What is Sirolimus protein-bound?
Sirolimus protein-bound is used in adults to treat a specific type of perivascular ectoid cell tumour (pecoma). Sirolimus bound to proteins can be used in other ways not mentioned in this guide.
Side effects of Sirolimus protein-bound
If you experience any of the following signs and symptoms of an allergic reaction: hives, difficulty breathing or swelling of lips, face, tongue or throat. Please seek immediate medical assistance:
Sirolimus that is protein-bound can cause serious side effects. If you experience:
- Feeling short of breath, chest pain, dry cough,
- Any bleeding that won't stop, including nosebleeds, bleeding gums, and abnormal vaginal bleeds
- Low blood potassium—leg pain, constipation; increased thirst or urination; numbness, tingling or numbness, muscle weakness, or a limp feeling
- Signs of infection include fever, chills, and a sore throat. Body aches, unusual fatigue, loss of appetite or appetite, bruising, bleeding, or bruising
- Low blood cell counts can cause fever, chills, and fatigue, as well as mouth sores or skin sores. They may also result in easy bruising or bleeding, pale skin on the hands and feet, or a feeling of being light-headed.
Side effects of sirolimus bound to proteins may include:
- Blisters or ulcers on your lips, red or swollen gingiva, difficulty swallowing
- Fever, chills, and body aches
- Tiredness;
- Cough;
- Changed sense of taste
- Rash;
- Nausea, diarrhoea, vomiting;
- Swelling;
- Joint pain, muscle, bone,
- Loss of appetite and weight
There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.
Similar/related drugs
Fyarro
Warnings
Men and women who use sirolimus-protein-bound should both use birth controls in order to avoid pregnancy. Sirolimus can cause harm to an unborn child if either the mother or father are taking this medication.
Before you take this drug
If you have an allergy to sirolimus, other rapamycin-derived products, or albumin, then it is best not to use the protein-bound version.
Inform your physician of any of the following issues:
- Liver disease
- Diabetes;
- Breathing problems
- Bleeding problems
Women and men who use this medication should both use effective birth controls to prevent pregnancy. Sirolimus, which is protein-bound, can harm an unborn child if either the mother or father uses this medicine.
Continue to use birth control at least 12 weeks after your last dose. Inform your doctor immediately if you become pregnant. Before starting the treatment, you will need a negative pregnancy result. Sirolimus that is protein-bound can affect the fertility of men and women. This medicine can make it harder for either parent to get pregnant. Do not breastfeed for 2 weeks after taking this medication.
How to take Sirolimus protein-bound?
Read all the instructions or guides that come with your medication and follow the directions. Sometimes your doctor will change the dose.
A healthcare professional injects sirolimus-bound protein into a vein over a period of 30 minutes on the first and eighth days of each 21-day cycle. You will need to have your blood sugar checked regularly, and you may also need other medical tests.
Details on dosage
Adult dose for malignant perivascular epithelioid cell neoplasms:
Dosage: 100 mg/m2 IV over 30 minutes on Days 1 and 8 of each 21-day cycle.
Duration of treatment: until disease progression or unacceptable side-effects arise. Adults with locally advanced, unresectable, or metastatic malignant epithelial cell tumours (pecoma)
What happens if I miss the dose?
If you miss a dosage, call your doctor to get instructions.
What happens if I overdose?
In a medical setting, an overdose is treated immediately.
What should be avoided?
Avoid receiving "live" vaccinations. You may find that the vaccine does not work well when you use sirolimus. Live vaccines are measles (MMR), rubella, rotavirus (typhoid), yellow fever, varicella, typhoid (chickenpox), shingles (shingles), typhoid (HTML4_ cholera HTML4_)
Grapefruit can cause side effects when it interacts with protein-bound sirolimus. Avoid consuming grapefruit products.
Interaction with other drug
It is sometimes not safe to take certain medications at the same time. Using certain drugs together can cause side effects and/or reduce the effectiveness of other medications. Other medications, such as vitamins and herbal remedies, may also affect sirolimus. Inform your doctor of all the other medications you take.
