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ReliOn/NovoLIN N

Generic name: insulin isophane [IN-soo-lin-EYE-soe-fane]

Brand names: HumuLIN N, HumuLIN N KwikPen, NovoLIN N, ReliOn/NovoLIN N
Drug class: insulin

What is ReliOn/NovoLIN N?

Insulin works by lowering glucose levels in the blood. ReliOn/The intermediate-acting insulin NovoLIN N starts working within 2 to 4 hours after injection. It peaks between 4 and 12 hours, then continues to work for 12 to 18 hours.ReliOn/NovoLIN® N helps to control blood sugar levels in children and adults with type 2 diabetes.ReliOn/NovoLIN may be used in other ways not mentioned in this guide.

Side effects of ReliOn/NovoLIN N

If you experience any of the following symptoms, you should seek emergency medical attention: swelling or redness where the injection was administered; itchiness on your skin; a rash all over your body; difficulty breathing; chest pain; feeling as if you may pass out; or swelling around your throat or tongue.

ReliOn/NovoLIN N may cause serious side effects. Contact your doctor immediately if:

  • Fluid retention: weight gain, swelling of the hands or feet, or feeling short-breathing;
  • Low sodium—leg cramps, constipation, irregular heartbeats, increased thirst, urination or numbness, muscle weakness, or a limp feeling.

Relion/novolin may cause the following side effects:

  • Low blood sugar
  • Weight gain and swelling of the hands or feet
  • Mild rash;
  • The skin may become thicker or hollower where the medication was injected.

There may be other side effects. Call your doctor for medical advice about side effects. To report adverse effects, you can contact the FDA at 1-800-FDA-1088.

Similar/related drugs

Ozempic, Mounjaro, Metformin, Trulicity, Lantus, Victoza, and Tresiba


ReliOn/NovoLIN should not be used if you have a low blood sugar episode.Do not share an injection pen, syringe, or syringe, even if it has been changed.

Before you take this drug

ReliOn/NovoLIN should not be used if the user is allergic to it or has an episode of hypoglycemia.Do not give ReliOn or Novoline to a child unless a doctor has prescribed it.

Inform your doctor if you experience any of these symptoms:

  • Liver or kidney disease
  • Low potassium levels in the blood (hypokalemia)

Inform your doctor if, in addition to insulin, you are taking pioglitazone and rosiglitazone. These medications may be combined with glimepiride and metformin. You may be at greater risk for serious heart problems if you take certain diabetes medications while using insulin.Inform your doctor if you are pregnant or nursing.If you're pregnant or plan to become pregnant, follow your doctor's advice about insulin.

How to take ReliOn/NovoLIN N?

Read all instructions or guides that come with your medication and follow all directions. Follow the directions on the label.ReliOn/NovoLIN N can be injected into the skin. You can learn how to use the medication properly by yourself from a healthcare provider.Do not mix ReliOn/NovoLIN with insulin pumps or inject into veins or muscles.ReliOn or NovoLIN should not be injected into skin that has been damaged, bruised, or pitted.Please read and follow all instructions for use that come with your medication. Ask your pharmacist or doctor if you don't understand.ReliOn/NovoLIN N will look cloudy when mixed. If the mixture is clear or contains particles, do not use it. For new medicines, call your pharmacist.You will be shown by your care provider where to inject ReligiOn or Novoline. Each time, use a new location. Do not use the same injection site twice in a row.Use only the ReliOn/NovoLIN-supplied injection pen. Attach a fresh needle each time. Don't transfer insulin from the pen to a syringe.Do not share an injection pen, syringe, or other device with anyone else. This is true even if you have changed the needle. It can spread infections and diseases from person to person.

If you have hypoglycemia, you may feel very hungry or dizzy. You might also be confused, anxious, irritable, or confused. If you want to treat hypoglycemia quickly, consume or drink something that will provide sugar quickly (such as fruit juice, hard candies, crackers, or raisins).In the event of severe hypoglycemia, your doctor may prescribe a glucagon injectable kit. Make sure that your family and friends are familiar with how to administer this injection in case of an emergency.Watch for signs such as increased thirst and urination.Stress, illness, surgery, or alcohol consumption can affect blood sugar levels. Consult your doctor before changing the dose or schedule of your medication.ReliOn/NovoLIN N may be part of a comprehensive treatment program that includes diet, exercise, and weight control. Blood sugar testing is also recommended, as is special medical care. Please follow your doctor's advice.This medicine should be kept in the original container, away from heat and sunlight. You should not transfer insulin from the vial to a syringe before you are ready for an injection. Store insulin away from the cooling element of a fridge. Do not use any frozen insulin.

Store unopened (not used). ReliOn/NovoLIN n:

  • Use within the expiration date.
  • Keep your medication at room temperature, and use it within the specified number of days in the instructions for use that came with the medicine.


  • Keep your medication in the refrigerator or at room temperature as instructed in the instructions for use that came with it. Injectors that are still in use should not be refrigerated.
  • ReliOn/NovoLIN is stable only for a limited number of days. Toss away any medicine that has not been used in this time frame. Keep your medicines in accordance with the instructions provided.

Only use a needle or syringe once, and then store them in a "sharps container" that is puncture-proof. Be sure to follow local or state laws on how to properly dispose of the container. Keep the container out of reach of pets and children.Wear or carry medical identification in case of an emergency to alert others that you have diabetes.

What happens if I miss the dose?

If you are almost due for your next dose, skip the missed dose. Never take two doses of the same medicine at once.Refill your prescription before you run out.

What happens if I overdose?

Call the Poison Help Line at 1-800-222-1222 or seek emergency medical attention. An insulin overdose can lead to life-threatening hypoglycemia. The symptoms include drowsiness and confusion.

What should be avoided?

Insulin can cause low sugar levels. ReliOn/NovoLIN can cause low blood sugar. Avoid driving or operating machines until you are sure of how they will affect you.Check the label of your medicine before you inject insulin to avoid medication mistakes. Some brands are interchangeable with others, such as insulin isophane or syringes.Avoid alcohol. Alcohol can cause low sugar levels and interfere with diabetes treatment.

Interaction with other drug

ReliOn/NovoLIN N might not work as effectively when used with other medications. It includes over-the-counter and prescription medicines, vitamins, and herbal products. You may also experience fewer hypoglycemic symptoms when taking certain drugs, making it more difficult to detect low blood sugar. This list does not include all possible interactions. Inform your doctor of all medications you begin or stop taking.