What is Inotersen?
Inotersen can be used to treat polyneuropathy in adults who have hattr. Inotersen helps reduce symptoms like pain, numbness, and tingling. It can also help with diarrhea or constipation.
Inotersen can only be purchased from a pharmacy that is certified under a special programme.This medication guide does not list all possible uses of Inotersen.
Side effects of Inotersen
Seek immediate medical attention if you experience any of these symptoms: difficulty breathing, swelling in your face, lips, tongue or throat.
Inotersen may cause serious side effects. If you experience:
- Slurred speech, drooping eyes, or problems with balance or vision
- Shortness of breath, puffy eyes, or swelling in the hands or feet
- Vomiting, weight loss;
- Muscle weakness;
- Easy bruising or unusual bleeding from your nose, gums, or a wound, or purple or red patches under your skin
- Heavy bleeding during menstruation
- Signs of internal bleeding include a severe headache or neck stiffness. Other signs are black or bloody stool, pink or brown urine, or vomiting blood or vomit, which looks like coffee ground.
- If you have liver problems, such as dark urine, abdominal pain, or jaundice (yellowing skin or eyes),
- A reaction that occurs within two hours of an injection: headache, chest pains, flu-like symptoms (warmth or chills), redness in the palms of the hands, muscle pain, or uncontrolled movements
Inotersen can cause a variety of side effects.
- Bleeding or bruises
- Nausea;
- Fever;
- Tiredness;
- Headache
- Pain or redness at the injection site.
There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.
Warnings
Inotersen makes it easier to bleed, even from minor injuries. If the bleeding does not stop, seek medical attention.You can also experience bleeding inside your body.
Before you take this drug
Inotersen should not be used if:
- Low levels of platelets (your doctor will test for this);
- Inotersen can cause kidney problems.
Tell your doctor about any of the following:
- A liver transplant;
- A bleeding or blood clotting disorder;
- Kidney disease is a serious condition.
Inform your doctor if you are pregnant or nursing.You may find your name on a registry for pregnant women to track Inotersen's effects on the child.
How to take Inotersen?
Read all instructions or guides that come with your medication and follow all directions. Follow the directions on the label.Inotersen should be injected once a week under the skin. Your healthcare provider will tell you where to inject the inotersen. Each time you inject, use a new place. Don't inject in the same spot twice.Please read and follow all instructions for use that come with your medication. If you do not understand the instructions, ask your doctor or pharmacist for help.
Prepare an injection only when you are ready to administer it. If the color of your medicine has changed or if it contains particles, do not use it. For new medication, call your pharmacist.This medicine should be taken on the same day every week.You may be advised by your doctor to take a vitamin A supplement. Only take the prescribed amount of vitamin A. Overdosing on vitamin A may cause serious side effects, such as vision problems.
If you are pregnant, it is important to avoid taking excessive amounts of vitamin A.If you experience vision problems, especially at night (while taking vitamin A), call your doctor immediately.Inotersen makes it easier to bleed, even with minor injuries. If the bleeding does not stop, seek medical attention. You may experience bleeding inside your body. This could be in your stomach, intestines, or brain.
You will be required to undergo frequent medical tests. The results may delay your weekly injections. After stopping this medication, you may need to undergo medical tests.Store it in the fridge. Store it in the refrigerator. Keep the prefilled syringes in their cartons until you are ready to inject.Before injecting the dose, remove a syringe from the refrigerator. Let it come to room temperature for at least 30 minutes. Warm the syringe using hot water, sunlight, or a microwave.
Each prefilled syringe is only for one-time use. After one use, throw it out, even if the medicine is still inside.Only use a needle or syringe once, and then store them in a "sharps container" that is puncture-proof. Be sure to follow local or state laws on how to properly dispose of the container. Keep the container out of reach of pets and children.
Details on dosage
Usual Adult Dose for Amyloidogenic Transthyretin Amyloidosis:
Subcutaneous administration of 284 mg once a week
Comments:
If a missed dose occurs within two days of the next scheduled dosage, it should be given as soon as possible.
Use: For the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults.
What happens if I miss the dose?
If you have less than two days until your next dose, skip the missed one. Use only one injection at a time.
What happens if I overdose?
Call 1-800-222-1222 for poison help or seek immediate medical attention.
What should be avoided?
Inotersen should not be injected into skin that has been injured or is irritated. Avoid injecting into areas of skin with tattoos or scars.
Interaction with other drug
Inotersen may harm your kidneys if you are also taking certain medications for cancer, infection, osteoporosis, or organ rejection. Other drugs that can cause kidney damage include Advil, Motrin, and Aleve.
Tell your doctor if you are taking any other medications, including:
- A blood thinner: warfarin Coumadin Jantoven
- Medicines used to prevent blood clots include adenosine (adenosine), clopidogrel (clopidogrel), prasugrel (prasugrel), ticagrelor (ticagrelor), ticlopidine, and others.
This list is incomplete. Inotersen may be affected by other drugs, such as vitamins and herbs. This list does not include all possible drug interactions.
