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Selexipag (oral/injection)

Generic name: selexipag (oral/injection) [se-LEX-i-page]
Names of brands: Uptravi, Uptravi Titration Pack
Dosage formats: intravenous injection (1800 mg) oral tablet (1000 mg; 1200 mcg; 1400 mg; 1200 mg; 1600 mg) 200 mcg; 800 mcg; 400 mg; 600 mcg; 800 mg)
Classification of drugs: agents for hypertension pulmonary

What is Selexipag?

Selexipag helps treat the condition of pulmonary arterial hypertension (PAH). Selexipag can help keep your condition from becoming worse and lower the chance of having to undergo hospitalization for PAH.

Selexipag is also employed for other purposes that are not covered in this guideline.

Side effects of Selexipag

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergic reaction, such as symptoms of hives, difficulty breathing, or swelling of your lips, face, or tongue,

Selexipag could cause serious adverse effects. Contact your doctor immediately if you suffer from:

  • Low red blood cells (anemia)--pale skin fatigue, lightheadedness or tiredness, cold hands and feet;
  • New lung issues: anxiety, pale skin, sweating, extreme shortness of breath, wheezing, gasping for breath, coughing, foamy mucus, chest pain, or a quick or irregular heart rate.

Common negative effects of selexipag could include:

  • Headache;
  • Jaw pain;
  • Muscle pain or discomfort in your arms or legs;
  • Joint pain;
  • Flushing (the warmth of redness or a tingly sensation);
  • Rash;
  • Anemia;
  • The feeling of nausea, vomiting, and loss of appetite diarrhea and
  • Redness, pain, or swelling after the selexipag injection was administered

This isn't a complete listing of all the side consequences. Other side effects could occur. Consult your physician for advice regarding medical adverse effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.

Warnings

Talk to your doctor about any other medications you're currently on. Certain medications should not be taken alongside selexipag.

Prior to use this drug

It is not recommended to use selexipag if you have an allergy to it.

Certain drugs shouldn't be used in conjunction with the use of selexipag. Your treatment regimen may be altered when you are also using:

  • Clopidogrel;
  • Gemfibrozil.

Talk to your doctor If you've ever been afflicted by:

  • A condition known as pulmonary Veno-occlusive disorder (narrowing of veins that transport blood from the lung into the heart)
  • The liver condition.

It is unknown whether selexipag can cause harm to an unborn baby. Inform your doctor if you are expecting or planning to be pregnant.Do not breastfeed.

How to take Selexipag oral?

Follow all the instructions on your prescription label, and go through all medication guides or instructions. The doctor might alter your dosage. Make sure you take the medicine exactly as prescribed.Selexipag oral is taken through the mouth.

Selexipag can be taken without or with food.Suck the tablet completely, and don't crush, chew, or break it.Selexipag injections are administered in an incision by a medical practitioner if you aren't able to take medication by mouth.Your condition may get worse if you stop using selexipag suddenly. Talk to your doctor prior to stopping the medication.Keep tablets in a cool, dry place, free of heat and moisture.

Details on dosage

Usual Adult Dose for Pulmonary Hypertension:

The first dose is 200 mg taken orally, twice daily.
Maintenance dose: Increase by increments of 200 mg every day every week until the dose that is the most well-tolerated
Dosage maximum: 1600 mg taken orally, twice daily.
Comment:
If the patient is at an amount that isn't well tolerated, lower it to a dose that is previously tolerated.
Use: In the treatment of hypertension of the pulmonary artery (PAH), to slow the development of the disease and lower the likelihood of hospitalization for PAH.

What happens if I miss the dose?

Take the medication as quickly as you can; however, do not miss your missed dose if the scheduled dose is due to be taken in less than six hours. Don't take two doses in one go.

If you have missed doses for three or more days, consult your physician before taking a dose. It is possible that you will need to retake the medication at the dose you were taking before.

What happens if I overdose?

In case of medical emergencies, seek urgent medical attention or seek assistance at the Poison Help Line at 1-800-222-1222.

What should be avoided?

Follow the doctor's advice regarding any restrictions on your food, drink, or any activity.

Interaction with other drugs

There are times when it's not recommended to take certain medicines simultaneously. Certain drugs may affect the blood levels of the other drugs that you are taking, which can create side effects or render the medication less effective.

Other medications may interact with the selexipag effect, including prescription and non-prescription medications, vitamins, and herbal products. Tell your doctor about any other medications you are taking.

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Prescription only

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