The Web Health



Generic Name: Macitentan [MA-si-TEN-tan].
The Brand Name: Opsumit.
Dosage Format: Oral tablet (10 mg).
The Class of Drugs: Agents for hypertension in the pulmonary system.

What is Macitentan?

Macitentan lowers blood pressure in the lungs, which helps the heart pump blood more efficiently. Macitentan helps treat the condition known as pulmonary arterial hypertension (PAH). It helps you exercise and also prevents the condition from getting worse. Macitentan is accessible to women only through an exclusive program through a pharmacy that is certified. It is necessary to be enrolled in the program, and you must be aware of the potential risks and benefits of the medication. Macitentan can be used for other purposes not covered in this guide.

Side effects of Macitentan

Contact a medical professional immediately. Get medical attention immediately if you notice symptoms that are warning signs of an allergic response, such as difficulty breathing, hives, or swelling of your lips, face, and tongue.

Macitentan may cause serious side effects. Stop taking Macitentan and contact your doctor immediately. If you suffer from:

  • Discomfort or burning sensation during urination.
  • Rapid weight gain and swelling.
  • Liver problems: nausea nausea, stomach pain in the upper part of the stomach, itching, fatigue, loss of appetite, black stools, dark urine, jaundice (yellowing of the eyes or skin), as well as.
  • New lung problems: anxiety, the appearance of pale skin, sweating, and severe breath shortness; wheezing, gasping for air; coughing with foamy mucus; chest pain; rapid or irregular heart rate.

Common adverse effects of macitentan could include:

  • Nasal congestion, sinus pain, sore throat.
  • A bladder infection.
  • Headache.
  • Flu symptoms (fever, chills, body aches).

This is not a comprehensive list of all the side effects. Others could happen. Contact your doctor for advice regarding medical effects. You can report any adverse reactions to the FDA at 1-800-FDA-1088.


Macitentan is not a good choice when you are pregnant or suspect that you are expecting. Use highly effective birth control to avoid pregnancy while using macitentan and for a minimum of 30 days after treatment has ended. It is necessary to perform a pregnancy test prior to and after the treatment using macitentan.

Before you take this drug

You shouldn't use macitentan if you have an allergy to it.

Speak to your doctor if you are ever diagnosed with:

  • The liver condition.
  • Coronary disease.
  • Anemia (low number of red blood cells).

The medicine could harm the unborn baby as well as cause birth defects. Don't take Macitentan when you are expecting or believe you might be expecting. Tell your doctor immediately if you have missed menstrual cycles or believe that you may be pregnant due to treatment. It is necessary to take an unconfirmed pregnancy test prior to commencing this treatment. The test will be repeated each month throughout the course of treatment and one month after you have stopped using this medication. Even if you're not planning to become pregnant, you are considered to have the possibility of becoming pregnant in the event that:

  • You have entered the puberty stage (even though you haven't yet started to experience menstrual flow).
  • You haven't ever had a surgery called a hysterectomy, been able to have your ovaries removed.
  • You haven't gone through menopausal changes (you haven't ever gone for 12 months without a menstrual cycle).

When you are taking macitentan for the next 30 days following your last dose, it is essential to use a highly effective method of birth control, or use two methods.

  • A tubal ligation by itself is a reliable birth control technique.
  • An intrauterine device (IUD) as well as birth control implants on their own are both effective methods for birth control.
  • If you are using birth control pills, injectable skin patches, or vaginal rings, it is essential to use a backup barrier type of birth control like a condom, cervical cap, or diaphragm. Always make use of spermicide gel or add it to an alternative form of birth control.
  • If you are using only one barrier method, it is essential to employ a second barrier technique to serve as a backup. For instance, you can utilize a diaphragm or cervical cap in addition to condoms and insert spermicide gel.
  • If your partner's sexual partner has undergone a vasectomy, you still need to use an alternative method to control births, either an invasive method or a hormonal type (birth control pills, injectables, patches for the skin, as well as a vaginal ring).

Macitentan comes with instructions for patients on acceptable forms of birth control that you can use while using this medication. Follow these guidelines carefully. Consult your physician or pharmacist if you have any concerns. If you're the caregiver or parent of a girl who is taking this medicine, consult the child's physician if you observe any indication of puberty (breast growth and pubic hair), even if your menstrual cycles haven't yet started. Macitentan may reduce sperm count and impact men's fertility (their potential to bear children). It is not recommended to breastfeed during the course of this medication.

How to take Macitentan?

Follow the directions on the prescription label and review all medication guides and instruction sheets. Follow the medication exactly as prescribed. Macitentan is a supplement with or without meals. Take the tablet in one swallow and don't crush, chew, or break it. If you take macitentan, you might need to conduct regular blood tests. Keep at room temperature, free of heat and moisture.

Details on dosage

Usual Adult Dose for Pulmonary Hypertension:

10 mg orally every day.
Uses: In the treatment of hypertension in the pulmonary artery (PAH, WHO Group I) to slow the progression of disease.

What happens if I miss a dose?

You should take the medication as quickly as you are able, but do not take any missed doses if it's nearing the time to take the next dose. Don't take two doses at once.

What happens if I overdose?

Get medical attention in an emergency or contact the poison help line at 1-800-222-1222.

What should be avoided?

Do not engage in unprotected sexual contact when you are taking macitentan. You should use birth control to prevent pregnancy during treatment and for a minimum of 30 days following the time you stop using macitentan.

Interaction with other drugs

Other medications can affect macitentan, such as prescription and non-prescription medicines, vitamins, and herbal products. Be sure to inform your health professionals about the medicines you are taking now and any medication you stop or start using.