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Generic name: Clobazam [KLOE-ba-zam]
Drug class: Benzodiazepine anticonvulsants

What is Onfi?

Onfi is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). It is believed that clobazam is able to increase the activity of neurotransmitters within the brain. Onfi is administered in conjunction with other medicines in order to manage seizures caused by Lennox-Gastaut syndrome, an extremely severe form of epilepsy that can cause difficulties with development and behavior. Onfi is intended for patients who are 2 years old or older. It isn't known whether this medication has been proven safe or effective for infants younger than 2 years of age.


Onfi can reduce or stop breathing, especially if you have recently taken an opioid or alcohol. Make sure the medication is stored in a location where other people are unable to access it. There are people who have thoughts of suicide when taking seizure medication. Talk to your doctor right away when you notice any sudden changes in your mood and behavior or if you have thoughts about suicide.

Do not stop taking Onfi without consulting your physician. You could experience more seizures or potentially life-threatening withdrawal symptoms if you quit using the medication abruptly after long-term usage. Certain withdrawal symptoms may last for 12 months or more.

Seek medical attention immediately when you stop using Onfi and experience symptoms like abnormal muscle movements, becoming more talkative or active, or having sudden and extreme changes in your mood or behavior such as hallucinations, confusion, seizures, or even thoughts of suicide.

Before you take this drug

You shouldn't use Onfi if you have an allergy to Clobazam.

To ensure that Onfi is safe for you, inform your physician if you've previously been:

  • Lung disease or breathing problems;
  • Depression, mood disorders, or suicidal ideas or behaviors;
  • A dependency on alcohol, drugs, or
  • Kidney or liver disease.

There are people who think about suicide when they are taking seizure medications. Be aware of any changes to your attitude or signs. Your caregivers or family members are also required to be on the lookout for abrupt changes in your behavior.

If you take Onfi during pregnancy, your baby may be born with withdrawal symptoms that could be life-threatening and could require medical attention for a period of time.

Do not take or stop medication for seizures during pregnancy without a physician's guidance. Clobazam may harm the unborn baby; however, experiencing a seizure during pregnancy can be harmful to both mom and child. In the long run, preventing seizures can outweigh these dangers. Talk to your doctor as soon as you discover that you are pregnant. There could be other seizure medication options that are more secure to use during pregnancy.

Onfi can reduce hormonal birth control efficiency with methods such as birth control pills, injectables, implanted skin patches, and vaginal rings. Make sure you have a backup birth control device to stop pregnancy: a diaphragm, a condom, a cervical cap, and a contraceptive sponge. Continue using birth control for a minimum of 28 days following the previous dose of Onfi.If you're nursing, consult your doctor if there is an increase in drowsiness or problems with feeding the baby who is nursing. Onfi is not endorsed to be used by anyone less than 2 years old.

Similar/related drugs

Banzel, Epidiolex, Clonazepam, Lamotrigine, Topiramate, Lamictal, and Klonopin

How to take Onfi?

You should take Onfi exactly as directed by your physician. Follow the directions on the prescription label, and make sure you read all prescription guides or instructions sheets. Don't make use of Onfi in larger quantities or for a longer period than what is prescribed. Talk to your doctor if you have a strong urge to take more medication.

Don't share this medicine with anyone else, especially those who have an addiction history. A faulty use can lead to addiction, overdose, or death. Make sure the medicine is kept in a place away from the reach of others who might need it. Giving away or selling this medicine is against the law. You can take Onfi either with food or without. If you are unable to swallow the tablet in its entirety, cut it in half or crush it before mixing the tablets into one spoonful of applesauce. Consume the mix immediately without chewing. Don't store it for use later on. Mix the onfi suspension (liquid). Take a dosage using the measuring device provided (not an ordinary spoon).

Clobazam doses are determined by weight gain in teenagers and children. Your child's dose could be altered if they gain or lose weight. Seizures could rise if you stop taking Onfi abruptly. Do not stop taking Onfi without consulting your physician. There is a risk of severe withdrawal symptoms if you quit using the medication suddenly after long-term usage. Keep Onfi at room temperature, away from heat and moisture. Place your medication in a location where no one will use it in a way that isn't safe. Discard any oral suspension within 90 days of the first time you open the bottle.

Details on dosage

Usual Adult Dose of Onfi for Lennox-Gastaut Syndrome:

Initial total daily dose:
at least 30 kilograms: 5 mg daily
body weight over 30 kg, 10 mg taken orally daily
Day 7 total daily dose:
30-kg or less: 10 mg per day
If your body weight is greater than 30 kg, take a 20 mg oral dose per day.
Day 14 total daily dose:
Body weight of at least 30 kilograms: less than 20 mg daily
Body weight greater than 30 kg, 40 mg taken orally daily.

Usual Geriatric Dose of Onfi for Lennox-Gastaut Syndrome:

Initial dosage: 5 mg orally per day.
Day 7 total daily dose:
30 kg or less than 5 mg daily
A body weight of more than 30 kg, 10 mg oral dose per day
Day 14 total daily dose:
Body weight of 30 kg or less than 10 mg per day
Body weight greater than 30 kg 20 mg of oral medication per day
Maximum dose:
Body weight of at least 30 kilograms 20 mg/day
Body weight greater than 30 kg, 40 mg/day

Usual Pediatric Dose of Onfi for Lennox-Gastaut Syndrome:

2 years old or older:
First dose for the day:
Body weight of 30 kg or less than 5 mg daily
A body weight of more than 30 kg, 10 mg taken orally per day
Day 7 total daily dose:
30 kg or less than 10 mg per day
If your body weight is greater than 30 kg, take a 20 mg oral dose per day.
Day 14 total daily dose:
Body weight of 30 kg or less: 20mg daily
Body weight greater than 30 kg 40 mg of oral medication daily

A daily dose of more than 5 mg must be administered in divided doses two times per day.
Doses shouldn't be escalated faster than once a week.
Doses should be gradually removed by reducing the daily dosage by 5–10 mg per week until discontinuation.

Treatment for seizures that are a result of LGS

What happens if I miss the dose?

Do not take the medicine for as long as you can. However, avoid your missed dosage if you are nearing the time to take the next dose. Don't take two doses at a time.

What happens if I overdose?

For medical emergencies, seek immediate attention, contact emergency medical attention, or call the Poison Help Line at 1-800-222-1222. A clobazam overdose could be fatal when taken along with alcohol, opioid medication, or any other drug that can result in drowsiness or a slowing of your breathing.

The symptoms of an overdose can be extreme drowsiness, weakening, and confusion, as well as slower breathing or loss of consciousness.

What should be avoided?

Beware of drinking the alcohol. Dangerous side effects or death may occur. Avoid driving or engaging in hazardous activities until you are aware of the effects of this medicine on you. Dizziness or drowsiness may result in accidents, falls, or even serious injuries.

Side effects of Onfi

Take immediate medical care. If you are experiencing symptoms that indicate an allergy reaction (hives and breathing difficulties, or swelling in your throat or face) or a severe skin reaction (fever, sore throat, burnt eyes, irritation, and a red or purple skin eruption with peeling and blistering),

Onfi can slow or even stop your breathing, particularly in the event that you've recently consumed an opioid drug or alcohol. Anyone who cares for you needs to seek urgent medical treatment if you suffer from slow breathing with pauses for long periods and blue lips, or if you find it difficult to get up.

If you notice any new or more severe symptoms, you should report them to your physician, for example, mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you are feeling angry, irritable, impulsive, or aggressive. anxious, hyperactive (mentally as well as physically), depressed, or contemplating suicide or harming yourself.

See your doctor right away. If you are suffering from:

  • Breath that is weak or sluggish;
  • Severe drowsiness, feeling like you might pass out; or
  • Difficulties with balance or movement.

The symptoms of dizziness and drowsiness may be more frequent in older individuals. Be careful to stay away from falls or injuries that are accidental.

Common Onfi side effects could include:

  • Drowsiness, tiredness, trouble sleeping;
  • Slurred speech
  • Anger, aggression;
  • Constipation;
  • Painful urination;
  • Cough, fever, breathing issues, or
  • Drooling.

This is not a comprehensive list of possible side effects, and other effects may also be present. Contact your physician for advice regarding medical adverse effects. You can report adverse reactions to the FDA at 1-800-FDA-1088.

Interaction with other drug

Take Onfi together with other medicines that make you sleepy or cause breathing problems, which can result in dangerous negative side effects or even death. Ask your doctor prior to taking opioids, a sleeping pill, muscle relaxers, or medication for seizures or anxiety.

Other medications can be incompatible with clobazam, such as medications that are prescribed and available over the counter, vitamins, and herbal products. Inform your physician about any other medications you take.