What is Mepsevii?
Mepsevii is a supplement that contains a natural enzyme found in people who are healthy. A genetic disorder can cause some people to lack this enzyme. The medicine replaces the missing enzyme. Mepsevii is used to alleviate some of the symptoms associated with mucopolysaccharidosis VII (pronounced MYOO-koe-pol-ee-SAK-a-rye-DOE-sis Seven), commonly referred to as Sly syndrome. MPS VII is a metabolic disorder where the body is lacking the enzymes required to break down certain natural substances. The substances that build up can cause enlarged organs and abnormal bone structures, as well as breathing or heart problems. They may also lead to changes in facial appearance, mental or physical disabilities, or even vision loss. Mepsevii can improve the walking abilities of people who have this condition. This medication does not cure MPS VII. Mepsevii can be used in other ways not mentioned in the medication guide.
Side effects of Mepsevii
Symptoms of allergy reactions that require immediate medical intervention: difficulty breathing, hives or swelling on lips, face throat or tongue. A severe allergic reaction can occur shortly after or during the infusion of Mepsevii. If you experience any of the following symptoms, tell your caregivers immediately or seek emergency medical attention.
- Feeling like you could pass out even when lying down
- Clammy or cold skin;
- Feeling short of breath
- Pale skin;
- Blue lips or fingernails.
Mepsevii can cause side effects such as:
- Diarrhea;
- You may experience swelling in your feet or hands.
- Rash, itching;
- An IV needle may lead to swelling and discomfort.
There may be additional side effects. For medical advice regarding side effects, speak to your healthcare provider; report side effects by calling the FDA's reporting line at 1-800-FDA-1088.
Warnings
A severe allergic reaction can occur shortly after or during the infusion. If you experience any symptoms of an allergic reaction that are severe, such as difficulty breathing, sweating, pale lips, or blue fingernails or skin, or feel like you may pass out, tell your caregivers right away or seek emergency medical attention.
Before you take this drug
If you've ever:
- A lung condition or problems breathing.
Inform your doctor of any pregnancy or nursing.
How to take Mepsevii?
Mepsevii can be infused into the vein. This injection will be given by a healthcare professional. Mepsevii can be given every two weeks. Mepsevii is given very slowly and can last up to 4 hours. Prevent an allergic reaction and get additional medication 30-60 minutes prior to every injection with another treatment plan. If you experience any pain or swelling when Mepsevii injections are given, tell your caretakers. After receiving Mepsevii, you will be closely monitored for 60 minutes to ensure that there is no allergic reaction. The dose of Mepsevii is based on your weight. As your weight fluctuates, so will your dosage requirements.
What happens if I miss the dose?
If you missed your appointment to receive Mepsevii, call your doctor and ask for directions.
What happens if I overdose?
Contact 1-800-222-1222 immediately in case of poisoning and seek emergency medical help as quickly as possible.
What should be avoided?
If your doctor prescribes any restrictions on foods, drinks, or activities, follow their instructions.
Interaction with other drug
Mepsevii may be affected by other drugs, such as prescription or over-the-counter medications, vitamins, and herbal products. Inform your doctor of all the medicines you are currently taking and those that you have started or stopped using.
