with rolapitant, and certain medications should not be taken simultaneously. Inform your doctor about all the medications you currently take and all medicines you begin or stop taking. This includes prescription and over-the-counter medications, vitamins, and herbal supplements. The interactions between these products are not mentioned here.



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