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Ibuprofen PM

Generic name: diphenhydramine and ibuprofen [DYE-fen-HYE-dra-mean-and-EYE-blue-proe-fen]
Brand names: Advil PM Advil Liqui-Gels Ibuprofen PM Motrin AM
Drug class: analgesic combinations

What is Ibuprofen PM?

Diphenhydramine acts as an antihistamine. Ibuprofen is a nonsteroidal analgesic drug (NSAID).

Ibuprofen PM is a combination medication used to treat occasional insomnia that may be associated with minor aches or pains. Ibuprofen is not recommended for treating insomnia with pain or frequent sleep problems.Ibuprofen PD is suitable for adults and children over 12 years of age.Ibuprofen PM can be used in other ways not mentioned in this guide.

Side effects of Ibuprofen PM

If you experience symptoms of an allergic reaction, such as hives, difficulty breathing, swelling on your face or in your throat, or a severe reaction to the skin (fever or sore throat with burning eyes, severe skin pain or blistering, or a red or purple rash), seek emergency medical attention.

Immediately seek emergency medical assistance if any of the symptoms above appear.

This medicine can cause serious side effects. If you experience:

  • Any skin rash;
  • A feeling of lightheadedness, as if you could pass out.
  • Signs of stomach bleeding include bloody or tarry stool, vomiting that looks like coffee, or coughing up blood.
  • Kidney problems: little or no urinating; painful or difficult urination; swelling of the feet or ankles; feeling tired or short of breath.
  • Liver problems: nausea; itching; fatigue; flu-like symptoms; and loss of appetite. Dark urine and clay-coloured stools. Jaundice.

Ibuprofen PM can cause the following side effects:

  • Drowsiness;
  • Day-time drowsiness, dizziness, "hangover" feeling;
  • Upset stomach heartburn diarrhea constipation
  • Dry mouth, nose, or throat
  • Blurred vision
  • Itching or a rash that is mild
  • Ringing in the ears

There may be other side effects.For medical advice regarding side effects, call your physician. To report these events to the FDA directly, call their 1-800FDA-1088 number.


Ibuprofen may increase the risk of a fatal stroke or heart attack. Ibuprofen PM should not be taken before or after heart bypass surgeries.Ibuprofen may cause serious stomach or intestinal bleeding that could prove fatal.

This medicine should be taken exactly as prescribed. Too much diphenhydramine may cause heart problems, seizures, or even death.

Before you take this drug

Ibuprofen may increase your risk of a fatal heart attack or stroke even if there are no risk factors. This medicine should not be taken before or immediately after heart bypass surgery.Ibuprofen can also cause fatal stomach or intestinal bleeding. Ibuprofen PM can cause these conditions without warning, especially for older adults.

This medicine should not be used if you're allergic to diphenhydramine, ibuprofen, or have had an aspirin attack.If you have had any of the following:

  • High blood pressure, heart disease
  • A heart attack, stroke, or blood clot
  • Stomach ulcers or bleeding
  • A breathing problem such as emphysema or chronic bronchitis.
  • Liver or kidney disease
  • Glaucoma;
  • An enlarged prostate, or problems with urination
  • If you are taking aspirin for heart attacks or stroke prevention,

If you plan to get pregnant or are currently pregnant, consult your doctor before taking this medication. Ibuprofen taken during the last twenty weeks of pregnancy can cause serious kidney problems for the unborn child.Consult your doctor before taking this medication if you're breastfeeding.

How to take Ibuprofen PM?

Follow the directions on the label or those prescribed by your physician. Use the lowest effective dose to treat your condition.Too much diphenhydramine may cause serious heart problems, seizures, or even death.

Ibuprofen should not be given to children younger than 12 years. Ask a doctor for advice before giving antihistamines to children. Misuse can lead to death in young children.If you have an upset stomach, take this medication with milk or food.Take this medication for no more than 10 days unless your doctor has prescribed it.If your symptoms do not improve or worsen, seek medical assistance immediately.

Tell your doctor or surgeon, if you've taken this medication within the last few days, if you are going to need medical testing or surgery.Store away from heat and moisture at room temperature.

What happens if I miss the dose?

You may not have a schedule for Ibuprofen PM, as it is only used when necessary. If it is almost time for your next dose, just skip it altogether and continue as scheduled. Never take two doses in one go.

What happens if I overdose?

Call 1-800-222-1222 for poison help or seek immediate medical attention.

What should be avoided?

Ibuprofen pm can affect your reactions. Avoid driving and other hazardous activities until you are familiar with how they will affect you. You may be unable to react properly.

Consult your doctor or pharmacist prior to using any other medications for pain, fever or swelling. These medicines may contain ibuprofen or diphenhydramine. Avoid using diphenhydramine as an anti-itch medication on your skin.Avoid alcohol. Alcohol can increase the risk of stomach bleeding.Aspirin should only be taken if your doctor recommends it.

Interaction with other drug

Before taking Ibuprofen PM, ask your doctor if you are on an antidepressant. Certain antidepressants may cause you to bruise or bleed easily.

Before using Ibuprofen PM in conjunction with other medications, ask your doctor or pharmacist.

  • A blood thinner (Warfarin Coumadin Jantoven);
  • A diuretic, or "water pill,"
  • Use of diphenhydramine on the skin (Benadryl)

This list is incomplete. Ibuprofen PM may interact with other drugs, such as vitamins and herbs. This list does not include all possible interactions with other drugs.