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Midol PM

Generic name: Acetaminophen and diphenhydramine [a-SEET-a-MIN-oh-fen and DYE-fen HYE dra meen] should only be taken when necessary.
Brand names: Headache Relief PM products such as Legatrin PM, Midol PM, Percogesic Original Strength and Tylenol PM can provide pain relief during the night time hours.
Drug class: analgesic combinations

What is Midol PM?

Acetaminophen relieves pain and reduces fever. Diphenhydramine acts as an antihistamine. The combination medication Midol PM treats occasional insomnia that is associated with minor pain. Midol PM should not be used to treat insomnia with pain or frequent sleep disorders. The Midol PM can also be used for minor pains and aches such as a headache, pain in the back or muscles, joint pain, pain of teeth, or cramps. The flu, the common cold, or allergies can also be treated with Midol PM. This medication guide does not list all possible uses of Midol PM.

Side effects of Midol PM

If you experience any of the following symptoms of an allergy: difficulty breathing, hives, swelling in your lips, face, throat, or tongue. Acetaminophen can cause severe reactions in some cases. This is even true if the person has taken it before and not had any reaction. Call your doctor immediately if the skin becomes red or you develop a rash. If blisters form and you peel them off, stop taking this medication.

This medicine can cause severe side effects. If you experience:

  • Severe sleepiness
  • Urination that is painful or difficult
  • Liver problems: loss of appetite, nausea, fatigue, itching, and dark urine.

Some of the common side effects that Midol PM can cause include:

  • Drowsiness;
  • Constipation;
  • Reduced urination
  • Dry eyes and blurred vision
  • Dry throat, mouth, or nose.

There may be other side effects. For medical advice on side effects, call your doctor. Submit reports of adverse events by calling the FDA at 1-800-FDA-1088.

Warnings

Midol PM should be used exactly according to the instructions. Overdosing on acetaminophen may cause liver damage or death. Diphenhydramine overdose can cause serious heart issues, seizures, death, and coma. Never use this medication to put a young child to sleep. Before using any other medication that contains acetaminophen or diphenhydramine, consult your doctor or pharmacist. Overdosing on either medication can be fatal. When taking acetaminophen, drinking alcohol can increase the risk of developing liver damage. If you notice skin redness, a rash, or blisters that are peeling off and spreading on your body, then stop taking the medicine immediately and contact your doctor.

Before you take this drug

If you've ever suffered from liver disease or drink more than three alcoholic drinks per day, you should consult a physician before you take a medicine containing acetaminophen.

If you've ever:

  • Liver disease
  • Urination or prostate problems;
  • Asthma, COPD, emphysema, or any other breathing disorder.
  • Glaucoma;
  • A condition that you are taking warfarin for (coumadin or Jantoven).

Before using this medication, consult your doctor if you're pregnant or nursing. Diphenhydramine can slow down breast milk production.

How to take Midol PM?

Follow the instructions on the bottle or those prescribed by your physician. Use Midol PM only as needed until symptoms are resolved. Midol PM should not be taken in excess of the recommended dose. Overdosing on acetaminophen may cause liver damage or death. Diphenhydramine overdose can cause serious heart issues, seizures, death, and coma. The use of Midol PM in children younger than 12 is prohibited. Never use this medicine to put a young child to sleep. Use this medication for no more than two weeks to treat sleeping problems or seven days to treat allergy or cold symptoms. If you have not seen improvement in your symptoms after three days or if the pain persists after ten days (or five days for those aged 12–17), call your doctor. Call your doctor as soon as your symptoms worsen or you notice any swelling or redness. Tell your doctor if this medication was taken within the last few days and if you are going to need medical testing or surgery. Keep away from heat and moisture at room temperature.

What happens if I miss the dose?

You may not have a schedule for taking Midol PM, as it is only used when necessary. If it is almost time to take your next dose, skip any missed doses. Never take two doses in one go.

What happens if I overdose?

Call Poison Help at 1-800-222-1222 or seek emergency medical care. Overdoses can cause death or liver damage. The symptoms of an overdose may include nausea, a loss of appetite, and vomiting. Other signs can be confusion, feeling weak, having a ringing sound in your ears or upper stomach, dry mouth or skin, dark urine, or no urination.

What should be avoided?

Do not drive or engage in hazardous activities until you have determined how Midol PM will affect you. You may be unable to react properly. Before using any other medication that contains acetaminophen or diphenhydramine, consult your doctor or pharmacist. Included are medicines used to treat pain, fevers, swellings, flu symptoms, or skin itch. An overdose of acetaminophen and diphenhydramine may be fatal. When taking acetaminophen, drinking alcohol can increase the risk of developing liver damage.

Interaction with other drug

Before using Midol PM, consult your doctor or pharmacist. This is especially important if you are taking any medications that may cause drowsiness, such as sleep medication, opioid medication, muscle relaxants, anxiety medicines, or seizure medicine. Inform your doctor of all the medicines you are currently taking and those that you have started or stopped using. Included are prescription, over-the-counter, herbal, and other products. This list does not include all interactions.