What is Integrilin?
Integrilin prevents platelets from sticking together in your blood and forming blood clots. Certain heart and blood vessel conditions can cause an unwanted blood clot.
Integrilin can be used to treat severe chest pain, heart attacks, and other conditions. It is also given to people who have undergone a procedure known as angioplasty. This medication guide does not list all possible uses for Integrilin.
Warnings
If you are taking similar drugs, such as Abciximab or Tirofiban, then Integrilin is not recommended. If you've had a stroke, any type of bleeding, or had surgery within the last 6 weeks, you shouldn't receive Integrilin. Inform your doctor of any pregnancy or plans to become pregnant while taking Integrilin with aspirin.
Integrilin can make bleeding easier, even if the injury is minor, because it prevents your blood from coagulating. If you experience bleeding that won't stop, contact your doctor or get emergency medical help.
Before you take this drug
Integrilin should not be used if:
- Dialysis for kidney failure;
- Uncontrolled or severe high blood pressure;
- A disorder of bleeding or blood clotting, such as hemophilia and thrombocytopenia.
- If you've had a stroke or bleed of any kind in the last 30 days,
- If you've had surgery, an injury, or a medical emergency in the last 6 weeks,
- If you are currently receiving or soon will be receiving treatment with similar medications, such as abciximab or tirofiban,
Inform your doctor immediately of any potential kidney issues you are experiencing.
Integrilin should not be harmful to a baby in utero. Aspirin may be given along with Integrilin. Aspirin can cause bleeding if taken in the last three months of pregnancy. Aspirin may also have side effects on a newborn. It is unknown if eptifibatide can pass into breast milk or if it will harm a baby who is nursing. You should tell your doctor if you're breastfeeding a child.
How to take Integrilin?
Integrilin can be injected through an IV into a vein. This medicine will be administered by a healthcare provider. Integrilin can be given continuously for up to four days. The medicine is given for the duration of the angioplasty and up to 24 hours after. Sometimes, insulin and aspirin are given together. Aspirin dosage and duration should be according to your doctor's advice.
Your blood must be tested frequently to ensure that the medicine is working and not having any harmful effects. Integrilin can make you bleed more easily, even if the injury is minor. If you experience bleeding that won't stop, contact your doctor immediately or go to an emergency room.
Adult dose for myocardial infarction:
Initial: Administer 180 mcg/kg intravenous as soon as possible after diagnosis.
Maintenance: continuous infusion of 2 mcg/kg/min (following initial bolus) until hospital discharge or the initiation of CABG surgery. This can last up to 72 hours. Infusions should continue until the patient leaves the hospital or up to 18–24 hours after the PCI procedure.
Integrilin should not be administered to patients undergoing coronary bypass surgery.
Adult dose for Angina Pectoris:
Initial: Administer 180 mcg/kg intravenous as soon as possible after diagnosis.
Maintenance: continuous infusion of 2 mcg/kg/min (following initial bolus) until hospital discharge or the initiation of CABG surgery. This can last up to 72 hours. Infusions should continue until the patient leaves the hospital or up to 24 hours following the PCI, whichever is first. This allows for 96 hours.
Integrilin should not be administered to patients undergoing coronary bypass surgery.
Adult dose for acute coronary syndrome:
Initial: Administer 180 mcg/kg intravenous as soon as possible after diagnosis.
Maintenance: continuous infusion of 2 mcg/kg/min (following initial bolus) until hospital discharge or the initiation of CABG surgery. This can last up to 72 hours. Infusions should continue until the patient leaves the hospital or up to 18–24 hours after the PCI procedure.
Integrilin should not be administered to patients undergoing coronary bypass surgery.
Adult dose for percutaneous coronary intervention:
Initial: 180 mg/kg intravenous infusion administered just before PCI, followed by 2 mg/kg/min continuous infusion, and a second 18 mg/kg bolus given 10 minutes after the first bolus. The infusion should continue until discharge from the hospital, or up to 18–24 hours. The manufacturer suggests infusing for at least 12 hours.. Alternatively, an infusion duration of 16 hours is recommended by the ESPRIT study.
Integrilin should not be administered to patients undergoing coronary bypass surgery.
What happens if I miss the dose?
Integrilin will be administered by a medical professional, so you won't miss a dosage.
What happens if I overdose?
Call 1-800-222-1222 for poison help or seek immediate medical attention.
What should be avoided?
Avoid any activities that could increase your risk of injury or bleeding. Take extra precautions to avoid bleeding when shaving or brushing your teeth.
Before taking a nonsteroidal inflammatory drug (NSAID), consult your doctor. Aspirin, ibuprofen, naproxen, and other nsaids are included. Using an NSAID along with Integrilin can cause you to bleed or bruise easily.
Side effects of Integrilin
If you experience any of the following symptoms of an allergic reaction: hives, difficulty breathing, swelling of the face, lips, or throat, or difficulty breathing, seek emergency medical attention.
If you:
- Feelings of fainting.
- Any bleeding that won't stop
- If you have a bleeding problem around an IV, catheter, or any other place on your body where a needle has punctured your skin,
- Red or pink urine
- Signs of stomach bleeding include bloody or tarry stool, bloody vomit, or bloody coughing.
In older adults, the risk of bleeding is higher.
Integrilin may cause side effects such as:
- Blood;
- Feeling lightheaded
There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.
Interaction with other drug
Tell your doctor if you are taking any new medications or if you will stop using any of your current ones.
- Nonsteroidal anti-inflammatory drugs aspirin, ibuprofen, naproxen, diclofenac, and Indomethacin
- A blood thinner: warfarin (Coumadin), Jantoven,
- Any other medicine to treat or prevent clots: Plavix, Pradaxa, Xarelto, Ticlid, and others
This list is incomplete. Other drugs, such as prescription and OTC medicines, vitamins, and herbal products, may interact with eptifibatide. This medication guide does not list all possible interactions.
