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Generic Name: Ranolazine [ra-NOE-la-zeen]
The Brand Names are Asprushya Sprinkle and Ranexa.
Dosage Formats: Oral granule, extended release (1000 mg/500 mg), or oral tablet extended release (1000 mg/500 mg).
Drug Class: Antianginal agents

What is Ranolazine?

Ranolazine is a medication used by older adults for the treatment of persistent angina (chest pain). It is not recommended to use it in the event of an acute (emergency) attack of angina.

Ranolazine can also be used for reasons not mentioned in this medication guide.

Side effects of Ranolazine

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergic reaction, such as difficulty breathing, hives, and swelling of your lips, face, and tongue,

Ranolazine may cause serious side effects. Consult your physician immediately in the event of:

  • A feeling of lightheadedness;
  • Heartbeats that are fast or rapid, your chest fluttering, shortness of breath, and an abrupt dizziness (like you're about to pass out)
  • Kidney issues: swelling, less urination, and feeling tired or exhausted.

Common negative side effects of the drug ranolazine include:

  • Nausea, constipation;
  • Headache
  • Dizziness.

This is not a comprehensive list of possible side effects, and other side effects could occur. Consult your physician for advice regarding medical adverse effects. You can report any symptoms to the FDA at 1-800-FDA-1088.


It is not recommended to take ranolazine when you suffer from the condition of cirrhosis, which affects the liver.

Inform your doctor about all other medications. Certain medications should not be taken with ranolazine.

Before you Take this Drug

It is not recommended to take ranolazine if you are sensitive to the substance or suffer from:

  • The liver has cirrhosis.

Certain drugs shouldn't be taken in conjunction with ranolazine. Your treatment plan may be altered if you make use of:

  • Clarithromycin;
  • Nefazodone;
  • St. John's wort;
  • Antifungal medicine (itraconazole, ketoconazole);
  • HIV or AIDS treatment: indinavir, lopinavir/ritonavir, indinavir, ritonavir, and saquina;
  • Seizure medicine—carbamazepine, phenobarbital, or phenytoin;
  • Tuberculosis medicine—rifabutin, rifampin, and rifapentine.

Speak to your doctor if you have ever suffered from:

  • The long QT disorder (in either you or a member of your family);
  • Liver disease
  • Kidney disease.

See your doctor if you are breastfeeding or expecting.

How to Take Ranolazine?

Follow the directions on the label of your prescription and study all medication guides or instruction sheets. Your doctor may alter the dosage. Follow the medication precisely as directed.You can consume ranolazine tablets with or without eating.Take a look inside the ranolazine powder and mix the medicine with a teaspoon of soft food like yogurt or applesauce. Drink the mixture immediately without chewing or crushing.

The granules of ranolazine can also be given via an infusion tube. Talk to your pharmacist or doctor if you don't understand the directions.Take the tablet in one swallow and make sure you don't crush, chew, or break it.Chronic angina is usually treated with an array of drugs. Do not alter your dosage or frequency of dosing without your physician's guidance.Consult your doctor if symptoms don't improve or if they become worse.You might need a medical test to assess kidney and heart function.Keep the items at room temperature and free of heat and moisture.

Details on Dosage

Usual Adult Dose for Angina Pectoris:

500 mg taken orally twice per day. Eventually, increase it to 1000 mg every day, twice per day if needed.
Maximum dosage of 1000 mg taken orally, twice daily
Use: Treatment for chronic angina

What Happens if I Miss the Dose?

Do not miss the missed dose, and take the next dose at the normal time. Don't take two doses at the same time.

What Happens If I Overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

The symptoms of an overdose can include vomiting, nausea, vomiting, a feeling of tingling or numbness, decreased blood pressure, dizziness, irregular heartbeats, difficulty speaking, hallucinations, double vision, anxiety, shaking that is not controlled, or fainting.

What Should be Avoided?

Avoid driving and other hazardous activities until you understand the effects of ranolazine. Your reaction could be affected.Beware of drinking alcohol. Consuming alcohol together with ranolazine granules may cause negative side effects.

Grapefruit can interact with ranolazine and cause unwelcome negative side effects. Do not use products made from grapefruit.

Interaction with Other Drugs

Inform your doctor about all the medications you take. Numerous drugs may affect ranolazine. These include:

  • Any other medication to treat any other heart-related disease;
  • As an antimicrobial or antifungal medicine.
  • Oral diabetes medicine;
  • Medication to avoid organ transplant rejection;
  • Medicine to treat mental illness
  • Medicines to prevent or treat vomiting and nausea due to radiation or chemotherapy.

The list below isn't exhaustive, and a variety of other medications could influence ranolazine. This includes prescription and over-the-counter medications, vitamins, and herbal supplements. There are many possible interactions between drugs that are included here.