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Naloxone and pentazocine

Generic Name: Naloxone and pentazocine (oral) [nal-OX-one-and-pen-TAZ-oh-seen]
Name of the Brand: Talwin NX
Dosage Format: Oral tablet (0.5 mg to 50 mg)
Drug Class: Narcotic analgesic combinations

What is Naloxone, pentazocine?

Naloxone inhibits some effects of opioids that can cause feelings of wellbeing, which can result in opioid addiction. Pentazocine can be described as an opioid painkiller.

Naloxone and pentazocine are an effective combination medication used to manage mild to extreme pain for adults and children who are at least 12 years old. Naloxone is used in this medicine to help prevent the abuse of opioids.Pentazocine and Naloxone may be used for other purposes that are not covered in this medication guide.

Side effects of Naloxone and pentazocine

Contact emergency medical assistance. If you notice symptoms that indicate an allergic reaction (hives, breathing problems, and swelling in your throat or face) or an extreme skin reaction (fever and sore throat, burning sensations in your eyes, pain in the skin, and red or purple skin itching that can cause peeling and blisters),

Opioid medicines can slow or stop your breathing, and death could occur. Anyone who cares for you must administer Naloxone and/or seek medical attention if you experience breath that is slow, with long pauses or blue-coloured lips, or if it is difficult to get up.

Naloxone and pentazocine can result in serious adverse reactions. Contact your doctor immediately in the event of:

  • Loud breathing, sighing, and breathing shallowly that stops;
  • A low heart rate or a weak pulse
  • A feeling of lightheadedness, as if you've passed out;
  • Serious constipation;
  • Hallucinations, confusion, strange thoughts, or behaviour;
  • A seizure;
  • Low levels of cortisol: the feeling of nausea, vomiting, a loss of appetite, nausea, fatigue that is worsening, or weakness;
  • Agitation and hallucinations are symptoms of serotonin syndrome. Fever, fast heart rate, muscle stiffness, loss of coordination, twitching, vomiting, and diarrhoea

Breathing problems that are serious could be more common in older adults and those with debilitating conditions or who suffer from chronic wasting syndrome and chronic breathing problems.

Common adverse effects of naloxone or pentazocine can include:

  • Dizziness, drowsiness;
  • Constipation;
  • Stomach pain, nausea, vomiting,
  • Feeling exhausted.

There isn't an exhaustive listing of all negative results. Other scenarios could occur. Talk to your doctor for advice from a medical professional regarding adverse reactions. If you have any concerns, report the allergic reactions or symptoms to the FDA by calling 1-800-FDA-1088.


A MISUSE OF OPIOID MEDICINE could lead to addiction, overdose, or even death. Make sure the medication is safe from anyone else. it.Utilising opioids during pregnancy can result in life-threatening withdrawal symptoms for the baby.

The risk of fatal side effects could be experienced if you take opioids in conjunction with alcohol or other substances that can cause drowsiness or slow breathing.

Before you take this drug

Naloxone and pentazocine should not be used if you are allergic to pentazocine or naloxone or if you suffer from:

  • Extremely severe asthma or breathing issues such as
  • A stomach issue or obstruction of the bowel (including paralytic ileus).

Inform your doctor if you were ever diagnosed with:

  • Breathing difficulties; sleep apnea (breathing stops while sleeping);
  • A head injury, brain tumour, or seizures;
  • Urination issues;
  • Kidney disease or liver failure;
  • Issues with your gallbladder, thyroid, or pancreas;
  • Alcoholism, addiction to drugs,
  • If you've taken an MAO inhibitor within the last 14 days, like linezolid and isocarboxazid, as well as phenelzine, methylene blue injection, or tranylcypromine,

If you take opioids while pregnant, your child could develop dependence on the medication. This can cause severe withdrawal symptoms for the newborn after it's born. Children who are dependent on opioids could require medical attention for a few weeks.

Consult a physician before taking opioids if you are nursing. Tell your doctor when you experience severe fatigue or a slow breathing rate in your baby.Naloxone and pentazocine are not allowed for use by people younger than

How to take Naloxone and pentazocine?

Follow the instructions on your prescription label and go through all the medication guidelines. Do not use pentazocine and naloxone in greater quantities or for a longer duration than what is prescribed. Talk to your doctor if you notice an increase in your desire to take this drug.

Don't share opioids with a person, particularly one with an addiction history. The misuse of opioids can lead to addiction, overdose, or death. Place the medication in a place where no one else can access it. Giving away or selling this medication is against the law.Naloxone and pentazocine are typically consumed in the form of 1 or 2 tablets every 3–4 hours. Follow the directions of your doctor. Don't take more than 12 tablets within the span of 24 hours.

If you're taking any other pain medication that is a narcotic, the pain-reducing effects of the narcotic might be reversed if you are also taking pentazocine and naloxone.Do not crush pills to inhale them or inject the powder into your vein. It could cause death.Do not stop using this medicine abruptly. Follow your doctor's advice on the process of tapering your dose.

Place it in a cool, dry place far from heat and moisture. Be aware of the medication you are taking. You must be aware if someone is taking it incorrectly and without a prescription.

Don't store any leftover medication for opioids. A single dose can cause death if someone is taking the medication in error or incorrectly. Ask your pharmacist for the location of a drug disposal programme that takes back the drug. If there isn't a taking-back system, then flush any remaining medicine into the toilet.

What happens If I Miss a dose?

Since pentazocine and naloxone are used to treat pain, you're not likely to be able to miss a dose. Don't miss any dose in the event that it's almost time to take your next dose. Don't take two doses at once.Do not exceed 12 tablets within the course of a 24-hour time period.

What happens If I overdose?

Get medical attention immediately or contact the poison help line at 1-800-222-1222 for help. A fatal overdose of opioids can be fatal, particularly in the case of a child or another person who is taking the medication without a prescription. Overdose symptoms may include extreme drowsiness, sharp pupils, slow breathing, or even no breathing.

Your physician may suggest you purchase a non-combination type of naloxone to treat an overdose of opioids and carry it on hand throughout the day. The person who is caring for you could administer Naloxone if you cease breathing or don't awaken. Your carer needs to get emergency medical attention and could be required to perform CPR (cardiopulmonary resuscitation) on you as they wait for assistance to arrive.

Naloxone can be purchased from pharmacies or your local health department. It is important that everyone who cares for you is aware of the location where you keep your naloxone and how to make use of it.

What should be avoided?

Don't drink alcohol. Dangerous side effects or death may occur.Beware of driving or operating machinery until you understand how pentazocine and naloxone affect you. The effects of drowsiness and dizziness can result in falls or other accidents.

Do not smoke cigarettes, which could reduce the effectiveness of this medication in relieving discomfort.

Interaction with other drugs

Other drugs may be harmful when combined with opioid medications. Tell your doctor whether you use any of the following:

  • Medicine for asthma, allergies, blood pressure, motion sickness, and irritable bowel syndrome, as well as an overactive bladder;
  • Other opioid medications;
  • Benzodiazepine sedatives such as Valium, Klonopin, or Xanax;
  • Sleep medication such as muscle relaxers, sleep medicine, or other medications that can make you sleepy as well as
  • Medications that alter serotonin levels medications that affect serotonin, like antidepressants, stimulants, antidepressants, or medication to treat migraines and Parkinson's disease.

This list is not comprehensive. There are many drugs that can interact with pentazocine and naloxone, including prescription and over-the-counter medicines, vitamins, and herbal supplements. The interactions of all drugs are mentioned here.



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