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Mannitol inhalation

Generically: Mannitol inhalation [MAN-i-tol] [MAN-iTOL].
Names of Brands: Aridol, Bronchitol.
Dosage Forms: Inhalation pill (40 mg) and kit.
Drug Class: Miscellaneous diuretics.

What is Mannitol Inhalation?

Bronchitol is utilized in conjunction with other medications to improve breathing in people suffering from cystic fibrosis. Bronchitol is administered only after you have been able to pass a tolerance test in order to ensure that you are able to safely take mannitol by inhalation.

Aridol: Aridol is utilized as part of medical tests to treat asthma in children who are at least six years old. Mannitol inhalation can also be employed for reasons not mentioned in this guideline.

Side effects of Mannitol Inhalation 

Contact a medical professional immediately. If you are experiencing symptoms that indicate an allergic reaction, such as difficulty breathing, hives, or swelling of your lips, face, and tongue.

Mannitol inhalation may cause serious side effects. If you have any of the following symptoms, please contact your doctor right once:

  • Wheezing or choking, other breathing problems following the use of this medication.
  • If you cough up huge amounts of blood.

Common adverse reactions to bronchitol could be:

  • Irritation or pain in your throat or mouth.
  • Trouble swallowing.
  • Fever.
  • Vomiting.

Common adverse consequences of Aridol can be:

  • Trouble breathing, wheezing, or chest discomfort.
  • The throat; pain or irritation of the throat.
  • Runny nose.
  • Headache, dizziness.
  • Nausea, vomiting.

This isn't a complete list of all the side effects. Others could happen. Consult your physician for advice regarding medical adverse effects. You can report symptoms to the FDA at 1-800-FDA-1088.


Mannitol should not be used for inhalation if you've experienced allergies or asthma (wheezing, chest tightness, difficulty breathing) following the use of mannitol. Also, you shouldn't use this product if you're allergic to the capsule's components.

Before take this drug

It is not recommended to use this medication if you've suffered allergies or asthma (wheezing, chest tightness, difficulty breathing) following the use of mannitol. Also, you should not take this medication if you're allergic to the substances that make the capsules (such as shellac, gelatin, isopropyl alcohol, propylene glycol solution, titanium dioxide, and ferrous oxides).

You shouldn't be treated with Aridol. If you suffer from:

  • Aneurysms.
  • Untreated or uncontrolled high blood pressure that is not treated or controlled Untreated or uncontrolled high blood pressure.
  • A new cardiac stroke (or stroke).

Inform your doctor if you were ever diagnosed with:

  • A severe cough, or a bloody cough; mucus.
  • A punctured or collapsed lung.
  • Angina (chest pain).
  • Operation for your stomach, chest, or even your eyes.
  • If you've had the misfortune of coughing up blood.
  • If you're experiencing symptoms of an illness that could cause lung damage (such as a stuffy nose, sore throat, colds, fever, chest pain, or difficulty breathing).

Inform your doctor if you are nursing or pregnant.

How to take Mannitol?

Aridol is administered only in medical settings as part of the testing process to determine if you suffer from asthma or any other respiratory conditions. You'll be treated quickly when the test results in significant breathing problems.

You will be given your first dose of bronchitol (a testing dose for tolerance) in a clinical setting. The doctor will observe your breathing to ensure that the inhalation of mannitol is safe for you to take. Follow all instructions on the label of your prescription and also read the medication guides or instruction sheets. Follow the medication precisely as directed. Take note of and follow the instructions that are included in your medication. Talk to your pharmacist or doctor if you don't understand the instructions. The typical routine for bronchitol is a single dose at the beginning of each day and two doses about 2 to 3 hours prior to bedtime.

Your doctor may prescribe an additional inhaled medication that you must apply five to fifteen minutes prior to every dosage of bronchitol. Avoid using any other medications that are not prescribed by your physician. Do not ingest an inhalation capsule containing mannitol. It is intended for use with the inhaler device that comes with this medication. Each bronchitol inhaler device is to be used for a minimum of seven days. It is recommended to replace it every week with a brand new inhaler. Don't alter the dose or stop taking bronchitol unless on the advice of your physician. Storage at room temperature, far from humidity and extreme heat. Don't freeze or refrigerate. Get rid of any Bronchitol capsules that have been stored at temperatures greater than 85 degrees F (30 to 30 C). Dispose of the bronchitol inhaler after 7 days of usage.

Details on dosage

Usual Adult Dose for Oliguria:

Test dose for renal function prior to starting the treatment: 0.2 grams/kg of IV for 3 to 5 minutes, which results in a flow of urine that is between 30 and 50 milliliters per hour. A second test dose can be taken if the amount of urine doesn't increase. If there is no response after the second test dosage, the patient must be examined again.
Treatment: 300–400 mg/kg (21–28 grams for a 70kg patient) and up to 100 grams of 15–20 or 20% solutions once. The treatment is not recommended for patients suffering from persistent oliguria.
Prevention (for use in cardiovascular surgery and other types of surgeries) 50 to 100 grams IV. Typically, a 5–10, 20–or even 20% solution will be employed in accordance with the fluid requirements of the person.

Usual Adult Dose for Cerebral Edema:

0.25 to 2 g/kg in a 15% to 20% IV solution for at least 30 min, and administered not more often than once every 6–8 hours.
To achieve a substantial decrease in the intracranial pressure, the osmotic gradient of the cerebrospinal fluid and blood should be maintained at 20 mOsmol.
In patients with a weak or small body, 500 mg/kg could be enough.

What happens if I miss a dose?

Contact your doctor for advice when you have missed the dose.

What happens if I overdose?

For medical emergencies, seek emergency medical attention or contact the Poison Help line at 1-800-222-1222. Overdose symptoms can include wheezing, coughing, or extreme breathlessness.

What should be avoided?

Follow the instructions of your physician regarding food, drinks, or any activity.

Interaction with other drugs

Other drugs can impact the inhalation of mannitol, including prescription and over-the-counter medicines, vitamins, and herbal products. Discuss with your physician your current medications and any medications you begin or stop taking.