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Generic name: polatuzumab vedotin [POL-a-TOOZ-use-mab-ve-DOE-tin]
The class of drug: miscellaneous antineoplastics

What is Polivity?

Polivy is a treatment for B-cell lymphoma that is diffuse following at least two different treatment treatments that failed, did fail, or were stopped from working. Polivy is administered along with bentamustine (Bendeka, Treanda) and an anti-inflammatory drug that contains the drug rituximab (Rituxan). Polivy can also be employed for other purposes that are not covered in this guideline for medication.

Side effects of Polivy

See a doctor immediately. Get medical attention immediately if you notice symptoms that indicate an allergic reaction, such as symptoms of hives, difficulty breathing, or swelling of your lips, face, or tongue. Polivy could cause a severe cerebral infection that could lead to disabilities or even death. Contact your doctor immediately when you experience issues with your speech, thoughts, or vision, as well as muscle movement. The symptoms can begin slowly and then get worse. There are some side effects that can happen after the injection. Inform your doctor when you are feeling irritable, chills, itchy, lightheaded, wheezing, chest tightness, or breathing difficulties within the first 24 hours following the injection.

Polivy can result in severe adverse consequences. Contact your doctor immediately if you suffer from:

  • Bleeding or bruising (nosebleeds and bleeding gums);
  • Weakness in the muscles;
  • Cough with mucus and chest pain. Feeling short of breath.
  • Pale skin tone, pale skin, cold feet and hands sensation of lightheadedness;
  • Nerve issues: tingling, numbness, burning sensation, pain in your feet or hands and feet, as well as weakness and difficulty walking;
  • Indications of infection: symptoms of infection include fever, colds, and night sweats; mouth sores; coughing; swelling of the glands; shallow breathing; burning or pain whenever you go to the bathroom; weight loss;
  • Symptoms of symptoms of symptoms of shingles the symptoms of shingles include flu-like symptoms, tingling sensations, or a painful blistering of the rash on the body's side.
  • Issues with the liver: loss of appetite and gastric symptoms such as stomach pain (upper right side) and dark urine jaundice (yellowing of the eyes or skin) or
  • Signs of tumor cell breakdown include confusion, weakness, muscle cramps, nausea and vomiting as well as fast or slow heart rates, decreased urination rates and tingling sensations in your hands and feet or around the mouth.

Common adverse effects of polivy could include:

  • Fatigue, fever, cough, or other symptoms of infection
  • Nerve issues and
  • Diarrhea and loss of appetite.

This isn't a complete list of all the side effects. Others could happen. Consult your physician for advice regarding medical effects. You can report any symptoms to the FDA at 1-800-FDA-1088.


Polivy can affect the body's immune system. It can cause you to contract infections more frequently, including severe or fatal infections. Consult your physician if you suffer from chills, fever, coughs, or mouth sores, unusual bleeding or bruises, pain sensation when you pee, or have problems with your speech, thinking, or muscle movement.

Prior to use this drug

Inform your doctor if you were ever diagnosed with:

  • Liver disease or
  • nerve issues (neuropathy) on your feet and hands.

Polivy could cause harm to a baby who is not born as well as cause birth defects in the case that the father or mother is using it.

  • If you're female, you may need to pass a pregnancy test before beginning this treatment. Don't use the Polivy drug when you are expecting. Make sure you use the most effective contraception to avoid pregnancy while using this medicine and for at least three months following your last dose.
  • If you're male, use effective birth control when your partner can get pregnant. Use birth control for a minimum of five months after the last dose.
  • Contact your physician immediately. If you become pregnant during the time that both the mother and father are using Polivy,

The medicine can impact the fertility (ability to have kids) of males. But it is important to utilize birth control to stop pregnancy, as polivy may harm an unborn baby.

Don't breastfeed during the course of this medication and at least 2 months after the last dose.

How to take Polivy?

Polivy can be given in the form of an infusion into the vein. Your healthcare professional will offer the injection. Polivy is generally prescribed every 21 days alongside rituximab and bendamustine. Your physician will decide how long you will be treated with these drugs. You might also be prescribed additional medications to help you avoid severe side effects and allergic reactions or infections. Use these medicines when your physician prescribes them.

Polivy impacts the body's immune system. It is possible to contract infections more frequently, and even fatal or serious infections. Your blood must be tested frequently, and additional doses could be delayed based on the results.

What happens if I miss the dose?

Contact your doctor for advice in the event that you don't make an appointment to see your doctor about your policy.

What happens if I overdose?

Because polivy is administered by a medical specialist in a medical setting, there is no risk of an overdose occurring.

What should be avoided?

Follow the doctor's advice regarding any restrictions on your food, drink, or any activity.

Interaction with other drugs

There are times when it's not recommended to take certain medications simultaneously. Certain medications can alter the blood levels of other medications you are taking, which could cause more side effects or make the drugs less effective. Polivy could cause liver damage, particularly in conjunction with certain medications to treat tuberculosis, depression, infections, hormone replacement, a high level of cholesterol in your blood, heart issues, high blood pressure, seizures, and pain (including Tylenol, Advil, Motrin, and Aleve). Other medications can impact Polivy, including medications that are prescribed and available over the counter, vitamins, and herbal products. Discuss with your physician all the medicines you are currently taking and any medication you begin or stop taking.