Mifeprex

What is Mifeprex?

Mifeprex inhibits the action of an essential hormone for maintaining a pregnancy.The Mifeprex medication is prescribed to terminate an early pregnancy lasting up to 70 days (ten weeks) following the last day of your menstrual cycle. The Mifeprex medication is taken with misoprostol, also known as Cytotec.Mifeprex can be obtained from certified healthcare providers and certified pharmacies under a program. Mifeprex must be taken by a registered participant who understands the associated risks.DO NOT USE MIFEPREX TO STOP PREGNANCY AFTER 10 WEEKS.The Mifeprex brand of mifepristone is covered in this medication guide. This medication guide does not cover Korlym, another brand of Mifepristone.Mifeprex can be used in other ways not mentioned in the medication guide.

Side effects of Mifeprex

If you experience any of the following symptoms of an allergy reaction, seek immediate medical attention: difficulty breathing, hives, swelling in your lips, face, throat, or tongue.

Mifeprex can cause severe side effects. If you experience:

• A fever that lasts more than four hours and is higher than 100,4 degrees F.
• Feeling very sick, confusion, high fever, chills, or severe sleepiness;
• A general feeling of ill-will or rapid heartbeats.
• Severe pelvic pain and tenderness
• Severe or ongoing nausea, vomiting, diarrhea, or weakness;
• There was no vaginal bleeding after Mifeprex.

Mifeprex side effects may include:

• Heavy vaginal bleeding lasting 2 days
• Light vaginal bleeding for up to sixteen days.
• Fever, chills, weakness;
• Dizziness;
• Nausea, vomiting, and diarrhea.

There may be other side effects. For medical advice on side effects, call your doctor. Call the FDA's Hotline, at 1-800-FDA-1088, if experiencing side effects.

Warnings

The Mifeprex brand of mifepristone is covered in this medication guide. This medication guide does not cover Korlym, another brand of Mifepristone. The combination of Mifeprex and Misoprostol is prescribed to terminate an early pregnancy. MIFEPREX SHOULD NOT BE USED TO TRY AND END A PREGNANCY AFTER 10 WEEKS. Avoid using Mifeprex and misoprostol to terminate your pregnancy. If you experience heavy vaginal bleeds or feel ill after using Mifeprex, call your doctor immediately. If you have symptoms of Mifeprex, misoprostol, and other medications more than 24 hours later, seek emergency medical attention.

Before you take this drug

Mifeprex can cause birth defects if it is not used to terminate the pregnancy. It may be necessary to have surgery in order to terminate the pregnancy. Mifeprex treatment requires two visits to the doctor. This medicine should not be used if you are unable to attend the required appointments.

Mifeprex and misoprostol should be avoided if either of these conditions apply:

• It has been over 70 days (more than 10 weeks) since you last had a period.
• You cannot get immediate medical attention if you need it in the two weeks following your use of these medications.
• You have an IUD or intrauterine device (it needs to be removed prior to taking Mifeprex);
• You have an ectopic pregnancy.
• You have chronic adrenal dysfunction.
• You have a blood-clotting or bleeding disorder such as hemophilia.
• You have porphyria.
• You have a medical condition that requires you to use blood thinners, such as Warfarin. (Coumadin or Januarytoven).
• You have had a chronic condition that you've been treating with steroid medication for many years.
• You are allergic to prostaglandins.

Tell your doctor about any of the following to ensure that Mifeprex will be safe for you:

• A history of uterine fracture or scarring.

Mifeprex may pass through breast milk, which can harm nursing babies. You should tell your doctor that you are breastfeeding a child.

How to take Mifeprex?

Read all the instructions or guides that come with your medication and follow all the directions. Follow the directions on your prescription label. You must first read the Mifeprex medication guide before receiving Mifeprex. You must then sign the Patient Agreement Form, stating that you have read and understood all of the information about this medication. At least two visits to the doctor are required to complete treatment.

• You will receive a Mifeprex tablet at your first appointment (Day 1). Also, you will be prescribed or given 4 tablets of misoprostol. You should fill out the misoprostol prescription if you only received a prescription.
• You will need to take four misoprostol pills in 24 to 48 hours. You must take Misoprostol within 24 to 48 hours of taking Mifeprex for the treatment to work.
• Misoprostol may cause nausea, diarrhea, and cramps. You may be prescribed medicine by your doctor to prevent or treat these side effects.
• Within 2–24 hours of taking misoprostol, your uterus will begin to expel the pregnancy. Make sure that you're in an area where you can be prepared for the event. While your uterus passes the pregnancy, you will probably experience heavy vaginal bleeds.
• Your doctor will examine your uterus at the second appointment (days 7–14 after taking Mifeprex) to ensure that the pregnancy is over.
• You may receive another misoprostol dose if your body is not able to pass the pregnancy. You should see your doctor 7 days after taking a second misoprostol dose.

When a medicine works properly, it will cause bleeding and cramping. You can still be pregnant and have bleeding or cramps. Your doctor is the only one who can tell you if your pregnancy is over. A home pregnancy test will not confirm that it's been cleared. Don't miss your scheduled follow-up appointments. It may be necessary to have surgery in order to terminate the pregnancy. If you carry a pregnancy until term, it may result in birth defects or even death for the child. Speak to your doctor regarding your options. Mifeprex, misoprostol, and other medications can cause bleeding and spots. Bleeding can continue for 30 days. You may experience heavier bleeding than usual, as well as passing blood clots or tissue. If you experience heavy vaginal bleeding or a general feeling of unwellness for more than 2 hours straight, call your doctor. Serious and even fatal bleeding (or infection) may follow the termination of a pregnancy. If you are experiencing heavy bleeding, or have an unwell feeling, call your doctor. Other symptoms include a high fever, abdominal pain, or rapid heartbeats.

If you have symptoms of misoprostol more than 24 hours later, go to the emergency room. Fever, severe stomach cramping, prolonged or heavy vaginal bleeding. Tell your caregivers the last time you took misoprostol. After terminating your pregnancy, it is possible for you to become pregnant again. After your doctor confirms that Mifeprex treatment has ended the pregnancy, you can start using.

What happens if I miss the dose?

Mifeprex does not require a schedule of daily doses. If you do not attend your follow-up appointments, call your doctor to get instructions.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

If your doctor prescribes any restrictions on foods, drinks, or activities, follow their instructions. Mifeprex can be metabolized more slowly by your body if you consume grapefruit or juice. Use grapefruit juice or other products before taking Mifeprex.

Interaction with other drug

Inform your doctor of all medications you are currently taking. Mifeprex may be affected by many drugs, including:

• John's wort;
• Hepatitis and hiv medications
• Antifungal or antibacterial medication
• Heart or blood pressure medications;
• Seizure medication;
• Tuberculosis medication

Mifeprex can be affected by many drugs. Some drugs shouldn't be taken together. Inform your doctor of all the medicines that you take. Included are prescription, over-the-counter, and herbal medicines. This list does not include all interactions.