What is Ubrogepant?
Ubrogepant is a tablet that is used for adults who suffer from migraines. It is not a remedy for migraines. It was endorsed by the FDA in the year 2019 after research found that, two hours after people took ubrogepant for the first time, they experienced less discomfort and less of the migraine symptoms that are most troublesome (e.g., nausea or light sensitivity, as well as the sensitivity to sound) in comparison with other patients taking a placebo (dummy pill). It belongs to the class of medications known as calcitonin gene-related peptide (CGRP) receptor antagonists. CGRP can be found in the nerve endings implicated in migraines and pain. Ubrogepant stops the CGRP protein from binding to nerve endings, which reduces migraine pain and symptoms.
What are the uses of Ubrogepant?
- Ubrogepant is a prescribed medicine that is used to treat acute cases of migraine attacks that are with or without aura in adults.
- It is not intended to stop migraine headaches.
- It is not clear whether this medicine can be used safely and effectively for children.
Who is not safe to take Ubrogepant?
Do not take ubrogepant when you are taking a medicine called a strong CYP3A4 inhibitor, like:
- Ketoconazole
- Clarithromycin
- Itraconazole
Talk to your doctor for advice if you're not certain whether you're having any problems with these drugs. Your doctor can inform you if it's safe to take ubrogepant in conjunction with other medications.
Similar/related drugs
Ubrelvy, Botox, Diclofenac, Celecoxib, Sumatriptan, Metoclopramide, and Reglan
What should be avoided?
Before you start taking ubrogepant, tell your physician about your medical conditions, especially the following:
- Have liver issues
- Are you suffering from kidney problems?
- You are expecting or planning to be pregnant. It isn't known whether ubrogepant can cause harm to your baby.
- If you are nursing or planning to, you plan to. It isn't known whether ubrogepant can be found in your breast milk.
Inform your doctor about every medication you take, such as prescription and over-the-counter supplements, as well as vitamins and herbal supplements. Read the interaction section below for specific medicines that can interact with ubrogepant.
How to take Ubrogepant?
Follow the exact instructions that your doctor or healthcare professional instructs on how to use it. You can take your Ubrogepant tablet either with or without food. The majority of patients can take a second tablet two hours after the first in the event of a need. Do not take a second tablet within 24 hours of having consumed grapefruit juice or grapefruit, or if you are taking medication that includes:
- Verapamil
- Cyclosporine
- Ciprofloxacin
- Fluconazole
- Fluvoxamine
It isn't known whether it is safe to use ubrogepant to treat more than eight migraine headaches within 30 days. It is important to note down the times you suffer from headaches as well as when you take ubrogepant to ensure you can inform your doctor about how the ubrogepant has been working for you. If you are taking excessive amounts of ubrogepant, contact your doctor or go to the closest hospital emergency room immediately.
Side effects of Ubrogepant
The most frequent negative side effects of ubrogepant are sleepiness and nausea.
There aren't all those possible adverse effects associated with this drug. Contact your doctor to get medical advice on adverse effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.
Interactions
Talk to your doctor about the medications you are taking, including prescription and non-prescription supplements such as vitamins and herbal supplements.
Inform your healthcare professional that you're taking any of these medications, since your doctor may have to alter the dosage of ubrogepant.
- Verapamil
- Cyosporine
- Ciprofloxacin
- Fluconazole
- fluvoxamine
- Phenytoin
- Barbiturates
- Rifampin
- John's Wort
- Quinidine
- Carvedilol
- Eltrombopag
- curcumin
They aren't all the drugs that may influence how ubrogepant performs. Your doctor can inform you if it's appropriate to take ubrogepant along with other medications.
