Sandostatin

What is Sandostatin?

Sandostatin is a human-made protein that is akin to a hormone that is found in our bodies known as somatostatin. Octreotide decreases a variety of components in the body, like insulin and the hormone glucagon (involved in the regulation of blood sugar), as well as growth hormone and other chemicals that influence digestion.Sandostatin can be used to treat acne.

Sandostatin can also be used to help reduce the frequency of flushing and the watery diarrhea caused by cancerous tumors (carcinoid syndrome) or vasoactive tumors. Intestinal tumors made of peptides (vipomas).

Warnings

Take Sandostatin as directed by your physician. Follow all the instructions on your prescription label and on the packaging. Inform your healthcare professionals about your medical ailments and allergies, as well as the medicines you are taking.

Before you take Sandostatin, inform your doctor that you suffer from gallbladder disease, diabetes, heart disease, high blood pressure, an irregular heart rhythm, thyroid issues such as pancreatitis, liver disease, or kidney disease.

You might be taught how to administer one at your own home. Do not inject Sandostatin yourself in case you don't fully comprehend how to administer the injection. Also, be sure to get rid of needles that are used for IV tubing, needles, and other equipment required to inject the drug. Make sure you follow the instructions to inject the exact kind of Sandostatin that your doctor is prescribing for you.

To ensure that Sandostatin has a positive effect on your health and does not have harmful adverse effects, your blood cells, kidney function, and liver function could require regular testing. Don't miss any subsequent appointments with your doctor to conduct urine or blood tests. Make an appointment with your doctor right away when you notice a severe side effect, such as bleeding or bruising, an irregular heartbeat, or severe discomfort in your stomach, which then spreads to your back.

Prior to use this drug

Sandostatin is not recommended if you are allergic to Octreotide.

To ensure that Sandostatin is safe for you, inform your doctor if you have previously had:

• Diabetes;
• Gallbladder disorder;
• Heart disease, excessive blood pressure, or heart rhythm disorder
• Thyroid problems;
• Pancreatitis;
• Liver disease liver disease
• Kidney disease (or those who are taking dialysis).

Inform your doctor if you are nursing or pregnant.

Sandostatin use can alter certain hormones, which can help you fall pregnant even if it was impossible to conceive prior to. Discuss with your physician about birth control options to prevent unwanted pregnancies.

Sandostatin is not permitted for use by anyone who is younger than

Similar/related drugs

Octreotide, bromocriptine, lanreotide, Somatuline Depot, Sandostatin LAR Depot, Parlodel

How to take Sandostatin?

Follow the exact dosage of Sandostatin as directed by your physician. Follow the instructions on the prescription label and go through all the medication guides or instructions. The doctor might alter your dosage.

Sandostatin injections are injected beneath the skin muscle or into the vein. The doctor will provide the first dose and guide you on how to make use of the drug on your own.Be sure to read and follow the instructions for use that come with your medication.

Make an injection only when you are able to administer it. Don't use any medicine that changes color or has particles. Consult your pharmacist about the latest medication.Your physician will tell you the best place on your body to inject Sandostatin. You should use a different spot every time you administer an injection. Make sure you don't inject in the same area twice in the same row.

You'll need to take regular medical tests.If you are in need of radiation treatment, you might need to stop taking Sandostatin for an indefinite period. Follow the instructions of your physician attentively.Unopened sandostatin within the original container inside the refrigerator. Keep away from the light. Avoid freezing.

Remove the ampul from the refrigerator and allow it to cool to room temperature before injecting the dose. Don't heat the ampul. Each ampul is meant for only one usage. It is discarded after just one usage, regardless of whether there is remaining medicine inside.

You can also keep the unopened amp at room temperature for up to 14 days. Discard the ampul when it is not used in 14 days.Use a needle or syringe just once, and then place them into the puncture proof "sharps" container. Make sure you follow local or state laws on how to dispose of the container. Make sure it is out of reach of pets and children.

Details on dosage

Usual Adult Dose for Carcinoid Tumor:

Initial dosage: 100–600 mg per day, administered intravenously or subcutaneously with 2–4 doses divided into four.
Comments:
The daily average dose was 450 mcg. The mean daily dose is 300 mg.
Benefits were observed in doses of 50 mcg up to 1500 mcg daily.
Experimentation with doses higher than 500 mg per day is not recommended.
A Long-Acting Depot Formulation (Establish tolerance to short-acting formulation for no less than two weeks prior to making use of the formulation):
Initial dosage: 20 mg IM (intragluteal) at intervals of 4 weeks for a period of 2 months; then keep taking doses of octreotide as usual for at least two weeks (at the same dose that the patient was taking prior to the change).
Within 2 months
If symptoms are under control, you can reduce the dose to 10 mg once every 4 weeks.
If symptoms aren't adequately managed, increase the dosage to 30 mg every 4 weeks.
Maximum dose: 30 mg every 4 weeks
Comments:
Failure to maintain the dosage of the regular octreotide and switching to the long-acting formulation can cause a relapse. Some patients may require 3–4 weeks of simultaneous doses.
Treatment for the symptoms of patients suffering from metastatic carcinoid tumors It can reduce or stop the extreme flushing and diarrhea episodes that are associated with the disease.

Dose for Peptide Tumor:

Initial dosage: 200–300 mg per day, administered intravenously or subcutaneously between 2 and 4 equal doses
Maintenance dose: 150–800 mg/day
Doses of more than 450 mg per day are rarely necessary.
A Long-Acting Depot Formula (Establish tolerance with the short-acting formulation for at most 2 weeks prior to making use of this formula):
Initial dosage: 20 mg IM (intragluteal) at intervals of 4 weeks for 2 months. Continue by taking a dose of octreotide regularly for a minimum of 2 weeks (at the same dose that the patient was taking prior to the change).
Two months later:
If symptoms are under control, you can reduce the dose to 10 mg every 4 weeks.
If symptoms are not properly managed, increase the dosage to 30 mg every 4 weeks.
Comments:
Adjust the dose to achieve therapeutic effect.
Use: long-term treatment for the severe watery diarrhea that is associated with Vasoactive Intestinal Peptide (VIP) tumors that secrete it.

Dose for Acromegaly:

Initial dose: 50 mg in IV or subcutaneously 3 times per day.
Dose for maintenance: usually 100 mg, three times per day.
Maximum dose: 500 mcg, 3 times a day.
Comments:
Starting with a low dosage can allow patients to adjust to adverse gastrointestinal events.
Use the IGF-1 (somatomedin C) levels every two weeks as a guide for the rate of titration.
Multiple levels of growth hormone between 0 and 8 hours after the dose could allow for faster dosage adjustment.
Doses of more than 300 mg per day are not likely to provide any additional biochemical benefit.
The Long-Acting Depot formulation (establish tolerance with the short-acting product for a minimum of 2 weeks prior to making use of this formula):
Initial dosage: 20 mg IM (intragluteal) in 4-week intervals for 3 months
Three months later:
If GH is 1 ng/ml or below, the IGF-1 level is normal, and symptoms are controlled clinically at 10 mg intramuscularly every 4 weeks.
If the GH level is 2.5 ng/ml or less, Clinical signs are controlled at 20 mg, administered intramuscularly every 4 weeks.
If GH is greater than 2.5 ng/ml or clinical symptoms are uncontrolled, 30 mg IM, every four weeks.
If IGF-1, GH, or symptoms aren't adequately treated with 30 mg of GH, you may increase the dosage up to 40 mg IM every 4 weeks.
Maximum dose: 40 mg, every 4 weeks
Comments:
The goal is to have growing hormone (GH) levels below 5 ng/ml. IGF-1 levels below 1.9 U/ml (male) or 2.2 U/ml (female)
If increased doses do not provide additional benefit, reduce the dose.
Check growth hormone, or IGF-1, levels every six months.
For patients who have had radiation therapy, stop the medication every year for approximately 4 weeks (8 weeks for formulations with a long-acting effect) to evaluate the disease's activity, and if the growth hormone or IGF-1 levels rise and symptoms persist, presumptive treatment.
Use: To decrease the levels in the blood of growth hormone as well as IGF-1 (somatomedin C) in acromegaly patients who have not had a good response or can't be treated surgically or with radiotherapy.

What happens if I miss the dose?

Contact your doctor for advice when you have missed a dose.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact for help at the Poison Helpline at 1-800-222-1222.

Overdose symptoms can include severe stomach pain or diarrhea, weight loss, and tingling or warmth. Chills or numbness, unrelated muscle pain and weakness, fainting, a weak pulse, or slow breathing (breathing could be stopped).

What should be avoided?

Follow your doctor's advice regarding any restrictions on your food, drink, or any activity.

Side effects of Sandostatin

See a doctor immediately. If you show symptoms that you are experiencing an allergic reaction due to Sandostatin, such as hives, breathing difficulties, and swelling of your lips, face, and tongue,

Contact your doctor immediately if you are suffering from:

• Extremely constipation;
• Heartbeats that are irregular or slow
• Symptoms of gallstones include chills, fever, nausea, vomiting, and intense discomfort in your stomach, which then spreads to your lower dark urine, black stool, and jaundice (yellowing of the eyes or skin);
• Blood sugar levels are high, increasing thirst, more frequent urination, the mouth is dry, and there's a fruity smell.
• Lower blood sugar low blood sugar, headache or thirst, sweating, irritability, anxiety, fast heart rate, and feeling tense or shaky.
• Thyroid that is active Extreme tiredness, dry skin joints, stiffness or joint pain, muscular pain or weakness, a hoarse voice, and feeling less sensitive to temperatures that are cold Weight growth.

Common side effects of sandostatin include:

• Gallstones;
• Nausea, vomiting, diarrhea, stomach pain, gas;
• Pain, back pain,
• Dizziness, tiredness.

It's not a comprehensive list of the possible consequences, but other reactions could be experienced. Ask your doctor medical advice regarding adverse reactions. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drugs

Inform your doctor about your other medications, including:

• Bromocriptine (Cycloset, Parlodel);
• Cyclosporine;
• Insulin, oral diabetes medicine,
• Heart or blood pressure medications

This list isn't comprehensive. Other medications can interact with octreotide. These include prescription as well as over-the counter medications, vitamins and natural products. Some interactions with drugs are not listed here. Are included here.