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Hylan G-F 20

Generic names: Synvisc and Synvisc One
Dosage form: intra-articular solution (16 mg/2 mL; 48 mg/6 mL)
Drug class: Viscosupplementation agents

What is Hylan G.F. 20?

Hylan G-20 is similar to fluid around your joints. This fluid is a lubricant for joints and a shock absorber.Hylan G-F-20 is used to treat knee osteoarthritis.Hylan G-F-20 is typically prescribed after other arthritis medications have failed to treat symptoms.Hylan G-F 20 can be used in other ways not mentioned in this guide.

Side effects of Hylan G-F 20 

Symptoms of an allergic reaction may include hives, difficulty breathing and swelling of lips, face, tongue or throat. Seek medical assistance immediately if this happens to you.If you experience severe pain or swelling in the area of the knee following the injection, call your doctor immediately.

Side effects of hylan G-F 20 include:

  • The injection site may be accompanied by pain, inflammation, or swelling.
  • Muscle pain; trouble walking
  • Fever, chills, nausea;
  • Feeling prickly on your skin
  • Headache, dizziness, or
  • Itching around the knee

There may be other side effects. For medical advice on side effects, call your doctor.Reaching out to the FDA can be done at 1-800-FDA-1088 if any adverse events arise, to report.

Similar/related drugs

Aspirin, prednisone, ibuprofen, duloxetine, naproxen, and Cymbalta

Warnings

If you have a skin infection on your knee or around your knee, then you should not be receiving hylan G-F 20.If you experience severe pain or swelling in the area of the knee following the injection, call your doctor immediately.

Before you take this drug

If you have an allergy to hylan G-F 20 or a skin infection around your knee, you should not use it.

Tell your doctor about any of the following to ensure that hylan G-F 20 will be safe for you:

  • Blood clots in the legs or problems with circulation
  • Allergy to Birds, Feathers, or Egg Products

There is no way to know if Hylan G-20 will harm an unborn child.Notify your doctor immediately if you are pregnant, planning on becoming pregnant, or hoping to conceive.There is no way to know if hylan G-20 passes into breast milk or if it can harm a baby who is nursing. Inform your doctor if a child is breastfed.Hylan G-F-20 is not recommended for anyone under the age of 21.

How to take Hylan F-20?

Hylan G-20 is injected into the knee joint. Healthcare providers will administer this injection.It is recommended that you receive three injections of the Synvisc Hylan F-20 brand. The synvisc-one hylan F-20 is only given once. The number of injections will be determined by your doctor.Your doctor may suggest that you rest your knee after the injection or apply ice to it for a few minutes.

Details on dosage

Adult dose for osteoarthritis:

21 years and older
Inject 16mg (2 mL) intra-articularly into the knee every week for three weeks.
Comments:
The aseptic technique must be strictly adhered to.
Remove synovial effusion or fluid using a needle of 18 to 22 gauge before each injection.
Use the same needle size (18- to 22-gauge) for both injecting the drug and removing the synovial fluid.
Use: To treat pain associated with osteoarthritis of the knee in patients who do not respond to nonpharmacologic treatment and simple anti-analgesics.

What happens if I miss the dose?

If you are unable to attend your appointment for a hylan G-20 injection, call your doctor.

What happens if I overdose?

Overdoses are unlikely because hylan GF-20 is administered by a health care professional in a medical environment.

What should be avoided?

Avoid jogging or strenuous activities for at least 48 hours after the injection. This includes high-impact sports like soccer or tennis. Avoid standing or doing any weight-bearing activities for more than an hour. You should ask your doctor for the recommended time before you can resume such activities.

Interaction with other drug

Other drugs, including vitamins and herbal products, may interact with hylan G-20. Inform your healthcare providers of all the medicines you are taking and those you plan to take.