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Generic name: prabotulinumtoxinA [pra-BOT-ue-LYE-num-TOX-in-AY]
Drug class: skeletal muscle relaxants

What is Jeuveau?

Jeuveau comes from bacteria that cause botulism. Botulinum toxins block nerve activity in muscles. The prescription drug Jeuveau can temporarily reduce the appearance of wrinkles on the face (between the eyebrows). Jeuveau may be safe and effective for children, but it is not yet known.


Jeuveau contains botulinum toxins that can spread beyond the injection site. This can have serious and life-threatening effects.

If you experience hoarseness, drooping eyes, severe eye irritations, severe muscle weakness, or loss of bladder control or have trouble talking, breathing, or swallowing, call your doctor immediately.

Before you take this drug

Jeuveau should not be used if you have an allergy to prabotulinumtoxinA or if any of the following applies:

  • You have an infection where the injection will take place.
  • You have had an allergic reaction before to any product containing botulinum toxins, such as Botox or Dysport. Myobloc or Xeomin

Tell your doctor about any of the following to ensure that Jeuveau will be safe for you:

  • Other botulinum toxin injectables, such as Dysport and Myobloc, especially in the past 4 months;
  • Amyotrophic lateral sclerosis, also known as Lou Gehrig's disease (ALS),
  • myasthenia gravis;
  • Lambert-Eaton syndrome;
  • A side effect of prior botulinum toxin use
  • A breathing disorder, such as asthma or emphysema.
  • Problems with swallowing
  • Facial muscle weakness (droopy lids, weak forehead, and difficulty raising the eyebrows);
  • Bleeding problems
  • Heart disease
  • Surgery (especially on the face)

Jeuveau, which is made of donated plasma from humans, may contain viruses and other infectious agents. Plasma is treated and tested to reduce the chance of contamination. However, there is still some risk. You should ask your doctor if there are any risks.

Similar/related drugs

onabotulinumtoxinA, Botox Cosmetic, Daxxify, daxibotulinumtoxinA, and prabotulinumtoxinA

How to take Jeuveau?

Jeuveau is only to be administered by a medical professional. This includes when it's used cosmetically. A healthcare provider injects this medicine into a muscle. The injections of Jeuveau should be separated by at least three months.

The effects of the Jeuveau are only temporary. You may experience a complete recurrence of your symptoms within three months. Your symptoms may return sooner after repeated injections. This is especially true if you develop antibodies against the toxin. Don't seek Jeuveau from more than one doctor at the same time. Tell your new healthcare provider when you last received a botulinum injection.

This medication will not be more effective if you take it more than the prescribed amount. It may also cause serious side effects.

Details on dosage

Usual Adult Dose for Glabellar Lines:

Divided into five equal IM injections, each of four units:
Two injections into each corrugator (one in the inferior middle and one in the superior middle)+
One injection into the procerus muscle

The retreatment should not be administered more than three times a year.

If other botulinum products are being used or have been used, the cumulative dose should be taken into consideration.

Use: To temporarily improve the appearance of moderate or severe glabellar creases associated with corrugator muscle activity and/or procerus muscle.

What happens if I miss the dose?

Missing a dose of botulinum is unlikely to cause harm, as the toxin is only temporary and given at widely separated intervals.

What happens if I overdose?

Call 1-800-222-1222 for Poison Help or seek immediate medical attention.

Although symptoms of an overdose may not be apparent immediately, they can include muscle weakness and difficulty swallowing.

What should be avoided?

This medicine can cause dizziness, muscle weakness, or vision problems. These side effects may occur hours or even weeks after receiving a Jeuveau shot.

Do not drive or engage in hazardous activities until you have determined how the medicine will affect you.

Side effects of Jeuveau

If you experience any of the following symptoms of an allergic reaction: itching, hives, difficulty breathing, feeling as if you may pass out, swelling on your face, lips, or tongue, or a feeling of being about to faint, seek emergency medical attention.

Jeuveau contains botulinum toxins that can spread beyond the injection site. Some people have suffered life-threatening complications after receiving botulinum injections.

If you experience any of the following side effects, call your doctor immediately (up to a few hours or a few weeks after an injection).

  • Unusual or severe weakness of the muscles (especially if it occurs in an area not injected with medication);
  • Trouble breathing, speaking, or swallowing
  • Loss of bladder control
  • Hoarseness and drooping of the eyelids
  • Vision changes, eye pain or irritation, or increased sensitivity to light (your eyes could also be dry or irritated).
  • Chest pain or pressure, spreading pain to the jaw or shoulder, or irregular heartbeats

Common jeuveau side effects may include:

  • Headache;
  • Eyelids that droop
  • Increased white blood cell count;
  • Cold symptoms like a stuffy nose and sneezing.

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.

Interaction with other drug

Other drugs, such as vitamins and herbal products, may interact with prabotulinumtoxinA. Inform your doctor of all the medicines you are taking and those that you stop or start using.




Prescription only

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