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Generic name: acetaminophen, dextromethorphan, and phenylephrine [a-SEET-a-MIN-of-fen, DEX-troe-me-THOR-fan, and-FEN-il-EFF-rin]

Brand names: cold and flu Daytime Relief, Comtrex Cold and Cough, DayQuil Cold and Flu, Daytime Flu and Severe Cold and Cough Daytime Powder,… show all 27 brands
Class of drugs: Combinations for upper respiratory tracts

What is Daytime?

Acetaminophen relieves pain and reduces fever. Dextromethorphan suppresses coughing. It works by affecting the brain signals that cause the cough reflex. Phenylephrine shrinks the blood vessels in the nasal passages. This is due to dilated blood vessels. The combination drug Daytime treats headaches, bodyaches, coughs, stuffed-up noses, sinus congestion, allergies, and the flu. A cough caused by emphysema, asthma, or smoking cannot be treated during the day. This medication guide does not list all possible uses of daytime.

Side effects of Daytime

If you experience any of the following signs and symptoms of an allergy reaction: Hives, difficulty breathing or swelling to lips, face throat or tongue Acetaminophen can cause severe reactions in some people, even when they have never had a reaction before. Call your doctor immediately if the skin becomes red or you develop a rash. If blisters form and you peel them off, stop taking this medication.

The use of daylight can cause severe side effects. Call your doctor immediately if:

  • Chest pain with a fast, slow, or irregular heartbeat;
  • Feeling dizzy to the point that it seems possible you could lose consciousness;
  • Mood changes, confusion, hallucinations, seizure (convulsions);
  • Little or no urinating is acceptable.
  • If you experience nausea, upper abdominal pain, itching, or loss of appetite; or if your urine is dark or has a clay color; or if your stools are yellow or have a darker color; or if you suffer from jaundice, or a yellowing of the skin or of the eyes; or if there's bowel or bladder problems, then this could be causing these symptoms:
  • High blood pressure can be dangerous (headache, nausea, ringing in the ears, anxiety, and chest pain).

Daytime can cause the following side effects:

  • Dizziness, weakness, mild headache;
  • Diarrhea, upset stomach;
  • Dry mouth, throat, nose, or nostril
  • Feeling nervous, restless, or irritable;
  • Sleep problems (insomnia).

There may be other side effects. Call your physician immediately if experiencing side effects; report these to FDA at 1-800-FDA-1088 for advice or reporting purposes.


You should not take this medication if you've taken an MAO inhibitor in the last 14 days. You could experience a dangerous drug interaction. The MAO inhibitors are isocarboxazid linezolid, phenelzine, rasagiline, selegiline, and transylcypromine.

Don't take this medicine in excess. Overdosing on acetaminophen may cause liver damage or death. Acetaminophen can cause severe reactions to the skin in rare instances. If you notice skin redness, a rash, or blistering that causes peeling and blistering on your skin, then stop taking the medicine immediately and contact your doctor.

Before you take this drug

If you've taken a MAO inhibitor within the last 14 days, do not take this medication. It is possible that a dangerous drug interaction will occur. There are several MAO inhibitors, including isocarboxazid (linezolid), phenelzine (phenelzine), rasagiline (selegiline), and tranylcypromine. This medication should not be used if you have an allergy to dextromethorphan, phenylephrine, or acetaminophen.

If you are suffering from any other health conditions or symptoms, you should consult your doctor before taking this medication.

  • Alcoholism or liver disease;
  • High blood pressure, coronary heart disease
  • Chronic bronchitis, asthma, copd, coughing with mucus, or smoking
  • Diabetes;
  • Glaucoma;
  • Overactive thyroid
  • Epilepsy and other seizure disorders
  • Pheochromocytoma
  • Other urination issues or bladder obstruction.

There is no way to know if daylight can harm an unborn child. If you are pregnant, do not take this medication without consulting your doctor. Acetaminophen and dextromethorphan can pass through breast milk, which may be harmful to a baby who is nursing. Decongestants can also reduce breast milk production. If you're breastfeeding, do not take this medication without consulting your doctor. Phenylalanine can be found in cold medicines that are artificially sweetened. Check the label of your medication to determine if it contains phenylalanine if you suffer from phenylketonuria.

How to take Daytime?

Do not exceed the recommended dosage or duration. Use only the recommended dose. Do not exceed it. This medication is typically taken for only a few days until the symptoms disappear. Don't take this medicine in excess. Acetaminophen can cause liver damage or death if taken in excess. This medication should not be given to children younger than four years of age. Ask a doctor first before you give cough medicine or cold medicine to your child. Children as young as 4 years old can die from misuse. Do not use a normal table spoon to measure liquid medicines. Use a dose-measuring spoon, medicine cup, or medicine scoop. Ask your pharmacist for a dosage-measuring device if you don't have one. One packet should be dissolved in 4 ounces or more of water. Mix this powder and water together, then drink it all immediately. Avoid taking it for more than seven days. Tell your doctor or surgeon if this medication was taken within the last few days and if you are going to need medical testing or surgery. Keep away from heat and moisture. Liquid medicines should not be allowed to freeze.

What happens if I miss the dose?

You may not have a regular dosing regimen since daytime can be taken as needed. Take the missed dosage as soon as possible if you take this medication regularly. If your next dose is approaching, skip the missed dose. You should not take more medicine to compensate for a missed dose.

What happens if I overdose?

Call the Poison Help Line at 1-800-222-1222 or seek emergency medical care. Acetaminophen overdoses can lead to death. Loss of appetite, vomiting, abdominal pain, confusion, or weakness are the first symptoms of an overdose of acetaminophen. Other symptoms include dark urine and yellowing skin or whites of the eyes. The side effects of this guide may include some severe cases of overdose symptoms.

What should be avoided?

Before using any other medication for colds, allergies, pain, or insomnia, consult your doctor or pharmacist. Many combination medications contain acetaminophen, also known as APAP. Taking some products with each other can result in an overdose of acetaminophen. The medication can affect your ability to think or react. You should be careful when driving or doing anything else that requires alertness. Alcohol is not recommended. You may be at greater risk for liver damage if you take acetaminophen.

Interaction with other drug

There are other drugs that may interact with Daytime. These include prescription, over-the-counter, herbal, and other products. Inform your healthcare providers of all the medicines that you are currently taking and those you plan to start using.



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