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Generic name: irinotecan liposomal [EYE-ri-noe-TEE-kan-LYE-poe-SOE-mal]
The class of drug: miscellaneous antineoplastics

What is Onivyde?

Onivyde can be used for treating pancreatic cancer that has spread to other regions within the human organs (metastatic). The medication is typically taken in conjunction with cancer medications. Onivyde is also used for reasons not mentioned in this guideline for medication.

Side effects of Onivyde

Contact a medical professional immediately in the event that you exhibit symptoms or warning signs of an allergic response, such as hives, chest tightness, wheezing, difficulty breathing, or swelling of your lips, face, or tongue.

Onivyde can cause serious adverse side effects. Consult your physician right away in the event of:

  • Persistent or severe persistent vomiting and diarrhoea;
  • Black or bloody stool;
  • Sores or white patches on your mouth or around it;
  • A new or getting worse or worsening cough or breathlessness;
  • Dehydration symptoms: feeling extremely hot or thirsty and being in a state of not being able to urinate; heavy sweating or dry and hot skin;
  • Low blood cell counts low blood cell counts, fever and fatigue, and skin rashes, as well as easy bleeding and unusually white skin. The feeling of cold feet or hands; feeling lightheaded or
  • Signs of symptoms of sepsis—confusion symptoms of sepsis include fever or chills, severe sleepiness, and rapid heartbeats. Fast breathing and feeling sick.

Common negative effects of onivyde include:

  • Sores in the mouth or other symptoms of an infection;
  • Diarrhoea;
  • Nausea or vomiting or loss of appetite or
  • Feeling tired or weak.

This isn't an exhaustive list of all the side effects. Others could happen. Consult your physician for advice regarding medical effects. You may report any adverse reactions to the FDA at 1-800-FDA-1088.


Onivyde may cause severe diarrhoea, which could be life-threatening. Consult your doctor when you notice diarrhoea while on the treatment you receive from Onivyde.

Before you take this drug

This medication if you have an allergy to the irinotecan.

Inform your doctor if you were ever diagnosed with:

  • Kidney disease or liver failure;
  • Lung disease; or
  • An intestinal obstruction or disorder.

Onivyde could harm an unborn baby when the father or mother is taking this medication.

  • If you're female, you may need to undergo a pregnancy test. Utilise the most effective contraception to stop pregnancy while taking this medication and for at least one month following your last dose.
  • If you're male, use condoms if your partner has the potential to become pregnant. Continue using condoms for at least 4 months after the last time you used them.
  • Contact your physician immediately. If you become pregnant during the time that both the mother and father are taking Onivyde,

How to take Onivyde?

Onivyde is administered as an injection into the vein. The healthcare professional will give the injection. Onivyde is best administered slowly, and the infusion may take as long as 90 minutes to finish.

Onivyde causes severe diarrhoea that could be life-threatening if it causes dehydration. Your doctor might suggest keeping anti-diarrhoea medications in your bag throughout the day (such as loperamide and modium). Use this medication when you first notice a loss of or frequent diarrhoea. Do not use loperamide for more than two full days without consulting your physician.

Consult your physician any time you feel that you are having diarrhoea as a result of your treatments with onivyde. It is possible that you will require frequent medical tests to make sure this medication does not cause negative side effects. The treatment for cancer may be delayed, depending on the results.

What happens if I miss the dose?

Consult your physician for the appropriate treatment. If you do not make an appointment for Onivyde,

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help Line toll-free at 1-800-222-1222.

What should be avoided?

Avoid driving or engaging in hazardous activities until you understand how the onivyde affects your body. Your reaction may be impaired. Avoid being around those who are sick or suffering from infections. Inform your doctor immediately when you begin to show symptoms of an infection

Interaction with other drug

There are times when it's not recommended to use certain medicines in combination. Certain drugs may affect the blood levels of the other drugs that you take, which can create side effects or render the medication less effective.

Numerous drugs can influence Onivyde's health. This includes over-the-counter and prescription medications, vitamins, and herbal supplements. There are not all the interactions mentioned here. Discuss with your physician all the medications you are currently taking and any medication you begin or stop taking.