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Humulin N

Generic name: insulin isophane [IN-soo-lin-EYE-soe-fane]
Brand names: Humulin, Nololin,
Drug class: insulin

What is Humulin N?

Humulin N, a synthetic form of the hormone produced by the body, is available in a variety of forms. Insulin works by lowering the levels of sugar (glucose) in the blood. Insulin isophane, an intermediate-acting form of insulin, starts working within 2 to 4 hours after injection. It peaks between 4 and 12 hours, then continues to work for 12 to 18 hours.Humulin N can be used to control blood sugar levels in children and adults with type 2 diabetes.Humulin N can be used in other ways not mentioned in this guide.


Humulin N should not be used if you have an episode of low blood sugar.Do not share an injection pen, syringe, or syringe, even if it has been changed.Humulin N can cause hypoglycemia, or low blood glucose. This may manifest as headaches, fatigue, or irritability. Other symptoms include pale skin, sweating, and irritability. Be on the lookout for symptoms of low blood glucose. If you suspect low blood sugar, carry a hard candy that is not dietetic or glucose tablets.

Side effects of Humulin N 

If you experience any of the following symptoms: swelling or redness where an injection has been given; itchy or dry skin; a rash all over your body; or chest tightness,

If you experience:

  • Fluid retention: weight gain, swelling of your hands and feet, feeling out of breath, or
  • Low sodium: leg cramps, constipation, increased thirst or urination, numbness, tingling, or muscle weakness.

Some of the common side effects that Humulin N may cause include:

  • Low blood sugar
  • Weight Gain and Swelling in Hands or Feet
  • Itching, mild skin reaction
  • The skin may become thicker or hollower where the medication was injected.

There may be other side effects. For medical advice on side effects, call your doctor. Contacting the FDA in regards to adverse side effects is easy - simply dial 1-800-FDA-1088!

Similar/related drugs

Ozempic, Mounjaro, Metformin, Trulicity, Lantus, Victoza, and Tresiba

Before you take this drug

Humulin N should not be used if you have an allergy to insulin isophane or if your blood sugar level has dropped due to hypoglycemia.Humulin N should only be given to children with a doctor’s prescription.

Tell your doctor about any of the following to ensure that Humulin N will be safe for you:

  • Liver or kidney disease
  • Low potassium levels in the blood (hypokalemia)

Inform your doctor if, in addition to pioglitazone and rosiglitazone, you are also taking glimepiride (or metformin). Certain oral diabetes medications can increase the risk of heart problems if you use insulin.Inform your doctor immediately if you are pregnant or nursing.If you're pregnant or planning to become pregnant, follow your doctor's advice about using Humulin N.

How to take Humulin N?

Read all instructions or guides that come with your medication and follow all directions. Follow the directions on the label.Humulin N can be injected into the skin. You can learn how to use the medicine properly yourself from a healthcare provider.Never give Humulin N to a patient who is using an insulin pump.Humulin N should not be used with an insulin pump or mixed with any other insulin. Never inject into a vein, muscle, or blood vessel.This medicine should not be injected into damaged skin that is bruised, pitted, thickened, or scaly.Please read and follow all directions that accompany your medication carefully. If any instructions do not make sense to you, do not take Humulin N. If any inquiries arise regarding its use or administration, reach out to your pharmacist or physician immediately.Humulin N will appear cloudy when mixed. If the mixture is clear or contains particles, do not use it. For new medicines, call your pharmacist.You will be shown by your healthcare provider where to inject humulin. Each time, use a new location.Do not inject at the same site twice.Use only the Humulin N-supplied injection pen. Attach a fresh needle each time. Don't transfer insulin from a pen to a syringe.

Do not share an injection pen, syringe, or other device with anyone else. This is true even if you have changed the needle. It can spread infections and diseases from person to person.All diabetics can experience low blood sugar. headache, and other symptoms include dizziness or nausea. Always keep sugary foods such as hard candy, crackers, or raisins on hand to treat low blood sugar.If you are suffering from severe hypoglycemia and can't eat or drink anything, your doctor may prescribe a glucagon injection kit. Make sure that your family members and friends are familiar with how to administer this emergency injection.Watch for signs of hyperglycemia (high blood sugar), such as increased thirst and urination.Stress can affect blood sugar levels. Other factors that may influence blood sugar include illness, surgery, or alcohol consumption. Consult your doctor before changing the dose or schedule of your medication.Humulin N may be part of a comprehensive treatment program, which could also include diet and exercise, weight management, blood glucose testing, and special medical care. Please follow your doctor's directions very carefully.This medicine should be kept in the original container, away from heat and sunlight. You should not transfer insulin from the vial to a syringe before you are ready for an injection. Store insulin away from the cooling element of a fridge. Do not use any frozen insulin.

Humulin N:

  • Use within the expiration date.
  • Keep your medication at room temperature, and use it within the specified number of days in the instructions for use that came with the medicine.

Storing Humulin N:

  • Keep your medication in the refrigerator or at room temperature as instructed in the instructions for use that came with it. Injectors that are still in use should not be refrigerated.
  • Humulin N in use is only stable for a limited number of days. Toss away any medicine that has not been used in this time frame. Keep your medicines in accordance with the instructions provided.

Only use a needle or syringe once, and then store them in a "sharps container" that is puncture-proof. Be sure to follow local or state laws on how to properly dispose of the container. Keep the container out of reach of pets and children.Wear or carry medical identification in case of an emergency to alert others that you have diabetes.

What happens if I miss the dose?

If you are almost due for your next dose, skip the missed dose. Never take two doses of the same medicine at once.Refill your Humulin N prescription before you run out.

What happens if I overdose?

Call the Poison Help Line at 1-800-222-1222 or seek emergency medical care. An insulin overdose can lead to life-threatening hypoglycemia. The symptoms include confusion, drowsiness or blurred vision, numbness in the mouth or tongue, difficulty speaking, muscle weakness, or jerky movements.

What should be avoided?

Insulin can cause low sugar levels. Do not drive or operate machinery until you have determined how the medication will affect you.Check the label of your medicine before you inject insulin to avoid medication mistakes. Some brands are interchangeable with others, such as insulin isophane or syringes.Avoid alcohol. Alcohol can cause low sugar levels and interfere with diabetes treatment.

Interaction with other drug

Humulin N might not work as effectively if you are taking other medications. It includes over-the-counter and prescription medicines, vitamins, and herbal products. You may also experience fewer hypoglycemia symptoms when taking certain drugs, making it more difficult to detect low blood sugar. This list does not include all possible interactions. Inform your doctor of all medications you begin or stop taking.