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Generic name: mitapivat [ MYE-ta-PIV-at ]
Brand names: Pyramid, Pyramyd Taper Pack
Oral tablets: 20 mg, 5 mg, 50 mg, and 50 mg (20 mg).
Drug class: Miscellaneous metabolic agents

What is Mitapivat?

The treatment of low red cell counts in adults who have pyruvate-kinase deficiencies caused by hemolytic anemia is Mitapivat.

Mitapivat can be used in other ways not mentioned in the medication guide.

Side effects of Mitapivat

If you experience symptoms associated with allergies such as difficulty breathing, hives or swelling in your lips, face, throat or tongue; seek medical assistance immediately.

Mitapivat may cause serious side effects. If you experience:

  • Jaundice

  • Dark urine
  • Dizziness;
  • Confusion;
  • Tiredness;
  • Shortness of breath.

Some of the common side effects associated with mitapivat include:

  • Flushing (a sudden feeling of warmth, tingling, or redness);
  • Breast swelling and tenderness
  • Changes in Sexual Function
  • Heart rhythm irregularity
  • Blood tests that are abnormal
  • Back or joint pain.

There may be other side effects. For medical advice on side effects, call your doctor. Call the FDA immediately at 1-800-FDA-1088 if experiencing side effects and report it as soon as possible.


Dial your doctor immediately if you experience jaundice, dark urine, fatigue, confusion, or dizziness.

Before you take this drug

If you've ever:

  • Liver Disease.

Inform your doctor of any pregnancy or nursing.

How to take Mitapivat?

Read all of the instructions or guides included with your medication and follow all directions listed on its label.

Take mitapivat either with food or without.

Do not chew or crush the tablet.

You should not give mitapivat to anyone else, even if you share the same symptoms.

Consult your doctor before changing your dosage or stopping Mitapivat. You will be given instructions by your doctor on how to stop using mitapivat.

Keep this medication at room temperature in its original container.

What happens if I miss the dose?

If you miss a dose by more than four hours, you should use the medication as soon as possible. Never take two doses of the same medicine at once.

What happens if I overdose?

Reach out for help immediately or call 1-800-222-1222.

What should be avoided?

If your doctor prescribes any restrictions on foods, drinks, or activities, follow their instructions.

Interaction with other drug

At times, taking multiple medications simultaneously may not be safe. Some medicines can cause your blood level of another drug to increase, causing side effects and/or a decrease in effectiveness.

Mitapivat may be affected by other drugs, such as prescription or over-the-counter medications, vitamins, and herbal products. Inform your physician of any and all medications you are currently taking.