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Generic name: diphtheria, pertussis acellular, polio, tetanus vaccine [dif-THEER-ee-a, per-TUS-is-a-SEL-yoo-lar, POE-lee-oh, TET-a-nus]
Names of brands: Kinrix and Quadracel
The class of drugs: vaccine combinations

What is Quadracel?

Diphtheria, pertussis acellular, polio, and tetanus are serious infections caused by viruses or bacteria. The disease can cause breathing problems, paralysis, cardiac failure, or even death.Pertussis (whooping cough) can cause long-lasting, severe episodes that cause coughing that may interfere with drinking, eating, or breathing. Pertussis can cause respiratory illness, seizures, brain damage, and death.

Polio can affect the nervous system of central origin as well as the spinal cord, leading to muscle insufficiency and paralysis. It can cause death in the event that it disables muscles that aid in breathing.

Tetanus (lockjaw) is a painful muscle tightening that can cause "locking" of the jaw, which means that the patient is unable to open their mouth, swallow, or breathe. Tetanus could cause death. Pertussis, diphtheria, and polio can be transmitted from one person to another. Tetanus is introduced into the body via an injury or cut. This vaccine is intended to prevent the spread of these diseases among children ages 4 and 6 (before their 7th birthday) who have had prior vaccinations with DTaP as well as an IPV series. The vaccine can help your child's body build immunity against these diseases. However, it does not treat an active disease that your child is already suffering from. Like all vaccines that are available, the diphtheria, pertussis acellular, polio, and tetanus vaccines may not be able to protect against disease for every person.

Side effects of this vaccine

See a doctor immediately. If your child shows symptoms warning of an allergic reaction, such as hives, difficulty breathing, or swelling of your lips, tongue, throat, or face,

Your child shouldn't receive an additional vaccine if they suffer a life-threatening allergic reaction within 24 hours of receiving the initial shot. Be aware of all the adverse effects your child may experience. If your child has an additional dose, inform your vaccination provider if the previous shot resulted in any adverse effects.

Infection with diphtheria, pertussis, polio, or tetanus poses a greater risk for the health of your kid than getting this vaccine. Like all medications, the vaccine could cause negative side effects; however, the chance of serious adverse side effects is minimal.

Contact your child's physician immediately if your child is suffering from:

  • Crying for more than an hour;
  • Extremely extreme fever extremely high fever
  • A feeling of lightheadedness, as if you're about to pass out.

It is possible to treat pain or fever with a pain reliever that is available over the counter, like acetaminophen (Tylenol) as well as ibuprofen (Motrin, Advil, and many others). Follow the label's directions or the instructions of your vaccination provider.

It is particularly important to prevent fever from arising when you suffer from seizures, such as epilepsy.

Common adverse effects of Quadracel could include:

  • Drowsiness;
  • Headache, muscle pain;
  • Lack of appetite or
  • Redness, pain, or swelling in the area where the shot was administered

This is not a comprehensive list of all the side effects. Other side effects could occur. Contact your child's doctor for advice regarding medical adverse effects. You can report any adverse effects directly to health officials at the US Department of Health and Human Services by calling 1-800-822-7967.


Being infected by diphtheria, pertussis, or polio, as well as tetanus, poses more dangers for your child's health than getting the vaccine.

Before you start taking this medicine

Your child should not get this vaccine if they are victim of:

  • An allergy that is a life-threatening reaction to vaccines containing diphtheria, pertussis, tetanus, or polio;
  • A history of diminished consciousness, seizures, coma, or delusions within 7 days of receiving the pertussis vaccine
  • A progressive or untreated nerve system disorder or brain disease (such as infantile spasms or epilepsy that is not controlled).

Your child might not be able to get this vaccine if they have had an infection caused by pertussis that includes:

  • Within 48 hours following the vaccination: a very high temperature (over 104°F) or excessive crying for more than 3 hours; fainting or going into shock in the first 48 hours after vaccination; or
  • Within 3 days of the vaccination, a seizure

Inform the vaccine provider if your child has received:

  • Seizures;
  • Treatment or radiation;
  • An insufficient immune system (caused by illness or taking certain medicines);
  • Guillain-barre syndrome in the first six weeks of receiving the tetanus vaccination; or
  • An allergy to latex rubber.

The child may still get vaccinations even if he or she is suffering from a mild cold. If you suspect an illness that is more serious, such as a fever or other type of illness, wait until your child recovers before receiving the vaccine.

How to take this Vaccine?

This vaccine is given by injection (shot) into the muscle.

The vaccine is administered in the fifth dose of the sequence of DTaP immunizations as well as the fourth dose of the sequence of IPV immunizations. The shot is typically given to children who are at or above the age of 4 or who have not yet reached the age of seven.

The schedule for your child's booster could be different from the guidelines below. Follow the instructions of your child's doctor or the schedule suggested by the regional health center.

What happens if I miss a dose?

Consult your child's physician if your child misses the dose of boosters or if the child is behind schedule. The next dose must be administered when it is possible. There is no reason to re-start the process.

Make sure that your child is receiving all doses recommended in the DTaP and IPV series; otherwise, the child might not be completely protected from disease.

What happens if I overdose?

A high dose of this vaccine is not likely to occur.

Avoid this

Follow the vaccine provider's guidelines regarding any restrictions on food, drinks, or any activity.

Interaction with other drugs

Before you receive this vaccine, inform the vaccine provider about any other vaccines your child may have received.

Additionally, inform the doctor who administered the vaccine whether your child has recently been treated with drugs or other treatments that could weaken your immune system, for example:V

  • Steroid medicine;
  • Treatments for cancer treatments;
  • Medications to treat the symptoms of psoriasis, rheumatoid arthritis, or other conditions that are autoimmune treatments for autoimmune disorders such as
  • Medication to prevent or treat organ donation

In the event that your child is taking any of these medications, they might not be able to get the vaccine or have to wait until other treatments are completed.

This list isn't complete. Other drugs can influence this vaccine, such as medications that are prescribed and available over the counter, vitamins, and herbal supplements. There are many possible interactions between drugs that are listed here.