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Naproxen and pseudoephedrine

Generic Name: Naproxen and pseudoephedrine [na-PROX-en-and-soo-doe-e-FED-rin]
Names of Brands: Aleve Cold and Sinus, Aleve Sinus and Headache, Aleve Sinus and Cold, Aleve-D Sinus, and Aleve Sinus and Cold Sudafed Sinus Twelve Hours of Pressure and Pain Show the 10 brands.
Dosage Format: Oral tablet, extended release (220 mg–120 mg)
Classification of Drugs: Upper respiratory combinations

What is Naproxen and pseudoephedrine?

Naproxen can be described as a nonsteroidal anti-inflammatory medication (NSAID). Pseudoephedrine can be used as an anti-congestant.

Naproxen and pseudoephedrine are combination medicines to treat nasal stuffiness, sinus congestion, headaches, fever, and minor pains and aches caused by an illness like the typical cold or flu.

Naproxen and pseudoephedrine could also be used to treat conditions not covered in this medication guide.

Side effects of Naproxen and pseudoephedrine

Contact emergency medical assistance in the event that you exhibit symptoms warning signs of an allergic response (hives, breathing difficulties, or feeling lightheaded and swelling of your throat or face) or a severe skin reaction (fever, sore throat, burning sensation within your eye, skin irritation where the skin is red or purple, itchy eruption that spreads and leads to peeling and blisters).

Seek medical attention immediately. If you are experiencing indications of stroke or heart attack: chest pain spreading into your shoulder or jaw A sudden feeling of weakness or numbness in one part of your body; speech slurring; leg swelling; or feeling short of breath.

Naproxen and pseudoephedrine could result in serious adverse side effects. Stop using the drugs naproxen and pseudoephedrine and contact your doctor immediately if you experience:

  • Severe dizziness or nervousness; trouble sleeping;
  • Swelling and rapid weight gain
  • Breathlessness;
  • New or progressively worsening stomach pain
  • Indications of stomach bleeding: bloody or black stools and coughing up blood. vomiting that resembles coffee grounds.

Common adverse effects of naproxen and pseudoephedrine can be:

  • Heartburn, stomach pain, vomiting, vomiting;
  • Dizziness;
  • Sleep problems (insomnia);
  • Feeling anxious or nervous.

This isn't an exhaustive listing of all negative side consequences. The possibility of other adverse side effects is possible. Talk to your doctor for medical advice about adverse effects. It is possible to report any symptoms to the FDA by calling 1-800-FDA-1088.


Naproxen may increase the risk of a fatal cardiovascular attack or stroke. Don't take this medication immediately prior to or following the heart bypass surgery (coronary bypass graft for the artery, also known as CABG). Naproxen could also trigger bleeding in the stomach or intestines and cause fatal bleeding.

Before you take this drug

Naproxen could increase the chance of having a fatal heart attack or stroke, even if you suffer from any of the risk factors. Don't use naproxen or pseudoephedrine prior to or after coronary bypass surgeries (coronary bypass graft for artery bypass, or CABG).

Naproxen can also trigger bleeding in the stomach or intestines, which can lead to fatal bleeding. These problems can develop in a matter of minutes when you are using naproxen and are more common among older adults.

It is not recommended to use this medication if you are allergic to pseudoephedrine or naproxen or if you've ever experienced an asthma attack or an extreme allergic reaction after using aspirin or an NSAID.

Avoid using naproxen or pseudoephedrine if you have taken an MAO inhibitor within the last 14 days. A potentially dangerous interaction between the two drugs could occur. MAO inhibitors are isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine, as well as others.

Consult a pharmacist or doctor to determine if this medication is suitable for use if you are suffering from:

  • Coronary illness, high blood pressure, diabetes;
  • A heart attack or stroke;
  • A stomach ulcer or bleeding
  • Asthma;
  • A thyroid disorder
  • Prostate enlargement Prostate and urinary issues;
  • Kidney or liver disease,
  • If you consume three or more alcoholic drinks each day.

Do not take naproxen or pseudoephedrine during pregnancy unless you are advised to by your doctor. The use of an NSAID in the final 20 weeks could cause harm to the baby's unborn child or trigger pregnancy-related complications.

Consult your doctor prior to using this medicine if you are nursing.Not authorized to be used by anyone less than 12 years old.

How to Take Naproxen and pseudoephedrine?

Follow the directions on the label or as directed by your physician. Make sure you are using the dosage that will be effective in treating your condition.Suck the tablet completely, and make sure you don't chew, crush, or break it.

Consume this medicine along with a glass full of water.Drink it in combination with milk or food. If this medicine causes upset in your stomach,If you're planning to undergo any kind of procedure, inform the surgeon in advance if you've taken this medicine in the last couple of days.

Consult your doctor if you are suffering from a fever that lasts more than 3 days or if your symptoms don't improve after seven days of taking the medicine.

Place it in a cool, dry place free of heat and moisture.

Details on dosage

Usual Adult Dose for Nasal Congestion:

Naproxen 220 mg or pseudoephedrine 120 mg per tablet: One tablet to be taken orally at 12-hour intervals:
Maximum dose: 2 tablets per 24 hours.

Usual Adult Dose for Analgesics and Antipyretics:

Naproxen 220 mg/pseudoephedrine 120 mg/tablet 1 tablet taken orally every 12 hours
Maximum dose: 2 tablets per 24 hours.

Usual Pediatric Dose for Nasal Congestion:

Naproxen 220 mg and pseudoephedrine 120 mg per tablet:
12 years old and over 1 tablet taken orally at least every twelve hours
Maximum dose: 2 tablets per 24 hours.

Usual Pediatric Dose for Analgesics and Antipyretics:

Naproxen 220 mg and pseudoephedrine 120 mg per tablet:
12 years old and over 1 tablet at least every twelve hours
Maximum dose: 2 tablets per 24 hours.

What happens If I miss a dose?

Because cold medication is taken whenever needed, you may not be on a regular dosing schedule. Do not miss any doses in the event that it's nearing the time to take the next dose. Don't take two doses at once.

What happens If I overdose?

Get medical attention in an emergency or contact the Poison Help line toll-free at 1-800-222-1222.

What should be avoided?

Beware of drinking alcohol. It can increase the chance of bleeding from your stomach.Do not take aspirin unless your doctor advises you to.

Talk to your doctor or pharmacist before taking any other medicine for a cough or cold that may have similar components.

Interaction with other drugs

Consult your physician before taking naproxen or pseudoephedrine when you are taking any antidepressant. Taking certain antidepressants along with an NSAID can cause bleeding or bruises easily.

Consult a physician or pharmacist prior to using naproxen and pseudoephedrine along with any other medication, particularly:

  • The blood thinners (warfarin, coumadin, and Jantoven);
  • Blood pressure or heart medication such as diuretics or "water pills";
  • Steroid medicine (such as prednisone).

This list is not comprehensive. Other medications can affect naproxen or pseudoephedrine, such as prescription and over-the-counter medicines, vitamins, and herbal products. Some interactions with drugs are not listed here. are listed here.



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