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Generic name: sumatriptan (oral/nasal) [soo-ma-TRIP-tan]
Drug class: antimigraine agents

What is Imitrex?

Imitrex is a migraine medication that narrows the blood vessels surrounding the brain. Sumatriptan reduces substances that cause headache pain, nausea, and sensitivity to sound and light.Imitrex comes in oral tablets, nasal sprays, and injections. It is used to treat adult migraine headaches. Imitrex is only used to treat headaches. Imitrex will not reduce headaches or prevent them.

Imitrex is not recommended for treating a common headache or a headache causing loss of motion on one side. This medicine should only be used if your doctor has confirmed that you have migraine headaches.


Imitrex should not be used if you suffer from uncontrolled hypertension, heart disease, certain heart rhythm disorders, or a history of stroke. You also shouldn't use it if your circulation is affected by problems that lead to a lack of blood supply.If you've taken an MAO-inhibitor in the last 14 days (such as isocarboxazid or linezolid), phenelzine rasagiline, selegiline, or tranylcypromine, do not take this medication.

Tell your doctor if any of the following antidepressants are being taken: citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine (Prozac), Sarafem (Lexapro), fluvoxamine (Luvox), paroxetine (Paxil), sertraline (Zoloft), venlafaxine, or venlafaxine.

Imitrex can only be used to treat headaches that have already started. The drug will not reduce headaches or prevent them.Use Imitrex at least 24 hours after taking any other migraine headache medication.

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Before you take this drug

Imitrex should not be used if:

  • Heart problems or strokes (including "ministrokes")
  • Coronary heart disease; angina; blood circulation problems; and lack of blood supply to your heart.
  • Circulation problems affecting your legs, arms, stomach, intestines, or kidneys;
  • A heart disorder called Wolff-Parkinson-White syndrome;
  • Uncontrolled high blood pressure
  • Severe liver disease
  • A headache that is different from the usual migraine headaches.

Imitrex should not be used if MAO inhibitors have been taken in the last 14 days. It is possible that a dangerous drug interaction will occur. MAO inhibitors are isocarboxazid (linezolid), methylene blue injection, phenelzine, and other drugs.

Make sure to tell your doctor if you are taking stimulant medicines, opioids, herbal products, or medications for mental illness, Parkinson’s disease, serious infection, or nausea and vomiting prevention. These medications may interact with sumatriptan, causing a serious condition known as serotonin-induced syndrome.

Tell your doctor about any of the following to ensure that Imitrex will be safe for you:

  • Liver or kidney disease
  • Epilepsy
  • High blood pressure is a sign of a heart rhythm problem.
  • Risk factors for coronary heart disease include diabetes, menopause, and smoking.Being overweight, having high blood pressure, High cholesterol and having a history of coronary disease in the family.

This medicine is not known to harm an unborn child. Inform your doctor if you are pregnant or planning to become pregnant.

Sumatriptan may pass through breast milk. Do not breastfeed for 12 hours following the use of Imitrex. Throw away any milk collected if you are using a breast pump. Do not give it to your child.Imitrex should not be used by anyone under the age of 18.

How to take Imitrex?

Imitrex should be taken as soon as headache symptoms appear. Read all the instructions and directions that come with your prescription. Follow the directions on the label.Your first dose may be administered in a hospital setting or clinic to treat any serious side effects.You should read all the instructions that are included with your medicine. If you don't understand the instructions, ask your doctor or pharmacist.

Imitrex tablets should be taken whole, with a glass of water. Do not break the tablet.After taking Imitrex, if your headache doesn't go away completely, or if your headache goes away and then comes back again, take a second dose at least two hours after your first.Do not exceed the recommended dosage. The overuse of migraine headache medication can worsen headaches. If the medication seems to be less effective in treating migraine attacks, tell your doctor.

Take no more than 200 mg of Imitrex orally in a 24-hour period.Use no more than 40 mg of Imitrex in a 24-hour period.If your symptoms don't improve or you experience more than four headaches within a month (30 days), call your doctor.Store away from moisture, light, heat, and heat at room temperature. Store away from moisture, heat, and light. Do not freeze.

Details on dosage

Adult dose for migraine:

Only use after a migraine diagnosis has been made.
Initial dose: oral, 25 mg, 50mg, or 100mg
If there is a response to the first dose, a second dosage can be given at least two hours after the first dose.
Oral doses between 50 and 100mg may be more effective than 25mg; however, 100mg may not have a greater effect than 50 mg.
Maximum dose: 200 mg per 24 hours.
Nasal spray initial dose: 5 mg or 10 mg in one nostril.
Apply the 20 mg and 5 mg doses in a single nostril spray; the 10mg dose can be administered by 5mg into each nostril.
If there is a response to the first dose, a second dosage can be given at least two hours after the first dose.
Maximum dose: 40 mg per 24 hours.
This drug should not be used as a migraine preventative.
Higher doses can have a greater impact, but they also come with a higher risk of side effects.
The safety of treating more than four headaches on average in a 30-day period has not yet been proven.
Use: To treat acute migraines with or without an aura.

What happens if you miss a dose of the medication?

Imitrex does not require a schedule of daily doses because it is only used as needed. If your symptoms don't improve after taking this medication, call your doctor.

What happens if you overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

Overdose symptoms include tremors and skin redness on your arms or legs. They may also include weakness, lack of coordination, breathing difficulties, blue lips or fingernails, or vision problems.

What should I avoid when using Imitrex?

Do not use Imitrex for migraine headaches within 24 hours of using any other migraine headache medication.

  • Sumatriptan injection, almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, zolmitriptan,
  • Ergot medicine such as dihydroergotamine, ergotamine, ergonovine, or methylergonovine.

Do not drive or engage in hazardous activities until you have determined how the medicine will affect you. You may be unable to react properly.

Imitrex side effect

If you experience any of the following symptoms of an Imitrex allergy: itching, difficulty breathing, swelling of the face, lips, or tongue, or difficulty breathing, seek emergency medical attention.

If you experience any of the following symptoms, stop using Imitrex immediately and contact your doctor.

  • Diarrhea and sudden severe abdominal pain
  • Shortness of breath and irregular heartbeats are symptoms of severe chest pain.
  • A seizure (convulsions);
  • A severe headache can cause blurred vision or a pounding sensation in the neck, ears, or head.
  • Problems with blood circulation in the legs or feet: cramps or tightness, numbness, tingling or numbness, muscle weakness, pain or burning, feeling of coldness, changes in color (pale blue or pale), hip pain
  • Heart attack symptoms: pain in the chest or pressure on your chest, pain that spreads to your shoulder or jaw, nausea, and sweating.
  • High levels of serotonin cause agitation and hallucinations; fever; sweating or shivering; a fast heartbeat; and muscle stiffness. Twitching. Loss of coordination.
  • Signs of a Stroke: sudden numbness, weakness, or headache (especially on one side), slurred or distorted speech, or problems with vision, balance, or coordination.

Imitrex may cause side effects such as:

  • You may feel a tightness in your chest or throat.
  • Pressure or a heavy feeling anywhere in your body
  • Feeling hot or cold; numbness and tingling;
  • Dizziness, drowsiness, weakness;
  • After using nasal medication, you may experience an unpleasant taste in the mouth.
  • After using nasal medication, you may experience pain, burning, numbness, or tingling.
  • After using nasal medication, you may experience a runny or swollen nose.

There may be other side effects. For medical advice on side effects, call your doctor. The FDA can be contacted at 1-800-FDA-1088 to report side effects.

Interaction with other drug

Imitrex can cause high serotonin levels to build up in the body. This condition is called "serotonin syndrome" and can be fatal. Tell your doctor if:

  • Medicine to treat depressive disorder;
  • Medicine for Parkinson’s disease
  • Medicine for serious infections
  • Herbal products
  • Stimulant medicines;
  • Opioid medicine;
  • Medicine to prevent nausea and vomiting

This list is incomplete. Sumatriptan may interact with other drugs, such as prescription and over-the-counter medicines, vitamins, and herbal products. This list does not include all drug interactions.



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