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Generic name: patisiran [PAT-i-SIR-an]
Drug class: Miscellaneous metabolic agents

What is Onpattro?

Onpattro is a double-stranded small interfering ribonucleic acid (siRNA) that is designed as a lipid-based complex injection. Onpattro is a prescription medicine used to treat adults with polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR) (damage of multiple nerves throughout the body). Onpattro is administered via infusion intravenous (IV) injection.


Follow the directions on the medicine label and in the package. Be sure to inform your healthcare professionals about your medical issues, allergies, and all medications you use.

Before you take this drug

Before taking Onpattro, tell your doctor about any medical issues or allergies. Patisiran may harm an unborn baby. Inform your doctor if you are expecting or planning to be pregnant. If you're pregnant and you are a registered mother, your name could be included on an OB-GYN registry to track any effects of the drug on the child. It might not be safe to breastfeed while taking this medication. Consult your physician about any potential risks.

What is the Onpattro?

Onpattro is administered in the form of an infusion into the vein. Your healthcare professional will administer the injection every 3 weeks. The medication must be administered slowly, and infusions can take up to an hour to be completed. Contact your physician. If you experience any burning, pain, or swelling near the needle of your IV when Onpattro is injecting, You could be prescribed additional medications to keep you from having adverse side effects, as well as an adverse reaction to the infusion.

Your doctor might recommend that you take Vitamin A during your treatment with Onpattro. You should only take what your physician has recommended, particularly if you are expecting. A vitamin A overdose can result in vision problems and other serious side effects.

Consult your physician immediately in case you experience vision problems (especially at night) during the time you are taking Onpattro. Doses for Onpattro are determined by weight. Your dose needs may change if you gain or lose weight.

It is possible that you require regular medical tests. Even if there are no symptoms, tests can aid your doctor in determining whether this medication is effective. You might also require regular eye examinations.

Details on dosage

Usual Adult Dose for Amyloidogenic Transthyretin Amyloidosis:

Dosing is determined by the weight of the individual; any premedication is recommended at least 60 minutes prior to the beginning of the infusion.

Less than 100 kg: 0.3 mg/kg via IV infusions every 3 weeks
100 kg or more, 30 mg by IV infusions every 3 weeks

The initial infusion rate should be 1 mL/min for the initial 15 minutes. Then, it should increase to around 3 mL/min throughout the duration of the infusion. In instances of related reactions, the time of the infusion could be prolonged. Consult the advice of the physician for instructions on the infusion.

Premedication: Take a dose on the day of infusion at a minimum 60 minutes prior to the beginning of the infusion.
500 mg of acetaminophen taken orally
IV corticosteroid (e.g., dexamethasone 10 mg or similar)
IV H1 blocker (e.g., diphenhydramine 50 mg or equivalent)
IV H2 blocker (e.g., the ranitidine dosage of 50 mg or similar)

Prescriptions are needed to lower the chance of developing an infusion-related reaction (IRR).
If IV premedications aren't readily available or are not a good fit, oral equivalents can be prescribed.
If patients are tolerated by the infusion but are experiencing adverse reactions to the corticosteroid prescription, reduce the corticosteroid dosage to 2.5 mg increments, to the minimum dose of dexamethasone (5 mg) or the equivalent.
Some patients might require higher or more frequent dosages of one or two prescription medications to decrease the chance of IRRs.

Use: For the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis.

What happens if I miss the dose?

Contact your doctor for advice. If you do not make an appointment with your Onpattro,

What happens if I overdose?

Because Onpattro is administered by a health expert in a medical environment, it is highly unlikely for an overdose to occur.

What should be avoided?

Follow the doctor's advice regarding any limitations on foods, drinks, or activities.

Side effects of Onpattro

Take immediate medical attention. If you are experiencing symptoms of an allergic response to Onpattro, such as hives or breathing difficulties and swelling of your lips, face, or tongue,

There are some side effects that can happen during the course of the injection. Inform your physician whether you feel cold, nauseated, dizzy, faint, itchy, sweaty, chest tightness, headache or back pain, difficulty breathing, or swelling of your face.

Common Onpattro side effects may include:

  • Signs of a cold, like nasal stuffiness, sneezing, and a sore throat.

This is not a comprehensive list of possible side effects, and others could happen. Consult your physician for advice regarding medical adverse effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drug

Other medications are also a factor in the interaction with Onpattro, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your physician about your current medications as well as any medications you are about to start or stop taking.