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What is Inqovi?
Inqovi is a combination of cedazuridine and decitabine.Inqovi, a prescription medication, is used for treating adults with myelodysplastic disorders (MDS), including chronic myelomonocytic lymphoma (CMML). Myelodysplastic syndromes are blood or bone-marrow disorders.Inqovi may be safe and effective for children, but this is unknown.
Warnings
Inqovi can affect your immune system. Infections may be fatal or even more severe. Inqovi should not be given to anyone else, even if you are experiencing the same symptoms. It could harm them.
Before you take this drug
Tell your doctor about any of the following to ensure that Inqovi will be safe for you:
- Kidney disease
- Liver disease
Before starting the treatment, you may need a negative pregnancy result.Cedazuridine or decitabine may harm an unborn child or cause birth defects if either the mother or father uses this medicine.
- Do not take Inqovi while pregnant if you're a woman. Use birth control to avoid pregnancy during the time you use this medication and for 6 months following your last dose.
- Use effective birth control if you're a man and your partner can get pregnant. Continue to use birth control at least three months after your last dose.
- Do not hesitate to tell your doctor if you become pregnant while using this medication.
Inqovi can affect male fertility (the ability to have a child). It is still important to use birth control to avoid pregnancy, as the drug can harm an unborn child.
While using Inqovi, you should not breastfeed for 2 weeks following your last dose.Inqovi cannot be used by anyone under the age of 18.
How to take Inqovi?
Follow the directions on your prescription label and read all medication guides or instructions sheets. Read all the instructions and directions that come with your prescription. Sometimes your doctor will change the dose.Inqovi can be given as a 28-day cycle. The medicine may only be needed for the first five days of a cycle. Your doctor will decide how long you should take this medication.Inqovi should be taken on an empty stomach at least two hours before or after eating. Take Inqovi every day at the same time.Do not chew or crush the tablet.
You should not stop taking medication or change the dose without consulting your doctor.Other medications may be prescribed to prevent vomiting or nausea. Continue taking the prescribed medication. Do not take a second dose if you vomit soon after taking Inqovi. Do not take another dose of Inqovi until you have taken your next scheduled dosage.
Inqovi can affect your immune system. You could get more infections, including serious or deadly infections. You will need to be examined by your doctor on a regular schedule.In Zovi should be stored at room temperature, away from heat and moisture. Each tablet should be kept in its blister pack until the time comes to take it.
Details on dosage
Adult dose for myelodysplastic syndrome:
One tablet (containing 100 mg of cedazuridine and 35 mg of decitabine) orally on Days 1–5 of every 28-day cycle Continue for at least 4 cycles or until the disease progresses or toxicities are unacceptable.
Comments:
Consider administering antiemetics before each dose in order to minimize vomiting and nausea.
Use: For myelodysplastic syndromes (MDS), including previously treated and untreated de novo and secondary MDS with the following French-American-British subtypes (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, and chronic myelomonocytic leukemia [CMML]) and intermediate-1, intermediate-2, and high-risk International Prognostic Scoring System groups
What happens if I miss the dose?
If you miss a dose, take it as soon as possible. However, if the missed dose is more than 12 hours late, skip the missed dosage. Take only one dose at a time.
Continue to take all the daily doses of the treatment cycle, even if it means adding an extra day.
What happens if I overdose?
Call 1-800-222-1222 for poison help or seek immediate medical attention.
What should be avoided?
Eat nothing for at least two hours before or following the administration of this medication.
Side effects of Inqovi
If you experience any of the following: hives, difficulty breathing, swelling of the face, lips, or throat, and/or hives, seek emergency medical attention.
If you experience:
- Easy bruising, unusual bleeding, or purple or red patches under the skin
- Anemia (low red blood cells): pale skin; unusual fatigue; feeling lightheaded or short of breath;, cold hands and/or feet
- Low counts of white blood cells: fever, sores on the lips, tongue, or skin; sores in the throat; coughing, difficulty breathing,
- The symptoms of a lung disease include fever, chills, and a cough that produces mucus. Other signs are chest pain, shortness of breath, chest discomfort, and chest pain.
If you experience certain side effects, your treatment may be discontinued or delayed.
Inqovi may cause side effects such as:
- Fever and low blood cell count
- The bruised or bleeding area;
- Abnormal liver function tests
- Feeling tired, feeling dizzy, headache, feeling tired, feeling dizzy,
- You may experience swelling in your arms or legs.
- Muscle or joint pain
- Painful mouth sores;
- Shortness of breath is a lung infection.
- Nausea, nausea, and loss of appetite
- Diarrhea, constipation;
- Rash;
- Cold symptoms include stuffy noses, sneezing, coughs, and sore throats.
There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.
Interaction with other drug
Cedazuridine or decitabine may interact with other drugs, such as prescription and over-the-counter medicines, vitamins, and herbal products. Inform your doctor of all the medicines you are taking and those that you stop or start using.