The Web Health


Invokamet XR

Generic name: Canagliflozin and Metformin [KAN-a-gli-FLOE-zin-and-met-FOR-min]
Brand names: Invokamet and Invokamet XR.
Classification of drugs: Antidiabetic combinations

What is Invokamet XR?

Invokamet XR is a combination medicine that works in conjunction with exercise and diet to help improve blood sugar control for adult patients with type 2 diabetes mellitus. Invokamet XR can also be used to decrease the chance of dying from stroke, heart attack, or heart failure among adults suffering from type 2 diabetes who suffer from heart disease.

Invokamet XR is also utilized to decrease the risk of kidney disease, hospitalization, or death due to heart issues in adult patients who also suffer from kidney issues caused by type 2 diabetes. Invokamet XR cannot be used to treat type 1 diabetes. Invokamet XR can be used for other purposes that are not mentioned in this guide.

Side effects of Invokamet XR

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergic reaction, such as difficulty breathing, hives, or swelling of your lips, face, and tongue, You should seek medical attention promptly if you are experiencing symptoms of a genital illness (penis or vagina): burning, itching, and odor; bleeding tenderness; pain; swelling or redness of the rectal or genital region; fever; not feeling well. The symptoms could worsen rapidly. Mild signs of lactic acidosis can get worse as time passes, and this disease can become fatal. Stop taking this medication and consult your physician immediately if you experience unusual muscular discomfort, breathing problems, stomach pains, vomiting, dizziness, an irregular heartbeat, a cold, or are extremely fatigued or weak.

Invokamet XR may cause serious side effects. Consult your doctor immediately in the event that you experience:

  • New pain and tenderness new pain, tenderness, ulcers, sores, or infections that affect your feet or legs;
  • Minimal or no urination
  • An euphoric feeling, similar to passing out;
  • High potassium level; nausea and weakness; tingling sensations; chest pain; and irregular heartbeats. Muscle weakness
  • Ketoacidosis (too much acid in the blood): nausea, vomiting, nausea, confusion, unusual tiredness, difficulty breathing,
  • Indications of symptoms of a bladder indicate bladder disease—pain or burning sensation when you urinate, urine that appears cloudy, pain or discomfort in the pelvis or in the back.

Adults who are older are more likely to be dehydrated or suffer from kidney problems when taking this medication. It is possible to fracture a bone when you take this medication. Consult your doctor on ways to minimize the possibility of fractures.

Common adverse effects of InvokametXR could include:

  • Urinating more frequently than usual
  • Headache,
  • Weakness;
  • Gas,
  • Stomach pain,
  • Indigestion;
  • Nausea,
  • Vomiting,
  • Diarrhea.

This is not a comprehensive list of all the side effects. Other side effects could occur. Consult your physician to seek medical advice on the effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


You shouldn't take Invokamet XR if you have severe kidney disease or ketoacidosis. Canagliflozin can trigger serious infections of the vagina or penis. Get medical help immediately if you experience burns, itching, odor, discharge, pain or swelling, redness, tenderness of the rectal or genital region, fever, or are not feeling well.

It is possible to suffer from an illness called lactic acidosis. This is an extremely dangerous accumulation of the acid lactate inside your blood. Contact your physician or seek urgent medical attention in the event of strange muscle pains, difficulty breathing, dizziness, stomach pain, feeling cold, or feeling fatigued or weak.

Prior to use this drug

This medicine is for you if you're allergic to canagliflozin or metformin or suffer from:

  • Severe kidney disease
  • Ketoacidosis (call your doctor to seek treatment).

If you require any type of x-ray or CT scan that uses the injection of a dye into the veins of your body, you may require a temporary stoppage of Invokamet XR.

Canagliflozin could increase your chance of having your lower leg amputated, particularly if you've previously had a foot ulcer, amputation, or a heart condition with circulation issues and a nerve injury.

Inform your doctor if you have ever suffered from:

  • Heart issues;
  • A diabetic foot ulcer or amputation
  • Issues with circulation or nerves in your feet or legs;
  • Kidney or liver disease;
  • Vitamin B12 and calcium levels in your blood are low.
  • Bladder infections or other urinary issues;
  • A pancreas-related disorder or an operation;
  • A change in your diet; or
  • If you are following an eating plan that is low in salt,

It is possible to suffer from the condition known as lactic acidosis. It is an extremely dangerous accumulation of lactic acid in your blood. It's more likely if you suffer from another medical condition, a serious infection, persistent alcoholism, or are older than 65. Talk to your doctor regarding your risk.

Talk to your doctor when you find yourself pregnant. Canagliflozin may harm the unborn if you are taking this medicine in your third or second trimester. Metformin could stimulate ovulation in women who are premenopausal and increase the chance of an unintended pregnancy. Discuss with your physician regarding your risks. It is not recommended to use this medicine while breastfeeding. Invokamet XR is not approved for use by anyone under the age of 18.

What should be avoided?

If you've taken a dose in the evening of metformin extended-release tablets, do not take your final dose in that evening prior to beginning the daily dose of Invokamet XR. Follow the instructions on the prescription label and study all medication guides or instruction sheets. The doctor might alter your dosage. Follow the medication exactly as prescribed. Suck your tablets with extended release in their entirety, but do not crush, chew, or break them. There is a possibility that you are suffering from insufficient levels of blood sugar (hypoglycemia) and feel extremely hungry and dizzy, as well as irritable and anxious. You may also feel confused, nervous, or even shaky. To cure hypoglycemia, take a snack or drink a rapid-acting source of sugar (fruit juice crackers, hard candy, hard candy raisins, or any sugar-free soda).

Your physician may recommend the use of a glucagon injection kit if you suffer from severe hypoglycemia. It is important that your family or friends are aware of the procedure to give you the injection in an emergency. Also, look out for symptoms of high blood sugar levels (hyperglycemia) like a rise in thirst or increased urination. The levels of blood sugar may be impacted by illness, stress, surgical procedures, exercise, alcohol consumption, or not eating meals. Consult your physician prior to making changes to your medication or dosage schedule.

Your doctor might suggest that you take additional vitamin B12. You should only take the amount of vitamin B12 prescribed by your doctor. Advised. Consult your physician if you are experiencing persistent diarrhea or vomiting or are sweating more than normal. You could easily get dehydrated when you take Invokamet XR, which can result in severely reduced blood pressure or a severe electrolyte imbalance.

If you require medical or surgical procedures, be sure to inform the doctor who sees patients that you're using Invokamet XR. It is possible that you will be required to stop taking this medication at least three days prior to an operation. Consult your physician about ways to regulate the blood sugar level during this period. Invokamet XR is only part of a treatment plan that could also include exercise, diet, controlling weight, blood sugar tests, and medical treatment. Follow the instructions of your physician precisely. Place tablets in the original container within the room at room temperature,  away from heat and moisture. Don't keep Invokamet XR tablets in a daily pill box for more than thirty days.

What happens if I miss the dose?

Do the medication (with food) immediately if you can, but do not skip any missed dosage if it's nearing the time to take the next dose. Don't take more than two doses at once.

What happens if I overdose?

Get medical attention immediately, contact emergency medical attention, or call the Poison Help line at 1-800-222-1222. There is a possibility that you are suffering from a severe drop in glucose levels (extreme weakness and nausea, tremors or nausea, confusion, sweating, trouble speaking, rapid heartbeats, or seizures).

What should be avoided?

Beware of drinking alcohol. It can lower blood sugar levels and increase the chances of lactic acidosis.

Interaction with other drugs

Inform your doctor about any other medications you take, particularly:

  • Digoxin (digitalis, lanoxin);
  • A diuretic, or "water pill";
  • Insulin or other diabetes medications for oral use
  • Rifampin
  • Ritonavir
  • Seizure medicine—phenobarbital and phenytoin.

This list isn't complete. Other medications could influence InvokametXR, including prescription and over-the-counter medicines, vitamins, and herbal products. The interactions of all drugs are included in this article.



Prescription only

Pregnancy & Lactation

CSA Schedule*
Related Drugs
Related Stories