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Generic name: vutrisiran
Dosage form: injection, for subcutaneous use
Drug class: Miscellaneous metabolic agents

What is Amvuttra?

Amvuttra is used to treat polyneuropathy (damage to multiple nerves throughout the body) in adults diagnosed with hereditary transthyretin-mediated amyloidosis (hATTR).Amvuttra can also be used for reasons not mentioned in this guideline.


Follow the directions on the medicine label and on the label of your package. Inform your healthcare professionals about your medical issues, allergies, and any medications you take.

Before you take this drug

Before taking Amvuttra, consult your doctor about any medical issues or allergies.It is unclear if Amvuttra can harm an unborn baby. Inform your doctor if you are expecting or plan to be pregnant.Breastfeeding while taking this medication is not advised.. Consult your physician about any potential risks.

How to take Amvuttra?

Amvuttra is administered by subcutaneous injection (under the skin) every 3 months.A doctor will administer this injection.Your doctor might suggest that you take vitamin A supplements during the time you're taking Amvuttra. Only take your vitamin A dosage as that your physician has recommended, and especially in case you are expecting. A vitamin A overdose can result in vision problems or cause other serious side effects.Contact your doctor immediately. If you are experiencing vision issues (especially at night), even if you're taking vitamin A,It is possible that you require regular medical tests. Even if you don't have symptoms, tests may aid your doctor in determining whether this medication is effective. It is also possible that you will require frequent eye examinations.

What happens if I miss the dose?

Contact your doctor for advice in the event that you don't make the appointment for the injection of Amvuttra.

What happens if I overdose?

Because Amvuttra is administered by a medical professional in a medical environment, an overdose is not likely to occur.

What should be avoided?

Follow your doctor's advice regarding any restrictions on your food, drink, or any activity.

Side effects of Amvuttra

See a doctor immediately. If you are experiencing symptoms or warning signs of an allergic response, such as difficulty breathing, hives, or swelling of your lips, face, or tongue,

Common adverse reactions to Amvuttra can be:

  • Stiffness of joints (arthralgia)
  • Breath shortness (dyspnea)
  • Diminished levels of vitamin a.

This list does not represent all possible side effects.Other side effects could occur. Consult your physician for advice regarding medical effects. Report any adverse side effects directly to the FDA by calling them at 1-800-FDA-1088.

Details on dosage

Usual Adult Dose for Amyloidogenic Transthyretin Amyloidosis:

25 mg is administered via subcutaneous injections every 3 months.Use: to treat polyneuropathy caused by hereditary transthyretin-mediated amyloidosis in adults.

Interaction with other drugs

Other medications may interact with vutrisiran, such as prescription and non-prescription supplements, vitamins, and herbal products. Inform your doctor about your current medications as well as any medications you are about to start or stop taking.




Prescription only

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