What is Qinlock?
Qinlock is an inhibitor of enzymes that inhibits the activity of protein kinases. Qinlock is a prescribed medicine that is used to treat stomach tumors and intestines, particularly in patients with advanced gastrointestinal cancer (GIST). Qinlock is intended for those who have had treatment with at least three other cancer medications.
Warnings
Qinlock could cause male fertility issues that can affect your capacity to have children. Consult your doctor if this is an issue for you. Qinlock and certain other medications can interact, which can cause adverse effects or impact the way ripretinib functions. Talk to your doctor about all medications you use, including prescription and non-prescription supplements such as vitamins and herbal supplements.
Follow the directions on your prescription label and in the package. Inform your health care providers about your medical issues, allergies, and all medications you take.
Before taking this medication
You might not be able to use Qinlock in the event that you suffer from untreated, uncontrolled, or untreated hypertension (high blood pressure).
To ensure Qinlock is suitable for you, inform your doctor if you have previously had:
- The skin issue known as palmar-plantar syndrome;
- High blood pressure
- Heart issues or
- If you've had surgery or are planning to have surgery.
Utilizing Qinlock could increase the chance of developing skin cancer. The skin might require a check-up during the time you take this medication. Talk to your doctor about any conditions of the skin to look out for. It is possible that you will need to take a pregnancy test that is negative prior to beginning this treatment.
Men and women who are taking this medication should utilize effective birth control to stop pregnancy. Ripretinib can harm an unborn baby if the father or mother is taking this drug.Make sure you are using effective birth control methods to avoid pregnancy while using this medication and at least for a week following your last dose. Contact your physician immediately if you notice a pregnancy during the time that one of the mothers or fathers is taking Qinlock. This medication can affect fertility (the ability to bear children) in males. But it is crucial to utilize birth control in order to stop pregnancy, as Ripretinib may harm the unborn baby. Don't breastfeed while taking this medication or for at least one week following the last dose.
How to take Qinlock?
You should take Qinlock exactly as directed by your physician. Follow the directions on the prescription label and go through all medication guides and instruction sheets. The doctor might change your dosage. Suck the tablet completely and make sure you don't crush, chew, or break it. The medicine should be taken every day, either with or without meals. If you have a stomach ache within a few minutes of taking Qinlock, don't take a second dose.Be patient until the next dose is scheduled to start taking the medicine once more. Your blood pressure needs to be monitored regularly. The function of your heart may also require a check.
If you require surgery, inform your surgeon that you're currently using this medicine. You might have to stop taking the medicine for a brief period. The treatment for cancer may be delayed or discontinued permanently when you experience certain adverse effects. Do not alter your dosage or cease taking Qinlock without consulting your doctor. Keep the tablets at room temperature, free of heat and moisture. Store the tablets in their original containers and the packaging or container of preservatives with moisture absorption.
Details on dosage
Usual Adult Dose for Gastrointestinal Stromal Tumor:
150 mg taken orally every day until disease progresses or in the case of unacceptable toxicity
Use: For patients who have advanced gastrointestinal stromal tumor (GIST) and have had prior treatment using three or more inhibitors of kinase, such as imatinib.
What happens if I miss a dose?
You should take the medicine as fast as you can. However, do not take any missed dose if you are more than eight hours late to take the dose. Don't take two doses at once.
What happens if I overdose?
Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.
Avoid this
Qinlock can make you sunburn more quickly. Avoid sun exposure or tanning beds. Protect yourself with protective clothes and apply sunblock (SPF 30 or more) while you're outdoors.
Side effects of Qinlock
Get immediate medical attention. Get medical attention immediately if you show symptoms of an allergy reaction. Qinlock: hives, breathing problems, or swelling of your lips, tongue, throat, or face.
Contact your doctor immediately if you are suffering from:
- Severe stomach pain, nausea, or vomiting;
- A severe headache, blurred vision, the pounding of your neck or in your ears;
- Blisters, pain, or a severe rash on the hand's palms or in the soles of your feet
- Heart-related issues fatigue and feeling sluggish and with swollen veins along the neck's sides, lower legs, or stomach;
- Low red blood cells (anemia): pale skin, unusual fatigue, feeling lightheaded or short of breath, cold feet and hands,
- Change in skin appearance, the appearance of a wart, a skin red or sore bump that is bleeding or doesn't heal, or alter the size or shade of the mole.
Common Qinlock side effects can include:
- Nausea, stomach pain, vomiting, nausea, vomiting, and loss of appetite
- Diarrhea, constipation;
- Tiredness;
- Muscle pain; or
- Hair loss, thinning hair, losing hair
This is not a comprehensive list of possible side effects, and other side effects could be present. Contact your doctor to seek medical advice on the effects. You can report any symptoms to the FDA at 1-800-FDA-1088.
Interaction with other drugs
It is sometimes not safe to take certain medicines together. Certain drugs may affect your blood levels and the other medications you are taking, which could create side effects or render the medication less effective. Inform your doctor about the other medicines you take, particularly blood pressure medication.
Other medications may be incompatible with ripretinib. This includes medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your physician about the medicines you are currently taking as well as any medications you are about to start or stop taking.
